(5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-triethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-3-one | 361336-13-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-triethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-3-one
• 英文别名: (5S,8R,9S,10S,13S,14S,17S)-10,13-dimethyl-17-triethylsilyloxy-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one
• CAS: 361336-13-2
• 化学式: C₂₅H₄₄O₂Si
• 分子量: 404.709
• InChiKey: IWGUDAQNNSGYCI-NMTVEPIMSA-N

物化性质

• 沸点：
  455.5±38.0 °C(Predicted)
• 密度：
  0.99±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.99
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-triethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-3-one 在 polymer-bound NMe₃⁽¹⁺⁾*F^(1-) 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以90%的产率得到雄诺龙
  参考文献：
  名称：

  PASSflow Syntheses Using Functionalized Monolithic Polymer/Glass Composites in Flow-Through Microreactors Part of these studies were supported by the Fonds der Chemischen Industrie and the European Community (EC project number HPRI-CT-1999-00085) for which we are grateful. PASSflow=Polymer Assisted Solution-Phase Synthesis technique in flow-through mode.

  摘要：

  A chemistapos;s wish finally becomes reality: microreactors for every synthetic laboratory! By precipitation polymerization various polymers are introduced into the irregular pore system of a porous glass rod. By embedding these rods into a housing, followed by functionalization and immobilization of reagents onto the polymer phase, versatile microreactors are obtained. With this apparatus, chemical transformations in solution can be performed, for example, a steroid derivatization.

  DOI：

  10.1002/1521-3773(20011105)40:21<3995::aid-anie3995>3.0.co;2-v
• 作为产物：
  描述：

  (3S,5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-triethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-3-ol 在 2,2,6,6-tetramethyl-piperidine-N-oxyl 、 polymer-bound NMe₃⁽¹⁺⁾*Br(OAc)2^(1-) 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以100%的产率得到(5S,8R,9S,10S,13S,14S,17S)-10,13-Dimethyl-17-triethylsilanyloxy-hexadecahydro-cyclopenta[a]phenanthren-3-one
  参考文献：
  名称：

  PASSflow Syntheses Using Functionalized Monolithic Polymer/Glass Composites in Flow-Through Microreactors Part of these studies were supported by the Fonds der Chemischen Industrie and the European Community (EC project number HPRI-CT-1999-00085) for which we are grateful. PASSflow=Polymer Assisted Solution-Phase Synthesis technique in flow-through mode.

  摘要：

  A chemistapos;s wish finally becomes reality: microreactors for every synthetic laboratory! By precipitation polymerization various polymers are introduced into the irregular pore system of a porous glass rod. By embedding these rods into a housing, followed by functionalization and immobilization of reagents onto the polymer phase, versatile microreactors are obtained. With this apparatus, chemical transformations in solution can be performed, for example, a steroid derivatization.

  DOI：

  10.1002/1521-3773(20011105)40:21<3995::aid-anie3995>3.0.co;2-v

文献信息

• PASSflow Syntheses Using Functionalized Monolithic Polymer/Glass Composites in Flow-Through Microreactors Part of these studies were supported by the Fonds der Chemischen Industrie and the European Community (EC project number HPRI-CT-1999-00085) for which we are grateful. PASSflow=Polymer Assisted Solution-Phase Synthesis technique in flow-through mode.
  作者：Andreas Kirschning、Carsten Altwicker、Gerald Dräger、Jan Harders、Nora Hoffmann、Ulrich Hoffmann、Hagen Schönfeld、Wladimir Solodenko、Ulrich Kunz

  DOI：10.1002/1521-3773(20011105)40:21<3995::aid-anie3995>3.0.co;2-v

  日期：2001.11.5

  A chemistapos;s wish finally becomes reality: microreactors for every synthetic laboratory! By precipitation polymerization various polymers are introduced into the irregular pore system of a porous glass rod. By embedding these rods into a housing, followed by functionalization and immobilization of reagents onto the polymer phase, versatile microreactors are obtained. With this apparatus, chemical transformations in solution can be performed, for example, a steroid derivatization.