N,N-Diaethyl-2,3-dimethyl-anilin | 3995-36-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-Diaethyl-2,3-dimethyl-anilin
• 英文别名: N,N-diethyl-2,3-dimethylaniline
• CAS: 3995-36-6
• 化学式: C₁₂H₁₉N
• 分子量: 177.29
• InChiKey: QWVUDAMNCWEFBO-UHFFFAOYSA-N

物化性质

• 沸点：
  259.4±9.0 °C(Predicted)
• 密度：
  0.918±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-溴-1,2-二甲苯 、 二乙胺 在 potassium amide 作用下， 反应 2.0h， 生成 N,N-Diaethyl-2,3-dimethyl-anilin 、 N,N-diethyl-3,4-dimethylaniline
  参考文献：
  名称：

  Reaction of 4-bromo-1,2-dimethylbenzene with various nucleophiles via aryne reaction

  摘要：

  DOI：

  10.1021/jo00376a020

文献信息

• [EN] NOVEL ARYLALKYL PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS ARYLALKYLE PYRAZOLE UTILES EN TANT QU'INHIBITEURS DE L'INDOLÉAMINE 2,3-DIOXYGÉNASE
  申请人：MERCK SHARP & DOHME

  公开号：WO2020081381A1

  公开（公告）日：2020-04-23

  Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

  本文披露了化合物的结构式（I），这些化合物是IDO酶的抑制剂：本文还披露了这些化合物在潜在治疗或预防IDO相关疾病或紊乱中的用途。本文还披露了包含这些化合物的组合物。此外，本文还披露了这些组合物在潜在治疗或预防IDO相关疾病或紊乱中的用途。
• [EN] NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS DE PIPERAZINE AMIDE SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE L'INDOLÉAMINE 2,3-DIOXYGÉNASE (IDO)
  申请人：MERCK SHARP & DOHME

  公开号：WO2020112581A1

  公开（公告）日：2020-06-04

  Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

  本文披露了一种化合物，其化学式为（I），可以作为IDO酶的抑制剂：（I）。本文还披露了这些化合物在潜在的治疗或预防IDO相关疾病或紊乱中的用途。本文还披露了包含这些化合物的组合物。此外，本文还披露了这些组合物在潜在的治疗或预防IDO相关疾病或紊乱中的用途。
• Measurement of alpha-amylase activity
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：EP0104780A1

  公开（公告）日：1984-04-04

  Measurement of a-amylase activity is conducted by using a modified amylose having one carboxymethyl group or a salt thereof per 6 to 36 glucose units in amylose as , substrate and using a coupling enzyme of glucoamylase or α-glucosidase to produce glucose and quantitatively determining the glucose produced by a known method. When a special reaction stopper for the coupling enzyme glucoamylase is used, fixed-time assay becomes possible.

  测定 a-淀粉酶活性的方法是：以淀粉中每 6 至 36 个葡萄糖单位含有一个羧甲基基团或其盐的改性淀粉为底物，使用葡萄糖淀粉酶或 α-葡萄糖苷酶偶联酶产生葡萄糖，并用已知方法定量测定所产生的葡萄糖。如果使用葡萄糖淀粉酶偶联酶的特殊反应塞，就可以进行固定时间测定。
• PROCESS FOR DECOMPOSING ASCORBIC ACID
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD.

  公开号：EP0148275A1

  公开（公告）日：1985-07-17

  A novel process for decomposing ascorbic acid to produce H2O and dehydroascorbic acid instead of producing H2O2 which comprises mixing a monovalent or divalent copper ion, peroxidase, and at least one compound selected from the group consisting of: (1) 4-aminoantipyrine; (2) 3-methylbenzothiazolinone hydrazone; (3) 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid); (4) triphenylmethane leuco dyes; (5) phenolic compounds; (6) aniline compounds; and (7) naphthol compounds.

  一种分解抗坏血酸以产生 H2O 和脱氢抗坏血酸而不是产生 H2O2 的新工艺，它包括将一价或二价铜离子、过氧化物酶和至少一种选自以下组别的化合物混合在一起：(1) 4-氨基安替比林；(2) 3-甲基苯并噻唑啉酮腙；(3) 2,2'-偶氮双(3-乙基苯并噻唑啉-6-磺酸)；(4) 三苯甲烷白基染料；(5) 酚类化合物；(6) 苯胺化合物；(7) 萘酚化合物。
• Mono-tertiary-alkylated toluenediamine and derivatives
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0177916A1

  公开（公告）日：1986-04-16

  This invention relates to a class of tertiary-alkyltoluenediamines having alkyl groups ortho to an amine group. More particularly the aromatic diamines are represented by the formulas: wherein R1, R2 and R3 are C1-3 alkyl groups or R2 and R3 are combined to form a C5-6 membered ring. The above described alkylated aromatic diamines have been found to be well suited for use as a chain extender in forming polyurethane/urea elastomer systems and the mono tert-butyltoluenediamine isomers have been found to be non- mutagenic in the Ames test.

  本发明涉及一类叔烷基甲苯二胺，其烷基正交于一个胺基。 更具体地说，芳香族二胺由以下公式表示：其中 R1、R2 和 R3 为 C1-3 烷基，或 R2 和 R3 组合形成一个 C5-6 分子环。 上述烷基化芳香族二胺已被发现非常适合用作聚氨酯/尿素弹性体系统的扩链剂，并且单叔丁基甲苯二胺异构体在艾姆斯试验中被发现无诱变性。