O³-β-D-Glucopyranosyl-O²-α-L-rhamnopyranosyl-D-galactose | 528-40-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: O³-β-D-Glucopyranosyl-O²-α-L-rhamnopyranosyl-D-galactose
• 英文别名: Rha(a1-2)[Glc(b1-3)]aldehydo-Gal；(2R,3S,4S,5R)-4,5,6-trihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyhexanal
• CAS: 528-40-5
• 化学式: C₁₈H₃₂O₁₅
• 分子量: 488.443
• InChiKey: OZIOWHWTZWIMCZ-FUIISSIDSA-N

物化性质

• 沸点：
  911.5±65.0 °C(Predicted)
• 密度：
  1.68±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -6.1
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  256
• 氢给体数：
  10
• 氢受体数：
  15

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯仿 、 氢溴酸 、 溶剂黄146 作用下， 生成 O³-β-D-Glucopyranosyl-O²-α-L-rhamnopyranosyl-D-galactose
  参考文献：
  名称：

  Kuhn et al., Chemische Berichte, 1955, vol. 88, p. 1492,1498

  摘要：

  DOI：

文献信息

• LIPID MEMBRANE STRUCTURE FOR siRNA INTRACELLULAR DELIVERY
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US20170273905A1

  公开（公告）日：2017-09-28

  A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (R 1 and R 2 represent CH 3 —(CH 2 ) n —CH═CH—CH 2 —CH═CH—(CH 2 ) m —, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and R 3 and R 4 represent a C 1-4 alkyl group or a C 2-4 alkenyl group.

  一种脂质膜结构，其中包含一种siRNA并含有一种化合物(I)作为脂质成分（其中R1和R2代表CH3-（CH2）n-CH═CH- -CH═CH-（ ）m-，n表示3至5的整数，m表示6至10的整数，p表示2至7的整数，R3和R4代表C1-4烷基或C2-4烯基）。
• Lipid membrane structure for intracellular delivery of siRNA
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US10182987B2

  公开（公告）日：2019-01-22

  A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (R1 and R2 represent CH3—(CH2)n—CH═CH—CH2—CH═CH—(CH2)m—, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and R3 and R4 represent a C1-4 alkyl group or a C2-4 alkenyl group.

  一种脂质膜结构，在其内部封装 siRNA，并含有式 (I) 的脂质化合物作为脂质成分（R1 和 R2 代表 CH3-(CH2)n-CH═CH- -CH═CH-( )m-，n 代表 3 至 5 的整数，m 代表 6 至 10 的整数，p 代表 2 至 7 的整数，R3 和 R4 代表 C1-4 烷基或 C2-4 烯基）。
• LIPID MEMBRANE STRUCTURE HAVING INTRANUCLEAR MIGRATING PROPERTY
  申请人：Harashima Hideyoshi

  公开号：US20130122054A1

  公开（公告）日：2013-05-16

  A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell.
• US8981044B2
  申请人：——

  公开号：US8981044B2

  公开（公告）日：2015-03-17