4'-bromo-(1,1-'-biphenyl)-4-yl p-methoxyphenyl methanone | 185410-09-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-bromo-(1,1-'-biphenyl)-4-yl p-methoxyphenyl methanone
• 英文别名: [4-(4-Bromophenyl)phenyl]-(4-methoxyphenyl)methanone
• CAS: 185410-09-7
• 化学式: C₂₀H₁₅BrO₂
• 分子量: 367.242
• InChiKey: YUZFNERFXLAMSU-UHFFFAOYSA-N

物化性质

• 沸点：
  499.2±35.0 °C(Predicted)
• 密度：
  1.345±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4'-bromo-(1,1-'-biphenyl)-4-yl p-methoxyphenyl methanone 在 三氯化铝 作用下， 以 苯 为溶剂， 反应 4.0h， 以100%的产率得到[1,1'-biphenyl]-4-yl(4-hydroxyphenyl)methanone
  参考文献：
  名称：

  Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4′-Y-(1,1′-biphenyl)-4-yl]-N,N-dimethyl-3-(4-X-phenyl)-2-propen-1-amine derivatives

  摘要：

  The derivatives of 3-(4'-bromo-[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains or Mycobacterium sp. (ATCC) and V. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction to measure the cellular viability. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

  DOI：

  10.1016/s0223-5234(01)01263-6
• 作为产物：
  描述：

  4-溴代联苯 、 对甲氧基苯甲酰氯 在 三氯化铝 作用下， 以 二硫化碳 为溶剂， 反应 8.0h， 以62%的产率得到4'-bromo-(1,1-'-biphenyl)-4-yl p-methoxyphenyl methanone
  参考文献：
  名称：

  Synthesis and biological activities of N,N-dimethyl-2-propen-1-amine derivatives

  摘要：

  The synthesis of several 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine derivatives is described. These compounds are potential trypanocide agents with relative low acute toxicities. The inhibition of growth of Escherichia cell by these drugs with different para-substitution on the phenyl moiety and their trypanocidal activities against epimastigote from Trypanosoma cruzi were investigated.

  DOI：

  10.1016/s0223-5234(97)89856-x

文献信息

• Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4′-Y-(1,1′-biphenyl)-4-yl]-N,N-dimethyl-3-(4-X-phenyl)-2-propen-1-amine derivatives
  作者：A de Souza

  DOI：10.1016/s0223-5234(01)01263-6

  日期：2001.10

  The derivatives of 3-(4'-bromo-[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains or Mycobacterium sp. (ATCC) and V. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction to measure the cellular viability. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
• Synthesis and biological activities of N,N-dimethyl-2-propen-1-amine derivatives
  作者：R De Conti、SMN Gimenez、M Haun、RA Pilli、SL De Castro、N Durán

  DOI：10.1016/s0223-5234(97)89856-x

  日期：1996.1

  The synthesis of several 3-(4'-bromo[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine derivatives is described. These compounds are potential trypanocide agents with relative low acute toxicities. The inhibition of growth of Escherichia cell by these drugs with different para-substitution on the phenyl moiety and their trypanocidal activities against epimastigote from Trypanosoma cruzi were investigated.