1-(Prop-2-enyl)-4,4-dimethyl-2,5-dioxoimidazolidine | 3366-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-(Prop-2-enyl)-4,4-dimethyl-2,5-dioxoimidazolidine
• 英文别名: 3-allyl-5,5-dimethylhydantoin；ADMH；3-allyl-5,5-dimethyl-imidazolidine-2,4-dione；5,5-dimethyl-3-(2-propenyl)-2,4-imidazolidinedione；1-(prop-2-enyl)-4,4dimethyl-2,5-dioxoimidazolidine；3-allyl-5,5-dimethylimidazolidine-2,4-dione；5,5-dimethyl-3-prop-2-enylimidazolidine-2,4-dione
• CAS: 3366-92-5
• 化学式: C₈H₁₂N₂O₂
• mdl: MFCD00181254
• 分子量: 168.195
• InChiKey: HOJYCNSTMZLRCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  1-(Prop-2-enyl)-4,4-dimethyl-2,5-dioxoimidazolidine 在 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 乙酸乙酯 为溶剂， 生成 (+/-)-1-((1',2'-oxiranyl)propyl)-3,4,4-trimethyl-2,5-dioxoimidazolidine
  参考文献：
  名称：

  Reverse hydroxamate inhibitors of matrix metalloproteinases

  摘要：

  具有该公式的化合物是基质金属蛋白酶抑制剂。还公开了基质金属蛋白酶抑制组合物和在哺乳动物中抑制基质金属蛋白酶的方法。

  公开号：

  US06235786B1
• 作为产物：
  描述：

  5,5-二甲基海因 以 N-甲基乙酰胺 为溶剂， 生成 1-(Prop-2-enyl)-4,4-dimethyl-2,5-dioxoimidazolidine
  参考文献：
  名称：

  Vinyl ethers, process for their preparation, and their use for the

  摘要：

  本发明涉及新的咪唑烷基乙烯醚，其化学式为##STR1##其中R.sub.1是氢或有机基团，R.sub.2是烷基基团，R.sub.3和R.sub.4最好是较低的烷基基团。这些化合物用于制备均聚物和共聚物，可用作增稠剂、增溶剂、粘合剂、流变剂、络合剂、稳定剂等。

  公开号：

  US04206309A1

文献信息

• Heteroaryl-substituted amides comprising an unsaturated or cyclic linker group, and their use as pharmaceuticals
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：EP1741708A1

  公开（公告）日：2007-01-10

  The present invention relates to N-alkylamides of the formula I, in which A, Het, X, R1, R2 and R3 have the meanings indicated in the claims, which modulate the transcription of endothelial nitric oxide (NO) synthase and are valuable pharmacologically active compounds. Specifically, the compounds of the formula I upregulate the expression of the enzyme endothelial NO synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention further relates to processes for the preparation of compounds of the formula I, to pharmaceutical compositions comprising them, and to the use of compounds of the formula I for the manufacture of a medicament for the stimulation of the expression of endothelial NO synthase or for the treatment of various diseases including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency, for example.

  本发明涉及公式I的N-烷基酰胺， 其中A、Het、X、R1、R2和R3具有权利要求中所指示的含义，这些化合物调节内皮型一氧化氮（NO）合酶的转录，并且是有价值的药理活性化合物。具体地，公式I的化合物上调内皮型一氧化氮合酶的表达，并可应用于需要增加该酶的表达或增加NO水平或恢复降低的NO水平的情况。本发明还涉及制备公式I化合物的方法，包括它们的药物组合物，以及利用公式I化合物制造用于刺激内皮型一氧化氮合酶表达或治疗各种疾病的药物，包括心血管疾病，如动脉粥样硬化、血栓形成、冠状动脉疾病、高血压和心脏功能不全等。
• Poly(ethylene glycol)s as grinding additives in the mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins
  作者：Andrea Mascitti、Massimiliano Lupacchini、Ruben Guerra、Ilya Taydakov、Lucia Tonucci、Nicola d’Alessandro、Frederic Lamaty、Jean Martinez、Evelina Colacino

  DOI：10.3762/bjoc.13.3

  日期：——

  The mechanochemical preparation of highly functionalized 3,5-disubstituted hydantoins was investigated in the presence of various poly(ethylene) glycols (PEGs), as safe grinding assisting agents (liquid-assisted grinding, LAG). A comparative study under dry-grinding conditions was also performed. The results showed that the cyclization reaction was influenced by the amount of the PEG grinding agents

  在作为安全研磨助剂（液体辅助研磨，LAG）的各种聚乙二醇（PEG）存在下，研究了高度官能化的3,5-二取代乙内酰脲的机械化学制备。还进行了干磨条件下的比较研究。结果表明，环化反应受PEG研磨剂的量影响。通常，与干研磨程序相比，在PEG存在下观察到更干净的反应曲线。
• N-halamine vinyl compounds and their polymeric biocides
  申请人：Regents of the University of California

  公开号：US20030216581A1

  公开（公告）日：2003-11-20

  The present invention provides heterocyclic vinylic compounds that can be used to form biocidal polymers. The polymers thus generated can used alone or can be grafted onto textiles, fabrics and polymers. The polymers are readily converted to N-halamine structures on exposure to a halogen source such as commercially available chlorine bleach. The N-halamine derivatives exhibit potent antibacterial properties against microorganisms and these properties are durable and regenerable.

  本发明提供了可以用于形成生物杀菌聚合物的杂环乙烯化合物。因此生成的聚合物可以单独使用或嫁接到纺织品、织物和聚合物上。这些聚合物在暴露于卤素源（如商业氯漂白剂）时可以很容易地转化为N-卤胺结构。N-卤胺衍生物对微生物具有强大的抗菌性能，这些性能耐久且可再生。
• [EN] FUNCTIONALIZED MATERIALS AND COMPOUNDS<br/>[FR] MATÉRIAUX ET COMPOSÉS FONCTIONNALISÉS
  申请人：UNIV SOUTH ALABAMA

  公开号：WO2020086938A1

  公开（公告）日：2020-04-30

  Processes for chemical functionalization of materials is described. The processed generally include chemical reaction between a thiol group of a first compound or material and an alkane group or alkyne group of a second compound or material. Also disclosed are functionalized materials and compounds suitable for functionalizing a material.

  描述了材料的化学功能化过程。通常包括第一化合物或材料的硫醇基团与第二化合物或材料的烷基或炔基之间的化学反应。还披露了适用于功能化材料的功能化材料和化合物。
• Unsaturated hydantoin coagents
  申请人：Ciba-Geigy Corporation

  公开号：US04091223A1

  公开（公告）日：1978-05-23

  Unsaturated hydantoin derivatives of the formula ##STR1## WHERE R.sub.1 and R.sub.2 are alkyl, R.sub.3 is vinyl, allyl, alkylene, substituted alkylene or polyvalent aralkyl, R.sub.4 is vinyl or allyl and n is 1 to 3, are coagents for curing polymeric compositions to improve their physical, chemical and electrical properties. These coagents are particularly useful in crosslinking PVC, polyethylene, chlorinated polyethylene and poly(ethylene/vinyl acetate) compositions.

  式为##STR1##其中R.sub.1和R.sub.2为烷基，R.sub.3为乙烯基、丙烯基、烷基、取代烷基或多价芳基烷基，R.sub.4为乙烯基或丙烯基，n为1至3的不饱和咪唑啉衍生物，是固化聚合物组合物的协同剂，以提高其物理、化学和电学性能。这些协同剂在交联PVC、聚乙烯、氯化聚乙烯和聚（乙烯/醋酸乙烯）组合物中特别有用。

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