9-ethoxy-7H-furo[3,2-g]chromen-7-one | 83934-65-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 9-ethoxy-7H-furo[3,2-g]chromen-7-one
• 英文别名: 8-ethoxypsoralen；9-ethoxy-furo[3,2-g]chromen-7-one；9-Aethoxy-furo[3,2-g]chromen-7-on；7H-Furo(3,2-g)(1)benzopyran-7-one, 9-ethoxy-；9-ethoxyfuro[3,2-g]chromen-7-one
• CAS: 83934-65-0
• 化学式: C₁₃H₁₀O₄
• 分子量: 230.22
• InChiKey: FDNAQBKTQHGTPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  48.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  9-ethoxy-7H-furo[3,2-g]chromen-7-one 生成 9-ethoxy-4-nitrofuro[3,2-g]chromen-7-one
  参考文献：
  名称：

  NOFAL, Z. M.;MANDOUR, A. H.;KUBACY, T.;MESHAAL, S. M., PAKISTAN J. SCI. AND IND. RES., 33,(1990) N, C. 148-150

  摘要：

  DOI：
• 作为产物：
  描述：

  8-甲氧基补骨脂素 在 三溴化硼 、 potassium carbonate 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 12.5h， 生成 9-ethoxy-7H-furo[3,2-g]chromen-7-one
  参考文献：
  名称：

  Deng, Xian-Qing; Wei, Cheng-Xi; Song, Ming-Xia, Arzneimittel-Forschung/Drug Research, 2010, vol. 60, # 10, p. 587 - 592

  摘要：

  DOI：

文献信息

• CHEMICAL CROSSLINKERS AND COMPOSITIONS THEREOF
  申请人：Nguyen Mark Quang

  公开号：US20140249319A1

  公开（公告）日：2014-09-04

  Chemical crosslinkers and methods of their synthesis are disclosed.

  化学交联剂及其合成方法已被披露。
• A simple one-step synthesis of phenyl ethers from phenyl acetates
  作者：Sunil K. Banerjee、Bishan D. Gupta、Kuber Singh

  DOI：10.1039/c39820000815

  日期：——

  Phenyl acetates when refluxed with alkyl halides in acetone solution in the presence of a crown ether and anhydrous potassium carbonate undergo alkylation yielding phenyl ethers.

  在冠醚和无水碳酸钾的存在下，乙酸苯酯与烷基卤在丙酮溶液中回流时，进行烷基化，生成苯基醚。
• CLEAVABLE DRUG CONJUGATES, COMPOSITIONS THEREOF AND METHODS OF USE
  申请人：NGUYEN MARK QUANG

  公开号：US20140294851A1

  公开（公告）日：2014-10-02

  Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.

  揭示了一种含有易碱性交联剂的易碱性共轭物、其合成和使用方法。
• Structural modification of a specific antimicrobial lead against Helicobacter pylori discovered from traditional Chinese medicine and a structure–activity relationship study
  作者：Bang-Le Zhang、Cheng-Qi Fan、Lei Dong、Fang-Dao Wang、Jian-Min Yue

  DOI：10.1016/j.ejmech.2010.08.045

  日期：2010.11

  Psoralen (1a) was found to be a specific and potent antimicrobial lead against Helicobacter pylori (H. pylori) from a traditional Chinese medicine (TCM) in the bioassay directed isolation. A series of structurally diverse analogues of la were thus designed and synthesized to improve the antimicrobial potency, some of which showed more potent activities than the lead compound (1a) against H. pylori. Among them, compound 25a is 16-fold stronger (MIC = 0.39 mu g/mL) than 1a (MIC = 6.25 mu g/mL), and is even potent than the positive control metronidazole (MIC = 0.50 mu g/mL). The in vitro antimicrobial activities against H. pylori of these structurally diverse analogues based on the scaffold of la have also led to an outline of structure-activity relationship. (C) 2010 Elsevier Masson SAS. All rights reserved.
• Experiments with Xanthotoxin and Imperatorin Obtained from the Fruits of Ammi majus (L.)
  作者：Alexander Schönberg、Aly Sina

  DOI：10.1021/ja01166a523

  日期：1950.10