methyl 2-methyl-1-phenylaziridine-2-carboxylate | 4916-07-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-methyl-1-phenylaziridine-2-carboxylate
• CAS: 4916-07-8
• 化学式: C₁₁H₁₃NO₂
• 分子量: 191.23
• InChiKey: OYXBSBWAYPBUDH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲基丙烯酸甲酯 以 乙醚 为溶剂， 25.0 ℃ 、1200.0 MPa 条件下， 反应 192.0h， 生成 methyl 2-methyl-1-phenylaziridine-2-carboxylate
  参考文献：
  名称：

  High-pressure induced 1,3-dipolar cycloadditions of azides with electron-deficient olefins

  摘要：

  DOI：

  10.1021/jo00024a047

文献信息

• [EN] AZIRIDINE SYNTHESIS<br/>[FR] SYNTHÈSE D'AZIRIDINE
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2009096907A1

  公开（公告）日：2009-08-06

  The invention relates to a process for making an aziridine, wherein an aldehyde, a nitroso compound and a Michael acceptor are reacted in the presence of an N-heterocyclic carbene (NHC) catalyst.

  该发明涉及一种制备环氮丙烷的方法，其中在N-杂环卡宾（NHC）催化剂的存在下，醛、亚硝基化合物和迈克尔受体发生反应。
• N-Heterocyclic Carbene (NHC)-Catalyzed Direct Amidation of Aldehydes with Nitroso Compounds
  作者：Fong Tian Wong、Pranab K. Patra、Jayasree Seayad、Yugen Zhang、Jackie Y. Ying

  DOI：10.1021/ol8004276

  日期：2008.6.1

  NHC-catalyzed direct amidation of aldehydes with nitroso compounds is a powerful method for the synthesis of N-arylhydroxamic acids. A variety of aryl, alkyl, alkenyl, and heterocyclic aldehydes were found to give excellent yields of the corresponding N-arylhydroxamic acids. This chemistry was also extended to the synthesis of chiral N-arylhydroxamic acids by kinetic resolution of a-branched aldehydes, a domino amidation-redox amination reaction of acrolein, and a three-component reaction for the synthesis of N-arylaziridines.
• AZIRIDINE SYNTHESIS
  申请人：Patra Pranab K.

  公开号：US20110112310A1

  公开（公告）日：2011-05-12

  The invention relates to a process for making an aziridine. wherein an aldehyde, a nitroso compound and a Michael acceptor are reacted in the presence of an N-heterocyclic carbene (NHC) catalyst.