n-eicosanoic acid ethenyl ester | 5899-18-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: n-eicosanoic acid ethenyl ester
• 英文别名: eicosanoic acid ethenyl ester；arachidic acid ethenyl ester；vinyl arachidate；Ethenyl icosanoate
• CAS: 5899-18-3
• 化学式: C₂₂H₄₂O₂
• 分子量: 338.574
• InChiKey: LTDFJOPAUCPEEN-UHFFFAOYSA-N

物化性质

• 沸点：
  414.1±14.0 °C(Predicted)
• 密度：
  0.867±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  24
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  n-eicosanoic acid ethenyl ester 、 (-)-表没食子儿茶素没食子酸酯 在 Lipase PL from Alcaligenes sp. 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.5h， 生成 (2R,3R)-2-(3,4-dihydroxy-5-(icosanoyloxy)phenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate 、 (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,5-dihydroxy-4-(icosanoyloxy)benzoate 、 (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4-dihydroxy-5-(icosanoyloxy)benzoate 、 (2R,3R)-2-(3,5-dihydroxy-4-(icosanoyloxy)phenyl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate
  参考文献：
  名称：

  Enhanced anti-influenza A virus activity of (−)-epigallocatechin-3-O-gallate fatty acid monoester derivatives: Effect of alkyl chain length

  摘要：

  A series of fatty acid monoester derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) were prepared by one-pot lipase-catalyzed transesterification. The introduction of long alkyl chains enhanced anti-influenza A/PR8/34 (H1N1) virus activity 24-fold relative to native EGCG. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.020

文献信息

• MEMBRANE FUSION INHIBITOR
  申请人：Kaihatsu Kunihiro

  公开号：US20110003889A1

  公开（公告）日：2011-01-06

  The present invention provides a pharmaceutical composition that has excellent safety and targets a different step in the virus propagation cycle than conventional pharmaceutical compositions, applicable as an antiviral agent. A pharmaceutical composition containing an epigallocatechin gallate derivative represented by the following chemical formula (1), an isomer thereof, or a salt thereof is prepared. This can be used as a membrane fusion inhibitor that inhibits viral membrane fusion. In the following formula, R 1 to R 6 are each a hydrogen atom, halogen, sodium, potassium, or a straight-chain or branched, saturated or unsaturated acyl group and may be identical to or different from one another. The acyl group may be substituted further with one or more substituents. At least one of R 1 to R 6 is the acyl group. R 7 to R 16 are each a hydrogen atom, halogen, sodium, or potassium and may be identical to or different from one another.

  本发明提供了一种药物组合物，具有优异的安全性，并且针对病毒传播周期中不同的步骤，适用于抗病毒药剂。制备了一种含有以下化学式（1）所表示的表沙黄酮酸酯衍生物、其异构体或其盐的药物组合物。它可以用作抑制病毒膜融合的膜融合抑制剂。在下面的公式中，R1到R6分别是氢原子、卤素、钠、钾或直链或支链、饱和或不饱和的酰基，可以相同或不同。酰基还可以进一步取代一个或多个取代基。其中至少一个是酰基。R7到R16分别是氢原子、卤素、钠或钾，可以相同或不同。
• ANTIBACTERIAL AGENT
  申请人：Osaka University

  公开号：EP2460405A1

  公开（公告）日：2012-06-06

  The present invention provides an epigallocatechin gallate derivative (EGCG derivative) that has excellent safety and antibacterial properties. An epigallocatechin gallate derivative represented by the following chemical formula (1), an isomer thereof, or a salt thereof is used as an antibacterial agent. In the formula, R1 to R6 are each a hydrogen atom, halogen, sodium, potassium, or a straight-chain or branched, saturated or unsaturated acyl group and may be identical to or different from one another. The acyl group may be substituted further with one or more substituents. At least one of the R1 to R6 is the acyl group. R7 to R16 are each a hydrogen atom, halogen, sodium, or potassium and may be identical to or different from one another.

