N,N-diethyl-3,4-dimethylaniline | 105336-31-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethyl-3,4-dimethylaniline
• CAS: 105336-31-0
• 化学式: C₁₂H₁₉N
• mdl: MFCD22083316
• 分子量: 177.29
• InChiKey: JNMWNOFTCDEJHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-硝基邻二甲苯 、 3-戊酮 在 palladium on activated charcoal 、 platinum on activated charcoal 、 氢气 作用下， 65.0~80.0 ℃ 、750.01 kPa 条件下， 反应 6.0h， 以99.1%的产率得到N,N-diethyl-3,4-dimethylaniline
  参考文献：
  名称：

  一种N-(1-乙基丙基)-3,4-二甲基苯胺连续化 生产装置及方法

  摘要：

  本发明公开了N‑(1‑乙基丙基)‑3,4‑二甲基苯胺的连续化生产装置及方法，邻二甲苯和硝硫混酸在硝化系统中进行硝化反应，反应液依次经过第一分相槽、迷宫洗涤系统、精馏系统进行精馏处理，收集4‑硝基邻二甲苯与3‑戊酮在氢化反应器内进行催化氢化反应，再经降膜蒸发系统制得N‑(1‑乙基丙基)‑3,4‑二甲基苯胺。本发明提供的生产装置的各物料实现循环回用，降低生产成本，且有效提高单批生产的原料转化率，降低废酸废水量。

  公开号：

  CN105348113B

文献信息

• Visible‐Light‐Enabled Direct Decarboxylative N‐Alkylation
  作者：Vu T. Nguyen、Viet D. Nguyen、Graham C. Haug、Ngan T. H. Vuong、Hang T. Dang、Hadi D. Arman、Oleg V. Larionov

  DOI：10.1002/anie.201916710

  日期：2020.5.11

  development of efficient and selective C-N bond-forming reactions from abundant feedstock chemicals remains a central theme in organic chemistry owing to the key roles of amines in synthesis, drug discovery, and materials science. Herein, we present a dual catalytic system for the N-alkylation of diverse aromatic carbocyclic and heterocyclic amines directly with carboxylic acids, by-passing their preactivation

  由于胺在合成、药物发现和材料科学中的关键作用，从丰富的原料化学品中开发高效、选择性的 CN 键形成反应仍然是有机化学的中心主题。在此，我们提出了一种双催化系统，用于直接用羧酸对多种芳香族碳环和杂环胺进行 N-烷基化，绕过它们作为氧化还原活性酯的预活化。该反应通过可见光驱动、吖啶催化的脱羧作用实现，提供了获得 N-烷基化仲苯胺和叔苯胺以及 N-杂环的途径。其他例子，包括双烷基化、安装代谢稳定的氘代甲基以及串联环形成，进一步证明了直接脱羧烷基化（DDA）反应的潜力。
• RESIN COMPOSITION, OPTICAL FILTER, IMAGE DISPLAY DEVICE, SOLID-STATE IMAGING ELEMENT, AND COLORANT MIXTURE
  申请人：FUJIFILM Corporation

  公开号：US20210277249A1

  公开（公告）日：2021-09-09

  Provided are a resin composition including a colorant and a resin, in which the colorant contains two or more squarylium colorants represented by Formula (1) below, at least one of the squarylium colorants is a squarylium colorant having a hydrogen-bonding group, which is represented by Formula (2) below, and a colorant mixture consisting of the two or more squarylium colorants, which is included in the resin composition, has a maximum absorption wavelength in a wavelength range of 400 nm to 700 nm; an optical filter; a liquid crystal display device; a solid-state imaging element; and a colorant mixture.

  提供了一种树脂组合物，其中包括一种颜料和一种树脂，其中该颜料包含以下式（1）所代表的两种或两种以上的方三唑基颜料，其中至少一种方三唑基颜料是具有氢键结合基团的方三唑基颜料，其由以下式（2）表示，并且包含在树脂组合物中的两种或两种以上的方三唑基颜料的颜料混合物在波长范围为400纳米至700纳米的波长范围内具有最大吸收波长；光学滤光片；液晶显示装置；固态成像元件；以及颜料混合物。
• METHOD FOR PRODUCING CYANOACETIC ACID, METHOD FOR PRODUCING CYANOACETIC ACID DERIVATIVE AND METHOD FOR PRODUCING METAL CONTAINING COMPOUND
  申请人：IKEMIZU Dai

  公开号：US20130253213A1

  公开（公告）日：2013-09-26

  Provided is a method for producing cyanoacetic acid in a hydrolysis reaction of a predetermined cyanoacetate in the presence of an acid catalyst. Further, are provided methods for producing a cyanoacetic acid derivative and a metal containing compound by using the produced cyanoacetic acid as a staring material. Herein, the method for producing cyanoacetic acid enables the content of a malonic acid byproduct generated in the hydrolysis reaction to be greatly lowered, allowing the produced cyanoacetic acid to be used as a starting material without any purification treatments. Those advantageous effects result in the great improvement in the purity and yields of the cyanoacetic acid derivative and the metal containing compound produced by said cyanoacetic acid. Accordingly, the above mentioned methods make it possible to produce cyanoacetic acid, the cyanoacetic acid derivative and the metal containing compound, as excellent in the productivity and economical efficiency.

