α-p-Ethoxyanilino-benzylcyanid | 32323-75-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: α-p-Ethoxyanilino-benzylcyanid
• 英文别名: p-phenetidino-phenyl-acetonitrile；α-p-Phenetidino-phenylessigsaeure-nitril；(α-Cyan-benzyl)-p-phenetidin；2-(4-Ethoxyanilino)-2-phenylacetonitrile
• CAS: 32323-75-4
• 化学式: C₁₆H₁₆N₂O
• 分子量: 252.316
• InChiKey: CUWGZVDGYWLPJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  45
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  α-p-Ethoxyanilino-benzylcyanid 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以88%的产率得到(4-Ethoxy-phenylamino)-phenyl-acetic acid; hydrochloride
  参考文献：
  名称：

  Naim, S. Shawkat; Khan, Naseem H.; Siddiqui, Amin A., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 7, p. 622 - 624

  摘要：

  DOI：
• 作为产物：
  描述：

  N-benzylidene-4-ethoxyaniline 、 氰化钾 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 以93%的产率得到α-p-Ethoxyanilino-benzylcyanid
  参考文献：
  名称：

  Naim, S. Shawkat; Khan, Naseem H.; Siddiqui, Amin A., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1980, vol. 19, # 7, p. 622 - 624

  摘要：

  DOI：

文献信息

• Cycloaddition Reactions of N-Sulphdvylanilines and N-(αCyano-α-aryl)-Methylanilines
  作者：Kewal Krishan Singal、Baldev Singh、Baldev Raj

  DOI：10.1080/00397919908086052

  日期：1999.3

  Abstract Through the cycloaddition of N-(α-cyano-α-aryl)-methylanilines (II) on to N-sulphinylanilines (III) are synthesized 2,3,5-triaryl-4-imino-2H, 3H, 5H-[1.2.5]thiadiazoIidin-l-oxides (TV) in aood vields.

  摘要 通过 N-(α-氰基-α-芳基)-甲基苯胺 (II) 与 N-亚磺基苯胺 (III) 的环加成反应合成了 2,3,5-三芳基-4-亚氨基-2H, 3H, 5H-[ 1.2.5]aood 领域中的 thiadiazolidin-l-oxides (TV)。
• LAPAROSCOPIC NEPHROURETERECTOMY FOR UPPER TRACT TRANSITIONAL CELL CANCER: THE WASHINGTON UNIVERSITY EXPERIENCE
  作者：ARIEH L. SHALHAV、MATTHEW D. DUNN、ANDREW J. PORTIS、ABDELHAMID M. ELBAHNASY、ELSPETH M. M c DOUGALL、RALPH V. CLAYMAN

  DOI：10.1016/s0022-5347(05)67701-4

  日期：2000.4

  Purpose: Laparoscopic nephroureterectomy has only recently been done to treat patients with upper tract transitional cell carcinoma. We retrospectively evaluated our experience with and long-term followup of laparoscopic nephroureterectomy, compared our results to those of contemporary series of open nephroureterectomy and reviewed the literature.Materials and Methods: We reviewed the charts of and followed up by telephone 25 patients who underwent laparoscopic nephroureterectomy between May 1991 and June 1998, and 17 who underwent open nephroureterectomy between March 1990 and January 1997. Demographic, perioperative and followup data were compared. We performed a MEDLINE search and reviewed the literature on laparoscopic nephroureterectomy for upper tract transitional cell carcinoma.Results: Laparoscopic nephroureterectomy required twice the operating time of open nephroureterectomy (7.7 versus 3.9 hours). However, patients who underwent the laparoscopic procedure had a 74% decrease in analgesia requirements (37 versus 144 mg. morphine sulfate equivalent), a 63% shorter hospital stay (3.6 versus 9.6 days) and a 72% more rapid convalescence (2.8 versus 10 weeks). Subsequent bladder transitional cell carcinoma and overall cancer specific survival were similar at a mean followup of 2 years. There was no sign of trocar site or peritoneal seeding after laparoscopic nephroureterectomy.Conclusions: Although laparoscopic nephroureterectomy is a longer operation, it has the same efficacy and is better tolerated by patients than open nephroureterectomy for upper tract transitional cell carcinoma. As operating time decreases due to surgeon experience and the recent development of hand assisted laparoscopy, laparoscopic nephroureterectomy may soon become the procedure of choice for the ablative management of upper tract transitional cell carcinoma.