2-chloro-crotonic acid | 22038-56-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-chloro-crotonic acid
• 英文别名: 2-chloro-cis-crotonic acid；2-Chlor-cis-crotonsaeure；2-Chlor-crotonsaeure；Allo-α-chlor-crotonsaeure；α-Chlor-isocrotonsaeure；2-Chlor-but-2-ensaeure；2-Chlorocrotonic acid；(E)-2-chlorobut-2-enoic acid
• CAS: 22038-56-8
• 化学式: C₄H₅ClO₂
• 分子量: 120.535
• InChiKey: WMDBQMYVAIBBDH-NSCUHMNNSA-N

物化性质

• 熔点：
  100°C
• 沸点：
  148.96°C (rough estimate)
• 密度：
  1.2094 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloro-crotonic acid 在 二硫化碳 、 氯 作用下， 生成 2,2,3-trichloro-butyric acid
  参考文献：
  名称：

  Valentin, Chemische Berichte, 1895, vol. 28, p. 2663

  摘要：

  DOI：
• 作为产物：
  描述：

  (Z)-ethyl 2-chlorobut-2-enoate 在 氢氧化钾 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 15.0h， 生成 2-chloro-crotonic acid
  参考文献：
  名称：

  乙烯基酮作为双环[4.2.1]壬二烯酮的合成子†

  摘要：

  六种乙烯基乙烯酮（9a - 9f），其中五种为氯乙烯基乙烯酮（9a - e）（请参见方案2），是通过从相应的α，β-不饱和酰氯中1，HCl脱除HCl原位制备的，用实施的环戊二烯（2）或6,6-二甲基富勒烯（3）处理。由[2 + 2]环加成起源5 7-乙烯基取代的二环[3.2.0] -2-庚烯-6-酮（10 / 11）或三个4- Isopropylidenbicyclo [3.2.0] -2-庚烯-6-酮（12 / 13），其中，所述Stereoisomerenverhältnis 10：11乙烯酮取代基的大小会影响12:13或13:13。所述vinylketene cycloadducts 10 / 11和12 / 13含有一个应对系统，该系统在任何一个顺（10和12（）或抗构造11和13）的存在。在加热到140-190°，得到10 / 11分别12 / 13通过柯普重排，适当取代的双环[4

  DOI：

  10.1002/hlca.19820650203

文献信息

• Synthesis of Antibiotics. I. Synthesis of N-Substituted Compounds of Monochloroacylamide and Their Antitrichophyton Effect
  作者：Isoo Ito

  DOI：10.1248/cpb.14.561

  日期：——

  Thirteen kinds of monohalogenoacyl substituted aromatic derivatives were synthesized and tested their antitrichophyton effect. On anilide, Cl substitution of p-position is 30 times as strong as that of o-position, and Cl substitution is 33 times as strong as Br substitution. The double bond of acyl group of monohalogenoacyl substituted aromatic amide derivatives did not show strong fungical effect, and there was no difference of fungical effect between cis and trans.

  合成了13种单卤代乙酰基取代芳香族衍生物并测试了它们的抗癣菌效果。在苯胺中，氯在苯环对位的取代活性比在邻位的强30倍，氯的取代活性比溴强33倍。单卤代乙酰基取代芳香族酰胺衍生物酰基上的双键不呈现很强的抗菌效果，顺反式抗菌效果也没有差别。
• organolead Salts
  作者：Henry Gilman、Sydney M. Spatz、Martin J. Kolbezen

  DOI：10.1021/jo50016a013

  日期：1953.10
• Streambank and vegetation response to simulated cattle grazing
  作者：Warren P. Clary、John W. Kinney

  DOI：10.1672/0277-5212(2002)022[0139:savrts]2.0.co;2

  日期：2002.3

  Simulated grazing techniques were used to investigate livestock impacts on structural and vegetation characteristics of streambanks in central Idaho, USA. The treatments, continued over two years, consisted of no grazing, simulated moderate early summer grazing, simulated moderate mid-summer grazing, and simulated heavy season-long grazing. The moderate treatments depressed the streambank surface about 3 cm, while the heavy season-long treatment resulted in an 11.5-cm depression. There were no differences between the no-grazing and moderate-grazing treatments for change in stream width, bank angle, bank retreat, or root biomass. The heavy season-long treatment, however, produced significant changes in these variables. The amount of foliage biomass (i.e., kg ha(-1)) removed by treatment was similar between the two years of study for the moderate treatments. The foliage removed from the heavy season-long treatment plots greatly decreased in the second year as plant growth decreased. Ten months after the last treatment application, the average spring foliage growth was 20-43% lower on the moderate treatment plots and 51-87% lower on the heavy season-long treatment plots than on the untreated control plots.
• v.Auwers, Justus Liebigs Annalen der Chemie, 1923, vol. 432, p. 65
  作者：v.Auwers

  DOI：——

  日期：——
• Michael; Schulthess, Journal fur praktische Chemie (Leipzig 1954), 1892, vol. <2>46, p. 263
  作者：Michael、Schulthess

  DOI：——

  日期：——