N-(1H-indol-3-ylmethyl)-3-methylbutan-1-amine | 1247839-09-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(1H-indol-3-ylmethyl)-3-methylbutan-1-amine
• CAS: 1247839-09-3
• 化学式: C₁₄H₂₀N₂
• mdl: MFCD16662423
• 分子量: 216.326
• InChiKey: NHLNJTFBDXEYHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  27.8
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-吲哚甲醛 、 异戊胺 在 sodium cyanoborohydride 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 8.0h， 以100%的产率得到N-(1H-indol-3-ylmethyl)-3-methylbutan-1-amine
  参考文献：
  名称：

  Structure–activity relationships of small molecule inhibitors of RAGE-Aβ binding

  摘要：

  The Receptor for Advanced Glycation Endproducts ('RAGE') mediates transport of amyloid-beta peptide (A beta) into the brain, and is therefore an important target for the development of therapeutic agents for Alzheimer's disease. We describe structure activity relationships for inhibition of RAGE-A beta binding, derived from the analysis of a library of tertiary amides. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.079

文献信息

• Structure–activity relationships of small molecule inhibitors of RAGE-Aβ binding
  作者：Nathan T. Ross、Rashid Deane、Sheldon Perry、Benjamin L. Miller

  DOI：10.1016/j.tet.2013.05.079

  日期：2013.9

  The Receptor for Advanced Glycation Endproducts ('RAGE') mediates transport of amyloid-beta peptide (A beta) into the brain, and is therefore an important target for the development of therapeutic agents for Alzheimer's disease. We describe structure activity relationships for inhibition of RAGE-A beta binding, derived from the analysis of a library of tertiary amides. (C) 2013 Elsevier Ltd. All rights reserved.