  本发明提供了一种具有极佳安全性和抗菌性的表没食子儿茶素没食子酸酯衍生物（EGCG 衍生物）。由以下化学式（1）表示的表没食子儿茶素没食子酸酯衍生物、其异构体或其盐可用作抗菌剂。式中，R1 至 R6 各为氢原子、卤素、钠、钾或直链或支链、饱和或不饱和酰基，可彼此相同或不同。酰基可进一步被一个或多个取代基取代。R1 至 R6 中至少有一个是酰基。R7 至 R16 各为氢原子、卤素、钠或钾，可彼此相同或不同。
• OIL-BASED INKJET INK SET AND METHOD FOR PRODUCING PRINTED ITEM
  申请人：Riso Kagaku Corporation

  公开号：EP3461868A2

  公开（公告）日：2019-04-03

  An oil-based inkjet ink set is disclosed that includes: an oil-based inkjet ink A containing a non-aqueous solvent, the non-aqueous solvent of the oil-based inkjet ink A containing at least 15% by mass of a silicone oil relative to the total mass of the non-aqueous solvent of the oil-based inkjet ink A, and an oil-based inkjet ink B containing a non-aqueous solvent, the non-aqueous solvent of the oil-based inkjet ink B containing at least 50% by mass of a petroleum-based hydrocarbon solvent relative to the total mass of the non-aqueous solvent of the oil-based inkjet ink B. A method for producing a printed item is also disclosed.

  本发明公开了一种油基喷墨墨水组，它包括含非水性溶剂的油基喷墨墨水 A，油基喷墨墨水 A 的非水性溶剂中硅油的质量占油基喷墨墨水 A 的非水性溶剂总质量的至少 15%、和含有非水溶剂的油基喷墨墨水 B，油基喷墨墨水 B 的非水溶剂含有相对于油基喷墨墨水 B 的非水溶剂总质量至少 50% 的石油基烃溶剂。还公开了一种生产印刷品的方法。
• Composition for inhibiting formation of SNARE complex, containing myricetin derivatives
  申请人：RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY

  公开号：US10682333B2

  公开（公告）日：2020-06-16

  The present invention relates to a composition for inhibiting the formation of a SNARE complex, containing myricetin derivatives, and having novel structures and obtained by the acylation of myricetin, laricitrin, combretol, or syringetin. The myricetin derivatives are considered to exhibit an effect of being bioconverted into myricetin in a cell. The myricetin derivatives lost the dark color of conventional myricetin and properties thereof were changed such that the myricetin derivatives have properties of photostability and fat solubility. Therefore, since stable form myricetin derivatives are absorbed into a cell such that an activity, possessed by normal myricetin, of inhibiting the formation of a SNARE complex are exhibited, the present invention can exhibit an excellent function as a SNARE targeting prodrug, and as a composition for inhibiting the formation of a SNARE complex, containing the same.

  本发明涉及一种抑制 SNARE 复合物形成的组合物，该组合物含有米果黄素衍生物，具有新颖的结构，由米果黄素、laricitrin、combretol 或 syringetin酰化获得。这些杨梅素衍生物被认为具有在细胞中生物转化为杨梅素的效果。这种杨梅素衍生物失去了传统杨梅素的深色，其性质也发生了变化，使杨梅素衍生物具有光稳定性和脂溶性。因此，由于稳定形式的水杨梅素衍生物可被细胞吸收，从而显示出普通水杨梅素所具有的抑制 SNARE 复合物形成的活性，因此本发明作为 SNARE 靶向原药和抑制 SNARE 复合物形成的组合物，可发挥出色的功能。
• Oil-based inkjet ink
  申请人：RISO KAGAKU CORPORATION

  公开号：US10717887B2

  公开（公告）日：2020-07-21

  An oil-based inkjet is disclosed, the oil-based inkjet ink containing a pigment, a pigment dispersant and a non-aqueous solvent, wherein the non-aqueous solvent contains a silicone oil having a surface tension of at least 19.0 mN/m but less than 24.0 mN/m and a polar solvent having a surface tension of at least 27.0 mN/m, and a surface tension of the ink is at least 23.0 mN/m but less than 27.0 mN/m.

  公开了一种油基喷墨，油基喷墨墨水含有颜料、颜料分散剂和非水溶剂，其中非水溶剂含有表面张力至少为 19.0 mN/m 但小于 24.0 mN/m 的硅油和表面张力至少为 27.0 mN/m 的极性溶剂，墨水的表面张力至少为 23.0 mN/m 但小于 27.0 mN/m。