sulfachloropyridazine sodium | 23282-55-5

• 物质功能分类: 医药中间体 - 杂环化合物 - 哒嗪类化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sulfachloropyridazine sodium
• 英文别名: Prinzone；sodium;(4-aminophenyl)sulfonyl-(6-chloropyridazin-3-yl)azanide
• CAS: 23282-55-5
• 化学式: C₁₀H₈ClN₄O₂S*Na
• 分子量: 306.708
• InChiKey: ODWMXYHUKDMPTR-UHFFFAOYSA-N

物化性质

• 溶解度：
  DMSO（少许）、甲醇（少许）、水（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.89
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.3
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 安全说明：
  S36/37
• 危险类别码：
  R43
• 海关编码：
  2935009090
• 储存条件：
  室温

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Sulfachloropyridazine sodium
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Sulfachloropyridazine sodium
CAS number: 23282-55-5

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C10H8ClN4NaO2S
Molecular weight: 306.7

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, sulfur oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

药理作用

抗菌谱类似于磺胺间甲氧嘧啶，但抗菌作用略弱。它通过阻断微生物四氢叶酸的合成发挥广谱抗菌作用，能够抵抗革兰氏阳性菌和革兰氏阴性菌。内服1-3小时内血药浓度达到最高值。

此药物属于磺胺类药物，主要用于治疗畜禽（包括猪和鸡）的大肠杆菌和巴氏杆菌感染。

注意事项

(1) 蛋鸡产蛋期内禁用；反刍动物禁用。 (2) 不得作为饲料添加剂长期应用。 (3) 其他注意事项请参见磺胺类药物的前言部分。

不良反应

本品不良反应较少，偶有轻度胃肠道反应如恶心、食欲不振，以及过敏性皮疹和白细胞减少等现象。

用途

该药物作为禽畜消炎抗菌药，主要用于治疗鸡的大肠杆菌、葡萄球菌感染以及白冠病、鸡霍乱及伤寒病等多种传染病。

反应信息

• 作为反应物：
  描述：

  4-acetoxybenzoyl chloride 、 sulfachloropyridazine sodium 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 25.5h， 以76%的产率得到4-((4-(N-(6-chloropyridazin-3-yl)sulfamoyl)phenyl)carbamoyl)phenyl acetate
  参考文献：
  名称：

  Study on the synthesis of sulfonamide derivatives and their interaction with bovine serum albumin

  摘要：

  三种磺胺类衍生物(SAD)首先由对羟基苯甲酸和磺胺类药物(磺胺二甲嘧啶、磺胺甲恶唑和磺胺氯哒嗪钠)合成,并通过元素分析、1H NMR和MS进行表征。在模拟生理条件下,使用紫外-可见吸收光谱、荧光光谱、时间分辨荧光光谱和圆二色谱研究牛血清白蛋白(BSA)与SAD的相互作用。实验结果表明,SAD通过静态猝灭过程有效地淬灭了BSA的内在荧光。热力学参数表明,氢键和范德华力是BSA与两种SAD[4-((4-(N-(4,6-二甲基嘧啶-2-基)磺酰胺)苯基)氨基甲酰)苯甲酸酯和4-((4-(N-(5-甲基异恶唑-3-基)磺酰胺)苯基)氨基甲酰)苯甲酸酯]之间的主要分子间作用力,但疏水作用力在BSA与4-((4-(N-(6-氯哒嗪-3-基)磺酰胺)苯基)氨基甲酰)苯甲酸酯的结合过程中起主要作用。此外,使用同步荧光光谱和圆二色谱研究了SAD对BSA构象的影响。分子建模结果表明,SAD位于BSA的IIA亚域中。版权所有 © 2014 John Wiley & Sons, Ltd。

  DOI：

  10.1002/bio.2725
• 作为产物：
  描述：

  3,6-二氯哒嗪 、 磺胺 在 sodium 作用下， 以 二甲基亚砜 、 水 为溶剂， 60.0~100.0 ℃ 、300.01 kPa 条件下， 反应 18.0h， 以99.5%的产率得到sulfachloropyridazine sodium
  参考文献：
  名称：

