hexaethyleneglycol dimethacrylate | 26930-99-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: hexaethyleneglycol dimethacrylate
• 英文别名: 3,6,9,12,15-Pentaoxaheptadecane-1,17-diyl bis(2-methylacrylate)；2-[2-[2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate
• CAS: 26930-99-4
• 化学式: C₂₀H₃₄O₉
• 分子量: 418.485
• InChiKey: SNDXOIQRPOSFPB-UHFFFAOYSA-N

物化性质

• 沸点：
  483.9±40.0 °C(Predicted)
• 密度：
  1.080±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  29
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  98.8
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  六甘醇 、 甲基丙烯酰氯 在 四甲基丙二胺 作用下， 以 乙腈 为溶剂， 生成 hexaethyleneglycol dimethacrylate
  参考文献：
  名称：

  Improvement of solid material for affinity resins by application of long PEG spacers to capture the whole target complex of FK506

  摘要：

  Solid materials for affinity resins bearing long PEG spacers between a functional group used for immobilization of a bio-active compound and the solid surface were synthesized to capture not only small target proteins but also large and/or complex target proteins. Solid materials with PEG1000 or PEG2000 as spacers, which bear a benzenesulfonamide derivative, exhibited excellent selectivity between the specific binding protein carbonic anhydrase type II (CAII) and non-specific ones. These materials also exhibited efficacy in capturing a particular target at a maximal amount. Affinity resins using solid materials with PEG1000 or PEG2000 spacers, bear a FK506 derivative, successfully captured the whole target complex of specific binding proteins at the silver staining level, while all previously known affinity resins with solid materials failed to achieve this objective. These novel affinity resins captured other specific binding proteins such as dynamin and neurocalcin delta as well. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.05.014

文献信息

• [EN] (METH)ACRYLOXY-CONTAINING TRISILOXANE, SILOXANE-CONTAINING POLYMERS AND BIOMEDICAL DEVICES THEREFROM<br/>[FR] TRISILOXANE CONTENANT UN (MÉTH)ACRYLOXY, POLYMÈRES CONTENANT UN SILOXANE ET DISPOSITIFS BIOMÉDICAUX LES CONTENANT
  申请人：MOMENTIVE PERFORMANCE MAT INC

  公开号：WO2014123956A1

  公开（公告）日：2014-08-14

  There is provided a trisiloxane having a 3-(meth)acryloxy-substituted (hydroxylcyclohexyl)ethyl group, useful in making water absorbing silicone-hydrogel films for biomedical devices, such as contact lens, and a process for producing these monomers. This invention also provides for copolymers made from the trisiloxane having a 3-(meth)acryloxy-substituted (hydroxylcyclohexyl)ethyl group described herein.

  提供了一种三硅氧烷，其具有3-(甲基)丙烯氧基取代的(羟基环己基)乙基基团，可用于制备用于生物医疗器械（如隐形眼镜）的吸水硅烷凝胶膜，并提供了制备这些单体的方法。本发明还提供了由所述具有3-(甲基)丙烯氧基取代的(羟基环己基)乙基基团的三硅氧烷制成的共聚物。
• HYDROPHILIC SILICONE COMPOSITION
  申请人：Bhat Shreedhar

  公开号：US20150158889A1

  公开（公告）日：2015-06-11

  A composition comprising a carbocyclic group and a hydrophilic moiety attached thereto an alpha, beta-unsaturated organosilicon compound. Such compounds are useful in developing water absorbing silicone-hydrogel films. Silicone-hydrogel films provide increased oxygen to pass through a lens or other treated materials.

  一种组成物包括一个含碳环基和一个亲水基团附着在α，β-不饱和有机硅化合物上。这样的化合物在开发吸水硅水凝胶薄膜方面非常有用。硅水凝胶薄膜能够提供更多的氧气穿过镜片或其他处理材料。
• Tulobuterol adhesive patch
  申请人：Kawamura Naohisa

  公开号：US20070154535A1

  公开（公告）日：2007-07-05

  The present invention provides a tulobuterol adhesive patch comprising (a) a support, (b) an acrylic pressure-sensitive adhesive layer containing the percutaneously absorbing drug tulobuterol and if necessary a lipophilic oily plasticizer, and (c) a release liner, laminated in that order, wherein the acrylic pressure-sensitive adhesive is a copolymer obtained by copolymerizing an acrylic monomer which is acetoacetoxyalkyl (meth)acrylate with one or more other vinyl monomers, to yield a tulobuterol adhesive patch with excellent release and skin permeability of tulobuterol from the pressure-sensitive adhesive layer, low skin irritation and excellent safety.

