[1,1'-biphenyl]-4-yl(4-hydroxyphenyl)methanone | 3558-83-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [1,1'-biphenyl]-4-yl(4-hydroxyphenyl)methanone
• 英文别名: 4-biphenyl 4-hydroxyphenyl ketone；4-hydroxy-4'-phenyl-benzophenone；4-Hydroxy-4'-phenyl-benzophenon；Methanone, [1,1'-biphenyl]-4-yl(4-hydroxyphenyl)-；(4-hydroxyphenyl)-(4-phenylphenyl)methanone
• CAS: 3558-83-6
• 化学式: C₁₉H₁₄O₂
• 分子量: 274.319
• InChiKey: OIVKGWBVGFLUFY-UHFFFAOYSA-N

物化性质

• 熔点：
  186°C

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2914501900

反应信息

• 作为反应物：
  描述：

  [1,1'-biphenyl]-4-yl(4-hydroxyphenyl)methanone 在 溶剂黄146 、 肼 作用下， 以 吡啶 、 乙醇 为溶剂， 生成
  参考文献：
  名称：

  具有杀虫活性的二苯甲酮derivatives衍生物的合成及其构效关系。

  摘要：

  制备了广泛的二苯甲酮衍生物，并针对选定的咀嚼害虫进行了测试，从而分析了结构-活性关系。仅当芳环在4-位被卤素原子和三氟甲磺酸酯或全卤代烷氧基取代时，才发现良好的活性。相反，部分上的许多取代基导致活性化合物，用酰基型取代基可获得最佳结果。在针对斜纹夜蛾的半田间试验中证实了最佳代表的出色的实验室和温室活性。

  DOI：

  10.1002/1526-4998(200102)57:2<191::aid-ps275>3.0.co;2-o
• 作为产物：
  描述：

  联苯 在 三氯化铝 作用下， 以 二硫化碳 、 苯 为溶剂， 反应 4.0h， 生成 [1,1'-biphenyl]-4-yl(4-hydroxyphenyl)methanone
  参考文献：
  名称：

  Kumar, Shiv; Seth, M.; Bhaduri, A. P., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 2, p. 154 - 157

  摘要：

  DOI：

文献信息

• Catalytic Enantioselective House–Meinwald Rearrangement: Efficient Construction of All-Carbon Quaternary Stereocenters
  作者：Dengke Ma、Chun-Bao Miao、Jianwei Sun

  DOI：10.1021/jacs.9b07514

  日期：2019.9.4

  A catalytic asymmetric House‒Meinwald rearrangement for the synthesis of both cyclic and acyclic ketones is disclosed. From readily accessible racemic tetrasubstituted epoxides, this approach provides efficient access to chiral ketones bearing α all-carbon quaternary stereocenters with high enantiocontrol. The observation of positive non-linear effects and nontrivial kinetic feature provided important

  公开了一种用于合成环状酮和无环酮的催化不对称 House-Meinwald 重排。从容易获得的外消旋四取代环氧化物中，这种方法提供了有效获取带有 α 全碳四元立体中心且具有高对映控制的手性酮的途径。对正非线性效应和非平凡动力学特征的观察提供了对该机制的重要见解。
• Polyarylether
  申请人：——

  公开号：EP0194062A3

  公开（公告）日：1986-11-20

  A polyarylether includes repeating units of the structure IA. -Ph -CO -Ar' -CO -Ph -and of the structure wherein IA and IB are linked through ether linkages, Ph is phenylene, Ar' is a polyaromatic group such as biphenylene and Ar2 may be Ph or a polyaromatic group wherein two aromatic groups may be linked by -CO -or -SO2 -and at least some of the groups Ar2 contain -SO2 -. In preferred polymers, at least some of the structures IA are joined to each other or to an Ar2 group which does not contain -SO2-. The polymers typically have a glass transition temperature of ≧ 200°C and a melting temperature of ≧ 300°C and preferably ≦ 430°C. Polymers of this type have enhanced solvent resistance, even when essentially amorphous.

  聚芳基醚包括结构 IA.-Ph -CO -Ar' -CO -Ph - 的重复单元，其中 IA 和 IB 通过醚键连接，Ph 为亚苯基，Ar' 为多芳香族基团（如联苯），Ar2 可以是 Ph 或多芳香族基团，其中两个芳香族基团可以通过 -CO - 或 -SO2 - 连接，并且至少部分基团 Ar2 含有 -SO2 -。 在优选聚合物中，至少部分结构 IA 相互连接或与不含 -SO2- 的 Ar2 基团连接。 此类聚合物的玻璃化转变温度通常≧ 200°C，熔化温度≧ 300°C，最好≦ 430°C。
• Preparation process of fluorine subsituted aromatic compound
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1013629A1

  公开（公告）日：2000-06-28

  A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylaminodifluoromethane compound, for example, 2,2'-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.

  本发明公开了一种氟取代芳香族化合物的制备工艺，该工艺包括使具有羟基的芳香族化合物的碱金属盐或碱土金属盐与有机氟化剂反应。作为氟化剂的代表，举例说明了一种双二烷基氨基二氟甲烷化合物，例如 2,2'-二氟-1,3-二甲基咪唑烷。 根据该工艺，工业上有用的氟化芳烃化合物，例如氟苯、氟取代的二苯甲酮、氟取代的二元砜，无需特定设备即可轻松制备，经济实惠。
• Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4′-Y-(1,1′-biphenyl)-4-yl]-N,N-dimethyl-3-(4-X-phenyl)-2-propen-1-amine derivatives
  作者：A de Souza

  DOI：10.1016/s0223-5234(01)01263-6

  日期：2001.10

  The derivatives of 3-(4'-bromo-[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains or Mycobacterium sp. (ATCC) and V. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction to measure the cellular viability. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
• Synthesis and structure–activity relationship for new series of 4-Phenoxyquinoline derivatives as specific inhibitors of platelet-derived growth factor receptor tyrosine kinase
  作者：Kazuo Kubo、Shin-ichi Ohyama、Toshiyuki Shimizu、Atsuya Takami、Hideko Murooka、Tsuyoshi Nishitoba、Shinichiro Kato、Mikio Yagi、Yoshiko Kobayashi、Noriko Iinuma、Toshiyuki Isoe、Kazuhide Nakamura、Hiroshi Iijima、Tatsushi Osawa、Toshio Izawa

  DOI：10.1016/j.bmc.2003.08.020

  日期：2003.11

  We discovered a new series of 4-phenoxyquinoline derivatives as potent and selective inhibitors of the platelet-derived growth factor receptor (PDGFr) tyrosine kinase. We researched the highly potent and selective inhibitors on the basis of both PDGFr and epidermal growth factor receptor (EGFr) inhibitory activity. First, we found a compound, Ki6783 (1), which inhibited PDGFr autophosphorylation at 0.13 muM, but it did not inhibit EGFr autophosphorylation at 100 muM. After extensive explorations, we found the two desired compounds, Ki6896 (2) and Ki6945 (3), which are substituted by benzoyl and benzamide at the 4-position of the phenoxy group on 4-phenoxyquinoline, respectively. These inhibitory activities were 0.31 and 0.050 muM, respectively, but neither of them inhibited EGFr autophosphorylation at 100 M. We further investigated the profile of both compounds toward various tyrosine and serine/threonine kinases. The three compounds specifically inhibited PDGFr rather than the other kinases. (C) 2003 Elsevier Ltd. All rights reserved.