(E)-4-(2-methoxyethoxy)-4-oxobut-2-enoic acid | 442842-74-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-4-(2-methoxyethoxy)-4-oxobut-2-enoic acid
• CAS: 442842-74-2
• 化学式: C₇H₁₀O₅
• 分子量: 174.153
• InChiKey: ZOVIVPPZCMSLMJ-NSCUHMNNSA-N

物化性质

• 沸点：
  304.7±22.0 °C(Predicted)
• 密度：
  1.224±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (E)-4-(2-methoxyethoxy)-4-oxobut-2-enoic acid 在 氯化亚砜 作用下， 反应 2.0h， 生成 2-methoxyethyl (E)-4-chloro-4-oxobut-2-enoate
  参考文献：
  名称：

  Characteristics of an RNA Diels−Alderase Active Site

  摘要：

  The active site components and substrate specificity of an RNA Diels-Alderase (DA22) were investigated. Diels-Alderase activity was found to be highly dependent on a unique 5-position pyridyl modified uridine. Even closely related pyridyl modifications failed to yield active catalysts. Substrate specificity of this Diels-Alderase was remarkable. Experiments with alternative diene and dienophile substrates showed the active site of the Diels-Alderase to be highly discriminating, even against molecules of similar reactivity and structure. Inhibition studies with a series of product analogues established that the RNA recognizes functional components in and around the reaction center of both the diene and the dienophile. Taken together, these results suggest that DA22 can fold into a structure that produces an intricate metal/ligand dependent active site capable of highly specific molecular recognition.

  DOI：

  10.1021/ja983989m
• 作为产物：
  描述：

  马来酸酐 、 乙二醇甲醚 以 四氢呋喃 为溶剂， 以1.3 g的产率得到(E)-4-(2-methoxyethoxy)-4-oxobut-2-enoic acid
  参考文献：
  名称：

  Kras-G12C抑制剂杂环化合物

  摘要：

  本申请涉及一类式I所示Kras‑G12C抑制剂杂环化合物，及其制备方法和该类化合物在肿瘤疾病，如肺癌、结直肠癌和胰腺癌等中的预防和治疗用途。在制备过程中，通过SN2反应、上保护、偶联反应、脱保户、缩合反应等一系列反应，得到通式化合物I。

  公开号：

  CN113004269A

文献信息

• Heat-curable silicone compositions comprising fumarate cure-control additive and use thereof
  申请人：DOW CORNING CORPORATION

  公开号：EP0297746A2

  公开（公告）日：1989-01-04

  Compositions which cure by a platinum-catalyzed reaction between silicon-bonded hydrogen atoms and silicon-­bonded, aliphatically unsaturated hydrocarbon radicals have improved pot-life and cure-rate characteristics when a catalyst-inhibiting amount of a diorgano fumarate compound is added to the composition. Solventless coating compositions containing a dialkyl fumarate, a methylhydrogenpolysiloxane and a methylpolysiloxane bearing hexenyl radicals are particularly useful as adhesive-release coatings for acrylic-based pressure sensitive adhesives, applied in-line.

  通过硅键氢原子和硅键脂肪族不饱和烃基之间的铂催化反应而固化的组合物，如果在组合物中加入一定量的富马酸二烷基酯化合物的催化剂抑制剂，其固化寿命和固化速率特性都会得到改善。含有富马酸二烷基酯、含己烯基的甲基氢聚硅氧烷和甲基聚硅氧烷的无溶剂涂料组合物，特别适用于丙烯酸基压敏胶的粘合剂脱模涂料。
• Coating varnish composition and antifouling coating composition
  申请人：Hitachi Chemical Co., Ltd.

  公开号：EP0711813A2

  公开（公告）日：1996-05-15

  A coating varnish composition comprising a biodegradable polymer (A) comprising one or more kinds of constituent units (b) represented by the general formula (I), (II) or (III) and one or more other kinds of constituent units (a) capable of imparting bio-degradability: wherein in the formula (I), R¹ and R are independently a hydrogen atom, a chlorine atom, a bromine atom, a methyl group, an ethyl group or a phenyl group; in the formula (II), R³ and R⁴ are independently a hydrogen atom, a chlorine atom, a bromine atom, or a substituted or unsubstituted methyl or ethyl group; in the formula (III), R⁵ and R⁶ are independently a hydrogen atom, a methyl group or an ethyl group, and R⁷ is a straight, branched or cyclic alkyl group, an aryl group, a heterocyclic group or an aralkyl group, which may have one or more substituents.

