4-[3-(dimethylamino)-1-(4-phenylphenyl)prop-1-enyl]phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[3-(dimethylamino)-1-(4-phenylphenyl)prop-1-enyl]phenol
• 化学式: C₂₃H₂₃NO
• 分子量: 329.442
• InChiKey: ZAQQSTIAANFZPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.05
• 重原子数：
  25.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  23.47
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  4'-bromo-(1,1-'-biphenyl)-4-yl p-methoxyphenyl methanone 在 正丁基锂 、 三氯化铝 作用下， 以 四氢呋喃 、 正己烷 、 苯 为溶剂， 反应 4.0h， 生成 4-[3-(dimethylamino)-1-(4-phenylphenyl)prop-1-enyl]phenol
  参考文献：
  名称：

  Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4′-Y-(1,1′-biphenyl)-4-yl]-N,N-dimethyl-3-(4-X-phenyl)-2-propen-1-amine derivatives

  摘要：

  The derivatives of 3-(4'-bromo-[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains or Mycobacterium sp. (ATCC) and V. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction to measure the cellular viability. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(01)01263-6

文献信息

• Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4′-Y-(1,1′-biphenyl)-4-yl]-N,N-dimethyl-3-(4-X-phenyl)-2-propen-1-amine derivatives
  作者：A de Souza

  DOI：10.1016/s0223-5234(01)01263-6

  日期：2001.10

  The derivatives of 3-(4'-bromo-[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains or Mycobacterium sp. (ATCC) and V. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction to measure the cellular viability. (C) 2001 Editions scientifiques et medicales Elsevier SAS.