  提供了一种在酸催化剂存在下，通过水解预定的氰乙酸盐生成氰乙酸的方法。此外，提供了利用生成的氰乙酸作为起始物质来生产氰乙酸衍生物和含金属化合物的方法。在这种生产氰乙酸的方法中，使得在水解反应中生成的丙二酸副产物的含量大大降低，使得生成的氰乙酸可以作为起始物质而无需任何纯化处理。这些有利效果导致了通过该氰乙酸生成的氰乙酸衍生物和含金属化合物的纯度和产量显著提高。因此，上述方法使得能够以高生产率和经济效益生产氰乙酸、氰乙酸衍生物和含金属化合物。
• N-Phenyloxamide derivatives
  申请人：YAMAGUCHI Youichi

  公开号：US20080249175A1

  公开（公告）日：2008-10-09

  A compound represented by the following general formula (I) or a salt thereof, or a hydrate thereof or a solvate thereof having an inhibitory action against plasminogen activator inhibitor-1 (PAI-1): wherein R 1 represents a C 6-10 aryl group; or a C 6-10 aryl group substituted with a group or groups selected from the group consisting of a halogen atom, cyano group, nitro group, a C 1-6 alkyl group, a halogenated C 1-6 alkyl group, a C 1-6 alkoxy group, a halogenated C 1-6 alkoxy group and a C 1-6 alkylsulfanyl group, R 2 represents a C 6-10 aryl group; or a C 6-10 aryl group substituted with a group or groups selected from the group consisting of a halogen atom, hydroxy group, a C 1-6 alkyl group, a halogenated C 1-6 alkyl group, a C 1-6 alkoxy group, a halogenated C 1-6 alkoxy group, a C 1-6 alkylsulfanyl group and phenyl group, X represents a single bond or oxygen atom, Z represents a phenylene group or a substituted phenylene group, m represents 0 or 1.

  由以下一般式(I)表示的化合物或其盐，或其水合物或其溶剂合物，具有对纤溶酶原激活酶抑制剂-1（PAI-1）的抑制作用：其中R1表示一个C6-10芳基团；或一个C6-10芳基团，该芳基团取代为从卤原子、氰基、硝基、C1-6烷基、卤代C1-6烷基、C1-6烷氧基、卤代C1-6烷氧基和C1-6烷基硫基等组成的组或组合物，R2表示一个C6-10芳基团；或一个C6-10芳基团，该芳基团取代为从卤原子、羟基、C1-6烷基、卤代C1-6烷基、C1-6烷氧基、卤代C1-6烷氧基、C1-6烷基硫基和苯基等组成的组或组合物，X表示一个单键或氧原子，Z表示一个苯基或取代苯基，m表示0或1。
• RESIN COMPOSITION, FILM, OPTICAL FILTER, IMAGE DISPLAY DEVICE, SOLID-STATE IMAGING ELEMENT, AND COMPOUND
  申请人：FUJIFILM Corporation

  公开号：US20200369890A1

  公开（公告）日：2020-11-26

  Provided are a resin composition including a compound represented by Formula (1) and a resin, a film and a filter including the resin composition, a liquid crystal display device and a solid-state imaging element including the filter, and a compound suitable as a light absorbing component of the resin composition and the filter. In Formula (1), Dye represents a colorant structural part obtained by removing n1 hydrogen atoms from a squarylium compound having a specific structure. Q 1 is a structural part in which energy levels of a highest occupied molecular orbital and a lowest unoccupied molecular orbital satisfy a specific condition. L 1 represents a divalent linking group and n1 represents an integer of 1 to 4.

  提供了一种含有由化学式（1）表示的化合物和树脂的树脂组合物，以及包括该树脂组合物的膜和过滤器，包括该过滤器的液晶显示装置和固态成像元件，以及一种适用于作为树脂组合物和过滤器的吸光成分的化合物。在公式（1）中，Dye表示通过从具有特定结构的方芘化合物中去除n1个氢原子而获得的着色剂结构部分。Q1是一种结构部分，其中最高占据分子轨道和最低未占据分子轨道的能级满足特定条件。L1表示二价连接基团，n1表示1至4的整数。