strychnine nitrate | 66-32-0

• 物质功能分类: 原料药 - 神经系统用药 - 中枢兴奋药
• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 马钱子生物碱
• 英文名称: strychnine nitrate
• 英文别名: strychnine; nitrate；Strychnin; Nitrat；strychnidin-10-one mononitrate；Nitric acid; strychnos；4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one;nitric acid
• CAS: 66-32-0
• 化学式: C₂₁H₂₂N₂O₂*HNO₃
• 分子量: 397.431
• InChiKey: PCGVPMHGSJFFTI-UHFFFAOYSA-N

物化性质

• 熔点：
  295°C
• 沸点：
  520.88°C (rough estimate)
• 密度：
  1.6270
• 溶解度：
  氯仿（微溶）、甲醇（微溶）、水（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  1.74
• 重原子数：
  29
• 可旋转键数：
  0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  98.8
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 危险等级：
  6.1(a)
• 危险品标志：
  T+
• 安全说明：
  S22,S36/37/39,S45
• 危险类别码：
  R26/27/28
• WGK Germany：
  3
• RTECS号：
  WL2450000
• 包装等级：
  I
• 危险类别：
  6.1(a)
• 危险品运输编号：
  UN 1692 6.1/PG 1
• 储存条件：
  本品应密封存放在阴凉避光处。

SDS

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Section I.Chemical Product and Company Identification
Chemical Name Strychnine Nitrate
Portland OR
Synonym Strychnine nitrate salt
Chemical Formula C21H22N2O2•HNO3
66-32-0
CAS Number

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Section II. Composition and Information on Ingredients
Toxicology Data
Chemical Name CAS Number Percent (%) TLV/PEL
Strychnine Nitrate 66-32-0 Min. 99.0 (T) Not available. Rat LD50 (oral) 16mg/kg
Mouse LD50 (oral) 0.93mg/kg
Rabbit LD50 (intravenous)
0.25mg/kg

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Section III. Hazards Identification
Highly toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or
Acute Health Effects
death. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
CARCINOGENIC EFFECTS : Not available.
Chronic Health Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
Toxicity to the reproductive system: Not available. Repeated or prolonged exposure to the substance can produce target
organs damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an
accumulation in one or many human organs.

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Section IV. First Aid Measures
Eye Contact Check for and remove any contact lenses. DO NOT use an eye ointment. Flush eyes with running water for a minimum of 15
minutes, occasionally lifting the upper and lower eyelids. Seek medical attention.
Skin Contact If the chemical gets spilled on a clothed portion of the body, remove the contaminated clothes as quickly as possible,
protecting your own hands and body. Place the victim under a deluge shower. If the chemical touches the victim's exposed
skin, such as the hands: Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be
particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with an emollient. If irritation persists,
seek medical attention. Wash any contaminated clothing before reusing.
Inhalation If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
Ingestion INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive. SEEK IMMEDIATE MEDICAL ATTENTION in
case of ingestion of a radioactive material.

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Section V. Fire and Explosion Data
Not available.
Flammability Not available. Auto-Ignition
Not available.
Flash Points Not available. Flammable Limits
Combustion Products These products include toxic carbon oxides (CO,CO2), nitrogen oxides (NO, NO2).
Fire Hazards
No specific information is available regarding the flammability of this compound in the presence of various materials.
Explosion Hazards Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
No additional information is available regarding the risks of explosion.
Fire Fighting Media SMALL FIRE: Use DRY chemicals, CO2, water spray or foam.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
Strychnine Nitrate

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Section VI. Accidental Release Measures
Spill Cleanup Highly toxic material.
Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
Instructions
assistance on disposal.

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Section VII. Handling and Storage
HIGHLY TOXIC COMPOUND. Keep locked up. LIGHT SENSITIVE--store in a darkened cabinet or closet. Keep away from
Handling and Storage
heat and sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all
Information
equipment containing material. DO NOT ingest. DO NOT breathe dust. In case of insufficient ventilation, wear suitable
respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with
skin and eyes.
Always store away from incompatible compounds such as oxidizing agents, alkalis, alkali carbonates and bicarbonates,
benzoates, dichromates, bromides, iodides, tannic and picric acids, salicyclates, borax, gold chlorides, and piperazine.