  一种涂料清漆组合物，包含一种可生物降解聚合物 (A)，该聚合物包含一种或多种由通式 (I)、(II) 或 (III) 表示的组成单元 (b) 和一种或多种可赋予生物降解性的其他组成单元 (a)： 其中，在式 (I) 中，R¹ 和 R 独立地为氢原子、氯原子、溴原子、甲基、乙基或苯基；在式 (II) 中，R³ 和 R⁴ 独立地为氢原子、氯原子、溴原子或取代或未取代的甲基或乙基；在式 (III) 中，R⁵ 和 R⁶ 独立地是氢原子、甲基或乙基，R⁷ 是直链、支链或环状烷基、芳基、杂环基或芳烷基，它们可以有一个或多个取代基。
• COMPOSITION FOR OPTICAL MATERIAL, OPTICAL MATERIAL, AND PLASTIC LENS
  申请人：NOF CORPORATION

  公开号：EP1331494A1

  公开（公告）日：2003-07-30

  Optical material compositions are disclosed having excellent castability, and provide, by curing, optical materials having excellent colorlessness, transparency, and weatherability, high refractive index, and superior impact resistance, heat resistance, and dyeability. The optical material composition contains a polymerizable component containing a diallyl compound, a benzotriazole ultraviolet absorber, a blue pigment, and a nonionic surfactant. Also disclosed are optical materials having a refractive index of not lower than 1.53, and an Abbe's number of not smaller than 33, and plastic lenses.

  本发明所公开的光学材料组合物具有优异的可浇铸性，通过固化可提供具有优异的无色性、透明度和耐候性、高折射率以及优异的抗冲击性、耐热性和染色性的光学材料。该光学材料组合物包含一种可聚合成分，其中含有二烯丙基化合物、苯并三唑紫外线吸收剂、蓝色颜料和非离子表面活性剂。还公开了折射率不低于 1.53、阿贝数不小于 33 的光学材料和塑料镜片。
• Fumaric acid derivates and ophtalmic lenses using the same
  申请人：E-brain Corporation Ltd.

  公开号：EP1930338A1

  公开（公告）日：2008-06-11

  The present invention relates to fumaric acid derivatives and ophthalmic lenses using them. More specifically, the present invention relates to a fumaric acid derivative having a hydrophilic group and a silicon-containing alkyl group within a molecule, and to contact lenses or intraocular lenses. The fumaric acid derivatives of the present invention provide, on one hand, superior oxygen permeability by having a silicon-containing alkyl group within the molecular structure, and on the other hand, improved compatibility with other hydrophilic monomers by having a hydrophilic group within the same molecule. When ophthalmic lenses obtained by polymerizing monomer compositions containing the fumaric acid derivative are constructed as, for example, water content lenses, lenses with high oxygen permeability independent from the water content may be obtained, wherein the fumaric acid derivatives is superior in compatibility with the hydrophilic monomer used in combination and allows the combination in various mixing ratios.

  本发明涉及富马酸衍生物和使用富马酸衍生物的眼科镜片。更具体地说，本发明涉及一种在分子中具有亲水基团和含硅烷基的富马酸衍生物，以及隐形眼镜或眼内镜。 本发明的富马酸衍生物一方面通过在分子结构中含有含硅烷基来提供优异的透氧性，另一方面通过在同一分子中含有亲水基团来改善与其他亲水单体的兼容性。当通过聚合含有富马酸衍生物的单体组合物而获得的眼科镜片被制造成例如含水量镜片时，可获得与含水量无关的高透氧性镜片，其中富马酸衍生物与亲水单体组合物的相容性更好，并允许以各种混合比例进行组合。
• LIQUID CRYSTAL LIGHT CONTROL ELEMENT AND PROCESS FOR PRODUCING THE LIQUID CRYSTAL LIGHT CONTROL ELEMENT
  申请人：Nippon Sheet Glass Company Limited

  公开号：EP2224279A1

  公开（公告）日：2010-09-01

  In the production method of the present invention, an emulsion including a copolymer with a glass transition temperature (Tg) of -50 to 20°C is obtained by the emulsion polymerization of a monomer group including a monomer A that is a (meth)acrylic acid alkyl ester (where the alkyl group is an open chain group with 1 to 20 carbon atoms or a cyclic group with 5 to 20 carbon atoms) as the main monomer and a monomer B having a carbon-carbon double bond and a nonionic hydrophilic group such as a polyoxyalkylene group, an amide group, and a hydroxyl group. Liquid crystals are dispersed in this emulsion, which is applied onto a conductive film-coated substrate. Another conductive film-coated substrate is laminated thereto, and thus a liquid crystal light control device is obtained. A monomer C having a carboxyl group and/or an amino group and a carbon-carbon double bond may be used in combination with a crosslinking agent so that a crosslinked structure is introduced into the copolymer. The present invention provides a liquid crystal light control device in which the transparency with a voltage applied and the shielding property with no voltage applied are compatible at high level.

  在本发明的生产方法中一种包括玻璃化转变温度（Tg）为 -50 至 20°C 的共聚物的乳液，是由包括作为主单体的（甲基）丙烯酸烷基酯（其中烷基是具有 1 至 20 个碳原子的开链基团或具有 5 至 20 个碳原子的环状基团）的单体 A 和具有碳碳双键和非离子亲水基团（如聚氧烷基、酰胺基和羟基）的单体 B 的乳液聚合而成。液晶分散在这种乳液中，然后涂在涂有导电薄膜的基底上。将另一种涂有导电薄膜的基底层压在上面，就得到了液晶光控制装置。具有羧基和/或氨基以及碳碳双键的单体 C 可与交联剂结合使用，从而在共聚物中引入交联结构。本发明提供了一种液晶光控制装置，在该装置中，加电压时的透明性和不加电压时的屏蔽性在高水平上兼容。