dihydro-3-(RS)-(2-methylpropyl)-2,5-furandione | 14035-83-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dihydro-3-(RS)-(2-methylpropyl)-2,5-furandione
• 英文别名: dihydro-3-(2-methylpropyl)-2,5-furandione；2(S)-isobutylsuccinic anhydride；3-isobutyl-succinic anhydride；isobutylsuccinic anhydride；3-isobutylsuccinic anhydride；3-(2-Methylpropyl)oxolane-2,5-dione
• CAS: 14035-83-7
• 化学式: C₈H₁₂O₃
• 分子量: 156.181
• InChiKey: RMYDZBMRAPLPAL-UHFFFAOYSA-N

物化性质

• 沸点：
  261.1±9.0 °C(Predicted)
• 密度：
  1.086±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  dihydro-3-(RS)-(2-methylpropyl)-2,5-furandione 在 盐酸 、 氢氧化钾 、 盐酸羟胺 、 三乙胺 、 N,N'-羰基二咪唑 作用下， 以 甲醇 、 乙醚 、 氯仿 为溶剂， 反应 218.0h， 生成 伊洛马司他
  参考文献：
  名称：

  Matrix Metalloproteinase Inhibitors:  A Structure−Activity Study

  摘要：

  Modifications around the dipeptide-mimetic core of a hydroxamic acid based matrix metalloproteinase inhibitor were studied. These variations incorporated a variety of natural, unnatural, and synthetic amino acids in addition to modifications of the P1' and P3' substituents. The results of this study indicate the following structural requirements: (1) Two key hydrogen bonds must be present between the enzyme and potent substrates. (2) Potent inhibitors must possess strong zinc-binding functionalities. (3) The potential importance of the hydrophobic group at position R3 as illustrated by its ability to impart greater relative potency against stromelysin when larger hydrophobic groups are used. (4) Requirements surrounding the nature of the amino acid appear to be more restrictive for stromelysin than for neutrophil collagenase, 72 kDa gelatinase, and 92 kDa gelatinase. These requirements may involve planar fused-ring aryl systems and possibly hydrogen-bonding capabilities.

  DOI：

  10.1021/jm970494j
• 作为产物：
  描述：

  异丁基琥珀酸 在 乙酸酐 作用下， 反应 1.0h， 生成 dihydro-3-(RS)-(2-methylpropyl)-2,5-furandione
  参考文献：
  名称：

  N-羟基琥珀酰亚胺衍生物对人白细胞弹性蛋白酶的抑制作用。结构－活动－关系研究。

  摘要：

  已经合成了一系列衍生自3-烷基-N-羟基琥珀酰亚胺的化合物，并且已经研究了它们对人白细胞弹性蛋白酶的抑制活性。已经发现在C-3位具有异丁基或异丙基的化合物是该酶特别有效的灭活剂。反式-苯乙烯基的引入（如化合物16和18中的）导致抑制活性的急剧增强，表明苯环和酶的S2'亚位点之间有利的相互作用。发现该化合物在缓冲溶液中高度稳定，在17小时（观察期）后结构完整性没有明显变化。对模型化合物和高场NMR的研究表明，这些化合物可作为酶的基于机理的抑制剂。

  DOI：

  10.1021/jm00127a034

文献信息

• Process for preparing synthetic matrix metalloprotease inhibitors
  申请人：Glycomed Incorporated

  公开号：US05892112A1

  公开（公告）日：1999-04-06

  Synthetic mammalian matrix metalloprotease inhibitors are disclosed that are useful for treating or preventing diseases wherein said diseases are caused by unwanted mammalian matrix metalloprotease activity and include skin disorders, keratoconus, restenosis, rheumatoid arthritis, wounds, cancer, angiogenesis and shock.

