N,N'-(1,4-phenylene)bisacrylamide | 61088-96-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-(1,4-phenylene)bisacrylamide
• 英文别名: N,N'-p-phenylenebisacrylamide；N-[4-(prop-2-enoylamino)phenyl]prop-2-enamide
• CAS: 61088-96-8
• 化学式: C₁₂H₁₂N₂O₂
• 分子量: 216.239
• InChiKey: YSGITULMFHYMSG-UHFFFAOYSA-N

物化性质

• 沸点：
  480.2±41.0 °C(Predicted)
• 密度：
  1.209±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丙烯酰氯 、 对苯二胺 以 丙酮 为溶剂， 以87%的产率得到N,N'-(1,4-phenylene)bisacrylamide
  参考文献：
  名称：

  [EN] NEUTRALIZING VENOMOUS BIOMACROMOLECULES
  [FR] NEUTRALISATION DE BIOMACROMOLÉCULES DE VENIN

  摘要：

  本发明涉及包括无生物合成聚合物纳米粒子（NPs）的组合物和方法，其具有亲和力和特异性，可用于肽毒素、酶、信号蛋白和其他大型生物大分子。由于对磷脂酶攻击不敏感，合成聚合物NPs是当前技术的改进。在一种实施例中，所述组合物和方法涉及具有亲和力和特异性的合成聚合物NPs，用于三指毒素（3FTX）和磷脂酶A2。在一种实施例中，所述组合物和方法可用于延迟或预防因蛇咬而导致的组织坏死。

  公开号：

  WO2018112313A1

文献信息

• MOLECULARLY IMPRINTED POLYMERS
  申请人：Hearn Milton T. W.

  公开号：US20120052757A1

  公开（公告）日：2012-03-01

  The present invention provides methods of designing molecularly imprinted polymers (MIPs) which have applications in extracting bioactive compounds from a range of bioprocessing feedstocks and wastes. The present invention is further directed to MIPs designed by the methods of the present invention.

  本发明提供了设计分子印迹聚合物（MIPs）的方法，这些方法在从各种生物加工原料和废弃物中提取生物活性化合物方面具有应用。本发明进一步针对由本发明方法设计的MIPs。
• METHOD FOR PRODUCING A RADIOACTIVE TRACER
  申请人：Perollier Céline

  公开号：US20130053607A1

  公开（公告）日：2013-02-28

  A method for preparing a radioactive tracer provided with a radioactive fluorine isotope, including providing a precursor of the radioactive tracer, comprising at least one leaving group completely or partially formed by a labelling entity, wherein said leaving group can be moved by a fluoride ion, providing a molecularly imprinted polymer dedicated to the molecular recognition of at least the aforementioned labelling entity, exposing the precursor to a radioactive fluoride ion source under conditions suitable for movement of the leaving group by a radioactive fluoride ion, placing the mixture resulting from step (iii) in contact with the molecularly imprinted polymer under conditions suitable for the recognition of the labelling entity, and obtaining a solution containing the radioactive tracer provided with a radioactive isotope of fluorine obtained at the end of step (iii).

  一种制备具有放射性氟同位素的放射性示踪剂的方法，包括提供放射性示踪剂的前体，包括至少一个由标记实体完全或部分形成的离去基团，其中所述离去基团可以被氟离子移动，提供专门用于分子识别至少上述标记实体的分子印迹聚合物，将前体置于适宜于通过放射性氟离子移动离去基团的条件下的放射性氟离子源中，将步骤（iii）产生的混合物与分子印迹聚合物接触，在适宜于识别标记实体的条件下，获得含有放射性氟同位素的放射性示踪剂的溶液，该溶液是在步骤（iii）结束时获得的。
• KIT USEFUL FOR DETECTING, SEPARATING AND/OR CHARACTERIZING A MOLECULE OF INTEREST
  申请人：Le Foll Alexandra

  公开号：US20110263446A1

  公开（公告）日：2011-10-27

  A kit for separating and/or characterizing at least one molecule A of interest, the kit including: (i) a compound having the general formula: B—(R) n —Z in which: B represents a hydrogen atom or a detectable labeling entity; R represents a C 1 -C 10000 hydrocarbon unit which may be polymeric or non-polymeric and optionally incorporates one or more heteroatoms, chosen from N, O, S, Br, Cl, F, P, B, Si and/or one or more metals; n represents 0 or 1, with n being equal to 1 when B represents a hydrogen atom; and Z represents a functional group capable of reacting in a click chemistry reaction in order to form a linking function L click ; and (ii) a molecularly imprinted polymer dedicated to the molecular recognition of at least said linking function L click .

  一个用于分离和/或表征至少一种感兴趣的分子A的试剂盒，该试剂盒包括：(i) 具有一般公式的化合物：B—(R)n—Z，其中：B代表氢原子或可检测的标记实体；R代表C1-C10000碳氢化合物单元，可以是聚合物或非聚合物，并且可以选择性地包含一个或多个异原子，选自N、O、S、Br、Cl、F、P、B、Si和/或一个或多个金属；n表示0或1，当B代表氢原子时，n等于1；Z代表能够在点击化学反应中发生反应以形成连接功能Lclick的官能团；以及(ii) 专门用于分子识别至少所述连接功能Lclick的分子印迹聚合物。
• MOLECULARLY IMPRINTED POLYMERS FOR THE RECOGNITION OF GLUTATHIONE GSH, METHODS FOR PREPARING SAME AND USES THEREOF
  申请人：Perollier Celine

  公开号：US20100234565A1

  公开（公告）日：2010-09-16

  The present invention relates to new molecularly imprinted polymers which are suitable for the selective recognition of glutathione GSH and/or of an analog thereof, and in particular which are of use for the treatment of media comprising in particular a mixture of glutathione GSH, and/or of an analog thereof, with GSH adducts.

  本发明涉及新的分子印迹聚合物，适用于选择性识别谷胱甘肽GSH和/或其类似物，特别是用于处理包括谷胱甘肽GSH和/或其类似物与GSH加合物的介质。
• Polymer-supported reagent for the preparation of disulfide-bridged peptides
  申请人：Darlak Krzysztof

  公开号：US20060047105A1

  公开（公告）日：2006-03-02

  A reagent for preparation of disulfide-bridged peptides is provided that comprises an oxidative functionality bound to a cross-linked ethoxylate acrylate resin polymer. The reagent has the formula: wherein circle around (R)} is a cross-linked ethoxylate acrylate resin polymer. Methods of making and using this reagent are also described herein.

  提供了一种用于制备二硫键肽的试剂，其包括结合在交联乙氧基丙烯酸酯树脂聚合物上的氧化官能团。该试剂的化学式为：其中圆圈R}是交联乙氧基丙烯酸酯树脂聚合物。本文还描述了制备和使用该试剂的方法。