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Section VIII. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
below the exposure limit.
Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator should be used to avoid
Personal Protection
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
Not available.
Exposure Limits

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Section IX. Physical and Chemical Properties
Physical state @ 20°C Solid. (Powder.) Solubility
Soluble in water, ethanol, chloroform,
glycerol.
Not available. Insoluble in ether.
Specific Gravity
Molecular Weight 397.43 Partition Coefficient Not available.
Boiling Point Not available. Vapor Pressure Not available.
Not available. Not available.
Melting Point Vapor Density
Refractive Index Not available. Volatility Not available.
Not available. Odorless.
Critical Temperature Odor
Not available. Not available.
Viscosity Taste

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Section X. Stability and Reactivity Data

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This material is stable if stored under proper conditions. (See Section VII for instructions)
Stability
Conditions of Instability LIGHT SENSITIVE.
Incompatibilities
Highly reactive with oxidizing agents, alkalis, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides,
tannic and picric acids, salicyclates, borax, gold chlorides, and piperazine. .

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Section XI. Toxicological Information
WL2450000
RTECS Number
Ingestion. Inhalation. Eye contact. Skin contact.
Routes of Exposure
Rat LD50 (oral) 16mg/kg
Toxicity Data
Mouse LD50 (oral) 0.93mg/kg
Rabbit LD50 (intravenous) 0.25mg/kg
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
Toxicity to the reproductive system: Not available. Repeated or prolonged exposure to the substance can produce target
organs damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an
accumulation in one or many human organs.
Highly toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or
Acute Toxic Effects
death. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
Continued on Next Page
Strychnine Nitrate

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Section XII. Ecological Information
Ecotoxicity Not available.
Not available.
Environmental Fate

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Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local or regional authorities. You may be able to dissolve or mix material with a
Waste Disposal
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state, and local regulations when disposing of this substance.

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Section XIV. Transport Information
DOT Classification DOT CLASS 6.1: Poisonous material.
PIN Number
Proper Shipping Name Strychnine salts.
I
Packing Group (PG)
DOT Pictograms

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Section XV. Other Regulatory Information and Pictograms
TSCA Chemical Inventory This product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS Classification WHMIS CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
(Canada)
EINECS Number (EEC) 200-627-1
EEC Risk Statements R26/27/28- Very toxic by inhalation, in contact with skin and if swallowed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

类别：有毒物质
毒性分级：剧毒
急性毒性：

• 大鼠 LD50：16.2 毫克/公斤
• 小鼠 LD50：0.93 毫克/公斤

可燃性危险特性：可燃；火场分解产生有毒的氮氧化物烟雾

储运特性：库房应保持低温、通风和干燥，并与食品原料分开存放

灭火剂：水、二氧化碳、干粉、砂土

反应信息

• 作为反应物：
  描述：

  strychnine nitrate 在 硫酸 作用下， 生成 2-Nitro-strychnin
  参考文献：
  名称：

  Loebisch; Schoop, Monatshefte fur Chemie, 1885, vol. 6, p. 851

  摘要：

  DOI：
• 作为产物：
  描述：

  生成 strychnine nitrate
  参考文献：
  名称：

  Delepine, M., Bulletin de la Societe Chimique de France, 1917, vol. 21, p. 165

  摘要：

  DOI：

文献信息

• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Ir: MVol., 5.18.3, page 126 - 127
  作者：

  DOI：——

  日期：——
• Vitali, Chemisches Zentralblatt, 1903, vol. 74, # II, p. 312
  作者：Vitali

  DOI：——

  日期：——
• Delepine, M., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1914, vol. 159, p. 240
  作者：Delepine, M.

  DOI：——

  日期：——
• Siddiqui; Basha, Journal of the Indian Chemical Society, 1944, vol. 21, p. 285,287
  作者：Siddiqui、Basha

  DOI：——

  日期：——
• Jaeger, M. F.; Thomas, W., Verslag van de Gewone Vergadering van de Afdeling Natuurkunde, Koninklijke Nederlandse Akademie van Wetenschappen, 1918, vol. 27, p. 83
  作者：Jaeger, M. F.、Thomas, W.

  DOI：——

  日期：——

表征谱图