  一种磺胺氯哒嗪钠的合成方法

  摘要：

  本发明涉及一种磺胺氯哒嗪钠的合成方法，其特征在于，包括如下步骤：步骤S1、向反应釜中依次加入磺胺、3,6‑二氯哒嗪和高沸点溶剂，然后再向其中加入负载碱性催化剂，在0.3‑1.2MPa，100‑160℃下搅拌10‑16小时后得到第一混合液；步骤S2、将经过步骤S1制成的第一混合液抽滤除去溶剂；然后将除去溶剂后的产品溶于去离子水中，并向其中加入钠盐，在60‑80℃下搅拌反应8‑10小时，后过滤除去不溶物，然后将得到的溶液进行冷却结晶，过滤得到磺胺氯哒嗪钠。本发明公开的磺胺氯哒嗪钠的合成方法简单易行，原料来源丰富，价格低廉，制备效率高，产率更高，生产成本更低。

  公开号：

  CN111303044A

文献信息

• ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF
  申请人：Meng Charles Q.

  公开号：US20140142114A1

  公开（公告）日：2014-05-22

  The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 and X 8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

  本发明涉及以下式（I）的新型驱虫化合物： 其中 Y和Z分别是双环碳环或双环杂环基团，或者Y或Z中的一个是双环碳环或双环杂环基团，另一个是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，以及变量X 1 ，X 2 ，X 3 ，X 4 ，X 5 ，X 6 ，X 7 和X 8 如本文所定义。本发明还提供了包含本发明的驱虫化合物的兽药组合物，以及它们用于治疗和预防动物寄生虫感染的用途。
• [EN] ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS<br/>[FR] COMPOSÉS DEPSIPEPTIDIQUES ANTHELMINTHIQUES
  申请人：MERIAL INC

  公开号：WO2018093920A1

  公开（公告）日：2018-05-24

  The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the naturally occurring cyclic depsipeptide PF1022A. The invention also provides compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

  本发明提供了公式（I）的环状脱氨肽化合物，其中至少一个碳原子的立体化学构型与自然存在的环状脱氨肽PF1022A的基团Cy1、Cy2、R1、R2、R3、R4、Ra和Rb相比发生了倒置。该发明还提供了包含这些化合物的组合物，对危害动物的寄生虫具有有效性。这些化合物和组合物可用于对抗哺乳动物和鸟类体内或体表的寄生虫。该发明还提供了一种改进的方法，用于根除、控制和预防鸟类和哺乳动物的寄生虫感染。
• [EN] ANTI PARASITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME<br/>[FR] DIHYDROAZOLES ANTIPARASITAIRES ET COMPOSITIONS LES INCLUANT
  申请人：MERIAL LTD

  公开号：WO2011075591A1

  公开（公告）日：2011-06-23

  The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

  本发明涉及式(I)的新型二氢咪唑及其盐：其中R1、A1、A2、G、X和Y如描述中所定义，以及它们的组合物、制备方法以及它们用于预防或治疗动物寄生虫感染或寄生虫侵袭以及作为杀虫剂的用途。
• [EN] PESTICIDAL AND PARASITICIDAL PYRAZOLE-ISOXAZOLINE COMPOUNDS<br/>[FR] COMPOSÉS DE PYRAZOLE-ISOXAZOLINE À ACTIVITÉ PESTICIDE ET PARASITICIDE
  申请人：MERIAL INC

  公开号：WO2019036407A1

  公开（公告）日：2019-02-21

  The present invention relates to pesticidal and parasiticidal isoxazoline of formula (I) and salts thereof: wherein variables R1, P, Y and Q are described herein are as defined in the description. The invention also relates to parasiticidal and pesticidal compositions comprising the isoxazoline compounds of formula (I), processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

  本发明涉及式(I)的杀虫剂和杀寄生虫的异恶唑啉及其盐：其中变量R1、P、Y和Q如本文所述，在描述中定义。本发明还涉及包含式(I)异恶唑啉化合物的杀寄生虫和杀虫组合物，其制备过程及其用于预防或治疗动物寄生虫感染或侵袭以及作为杀虫剂的应用。
• ANTIPARISITIC DIHYDROAZOLE COMPOUNDS AND COMPOSITIONS COMPRISING SAME
  申请人：Le Hir de Fallois Loic Patrick

  公开号：US20110152312A1

  公开（公告）日：2011-06-23

  The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R 1 , A 1 , A 2 , G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

  本发明涉及式(I)的新型二氢咪唑及其盐： 其中R1、A1、A2、G、X和Y如描述中所定义，以及它们的组合物、制备方法以及它们在预防或治疗动物寄生虫感染或寄生虫侵袭以及作为杀虫剂中的用途。