  揭示了一种合成的哺乳动物基质金属蛋白酶抑制剂，用于治疗或预防由不需要的哺乳动物基质金属蛋白酶活性引起的疾病，包括皮肤疾病、角膜圆锥症、再狭窄、类风湿关节炎、伤口、癌症、血管生成和休克。
• USE OF NITROGEN COMPOUNDS QUATERNISED WITH ALKYLENE OXIDE AND HYDROCARBYL-SUBSTITUTED POLYCARBOXYLIC ACID AS ADDITIVES IN FUELS AND LUBRICANTS
  申请人：BASF SE

  公开号：US20160130514A1

  公开（公告）日：2016-05-12

  The invention relates to the use of quaternized nitrogen compounds as a fuel and lubricant additive or kerosene additive, such as in particular as a detergent additive, for decreasing or preventing deposits in the injection systems of direct-injection diesel engines, in particular in common rail injection systems, for decreasing the fuel consumption of direct-injection diesel engines, in particular of diesel engines having common rail injection systems, and for minimizing the power loss in direct-injection diesel engines, in particular in diesel engines having common rail injection systems; the invention further relates to the use as an additive for petrol, in particular for operation of DISI engines.

  该发明涉及将季铵化氮化合物用作燃料和润滑剂添加剂或煤油添加剂，特别是作为清洁剂添加剂，用于减少或预防直喷柴油发动机的喷射系统中的沉积物，在特定是在共轨喷射系统中，用于降低直喷柴油发动机的燃料消耗，特别是具有共轨喷射系统的柴油发动机，并用于减少直喷柴油发动机的功率损失，特别是在具有共轨喷射系统的柴油发动机中；该发明还涉及将其用作汽油添加剂，特别是用于DISI发动机的运行。
• Nitroalkanes and Dimethyl Maleate as Source of 3-Alkyl Succinic Anhydrides and (E)-3-Alkylidene Succinic Anhydrides
  作者：Roberto Ballini、Giovanna Bosica、Dennis Fiorini、Paolo Righi

  DOI：10.1055/s-2002-23548

  日期：——

  Nitroalkanes react with dimethyl maleate giving a tandem Michael addition/elimination of nitrous acid. The obtained (E)-2-alkylidene dimethyl succinates are: (i) reduced to the corresponding 2-alkyl dimethyl succinates which after hydrolysis produce 1,4-dicarboxylic acids that are prone to convert into the corresponding 3-alkyl succinic anhydrides or (ii) hydrolysed to (E)-2-alkylidene-succinic acids that

  硝基烷烃与马来酸二甲酯反应产生亚硝酸的串联迈克尔加成/消除。获得的 (E)-2-亚烷基琥珀酸二甲酯是： (i) 还原为相应的琥珀酸 2-烷基二甲酯，水解后产生易于转化为相应的 3-烷基琥珀酸酐的 1,4-二羧酸或 ( ii)水解成(E)-2-亚烷基-琥珀酸，容易环化成(E)-3-亚烷基琥珀酸酐。
• Silsesquioxane derivative and process for producing the same
  申请人：Yoshida Kazuhiro

  公开号：US20060052623A1

  公开（公告）日：2006-03-09

  The PSQ silsesquioxane derivative of the invention is represented by Formula (1), and it may be utilized as additives to ordinary organic polymers for improving the flame retardancy, heat resistance, weather resistance, light resistance, electric insulating property, surface property, hardness, mechanical strength and chemical resistance thereof. In Formula (1), R is hydrogen, alkyl, aryl or arylalkyl; at least one Y is a group represented by Formula (2) and the other Y is hydrogen; in Formula (2), R 1 and R 2 are a group independently defined similarly to R; and Z is preferably a functional group, or a group having a functional group.

  该发明的PSQ硅氧烷衍生物由化学式（1）表示，可用作普通有机聚合物的添加剂，以改善其阻燃性、耐热性、耐候性、耐光性、电绝缘性、表面性能、硬度、机械强度和化学稳定性。在化学式（1）中，R为氢、烷基、芳基或芳基烷基；至少一个Y是由化学式（2）表示的基团，另一个Y为氢；在化学式（2）中，R1和R2是独立定义的与R类似的基团；Z最好是一个功能基团，或具有功能基团的基团。
• POLYSILOXANE COMPOUND AND METHOD OF PRODUCING THE SAME
  申请人：Ootake Nobumasa

  公开号：US20110178313A1

  公开（公告）日：2011-07-21

  A polysiloxane represented by the formula (1) or (2): where R, R 1 , R 2 , m and n are defined in the specification.

  由公式（1）或（2）表示的聚硅氧烷：其中R、R1、R2、m和n在规范中定义。