  本发明提供一种土洛布特罗粘贴剂片，包括（a）支撑层，（b）含有经皮吸收药物土洛布特罗的丙烯酸压敏粘合剂层，如有必要，还包括一个亲脂性油性增塑剂，以及（c）释放衬底，按顺序层压，其中丙烯酸压敏粘合剂是通过共聚合一种丙烯酸单体即乙酰乙酰氧基烷基（甲）丙烯酸酯与一个或多个其他乙烯单体得到的共聚物，从而得到一种土洛布特罗粘贴剂片，具有优异的土洛布特罗从压敏粘合剂层中的释放和皮肤渗透性能，低皮肤刺激性和优异的安全性。
• POLYMERIZABLE AMIDO-CONTAINING ORGANOSILICON COMPOUNDS, SILICON-CONTAINING POLYMERS AND BIOMEDICAL DEVICES THEREFROM
  申请人：Saxena Anubhav

  公开号：US20150011670A1

  公开（公告）日：2015-01-08

  There is provided a fast curing composition comprising an alpha, beta-unsaturated amido-containing organosilicon compound, useful in making water absorbing silicone-hydrogel films for biomedical devices, such as contact lens, and a process for producing these monomers. This invention also provides for hydrogels made from the alpha, beta-unsaturated amido-containing organosilicon compound described herein.

  本发明提供了一种快速固化的组合物，包括一种含有α，β-不饱和酰胺的有机硅化合物，用于制造生物医学设备（如隐形眼镜）的吸水性硅-水凝胶膜，并提供了制造这些单体的过程。本发明还提供了由本文所述的α，β-不饱和酰胺含有的有机硅化合物制成的水凝胶。
• A continuous process for preparation of highly rigid propylene-ethylene block copolymers
  申请人：CHISSO CORPORATION

  公开号：EP0739917A1

  公开（公告）日：1996-10-30

  A continuous process for preparation of propylene-ethylene block copolymer suitable for moldings with high rigidity and high impact resistance are provided, which process is a continuous process for preparation of highly rigid propylene-ethylene block copolymers, wherein propylene and ethylene are polymerized in the specified 2 steps with use of a catalyst system comprising (A) a solid catalyst component containing Ti, Mg, halogen and polyvalent carboxylic ester, (B) an organic aluminium compound, as well as (C) an organic silicon compound expressed by the general formula R4xR5ySi(OR6)z (wherein, x+y+z=4), and wherein the ratio between the maximum value and the minimum value of MFR(1)) is0.1 ≦ Log(MFR(h)/MFR(l)) ≦ 1, and the ratio between the average MFR(i) and MFR(ii) in the subsequent polymerization procedure (II) containing ethylene in a relatively large amount which is carried out by adding the glycol type compound is3 ≦ Log(MFR(i)/MFR(ii)) ≦ 7. The product having less fish eye and high impact resistant value was obtained from the copolymer according to the invention.

  提供了一种制备丙烯-乙烯嵌段共聚物的连续工艺，该工艺适用于具有高刚性和高抗冲击性的模塑件，该工艺是制备高刚性丙烯-乙烯嵌段共聚物的连续工艺，其中丙烯和乙烯在指定的 2 个步骤中聚合，使用的催化剂体系包括(A)固体催化剂组分，其中含有钛、镁、卤素和多价羧酸酯；(B)有机铝化合物；以及(C)由通式 R4xR5ySi(OR6) 表示的有机硅化合物、镁、卤素和多价羧酸酯的固体催化剂组分，(B) 有机铝化合物，以及(C) 由通式 R4xR5ySi(OR6)z 表示的有机硅化合物（其中，x+y+z=4），其中 MFR(1) 的最大值和最小值之间的比率为 0.1 ≦ Log(MFR(h)/MFR(l)) ≦ 1，通过添加乙二醇型化合物进行的含有相对大量乙烯的后续聚合程序（II）中的平均 MFR(i) 和 MFR(ii) 之间的比率为3 ≦ Log(MFR(i)/MFR(ii)) ≦ 7。 根据本发明的共聚物可获得鱼眼少、抗冲击值高的产品。