2,4-Diethyl-2,7,8-trimethyl-2,3-dihydro-1H-1,5-benzodiazepine | 434339-61-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 2,4-Diethyl-2,7,8-trimethyl-2,3-dihydro-1H-1,5-benzodiazepine
• 英文别名: 2,4-diethyl-2,7,8-trimethyl-1,3-dihydro-1,5-benzodiazepine
• CAS: 434339-61-4
• 化学式: C₁₆H₂₄N₂
• 分子量: 244.38
• InChiKey: ZVOMNVZBJDJHBF-UHFFFAOYSA-N

物化性质

• 熔点：
  141 °C
• 沸点：
  371.7±42.0 °C(Predicted)
• 密度：
  1.00±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4，5-二甲基-1，2-苯二胺 、 丁酮 在 cerium(III) chloride 、 sodium iodide silica gel 作用下， 反应 0.83h， 以92%的产率得到2,4-Diethyl-2,7,8-trimethyl-2,3-dihydro-1H-1,5-benzodiazepine
  参考文献：
  名称：

  硅胶上负载的氯化铈（III）/碘化钠用于合成1,5-苯二氮卓类化合物的一种新的，高效且环保的方案†

  摘要：

  已经描述了一种新颖的绿色方法，该方法使用负载在硅胶上的氯化铈（III）/碘化钠在温和和非均相条件下，由邻苯二胺和酮合成2，3-二氢-1 H -1,5-苯并二氮杂卓。反应在室温下进行，无需使用任何有机溶剂。

  DOI：

  10.1002/adsc.200303196

文献信息

• Chitosan-supported Fe3O4 nanoparticles: a magnetically recyclable heterogeneous nanocatalyst for the syntheses of multifunctional benzimidazoles and benzodiazepines
  作者：Ali Maleki、Nakisa Ghamari、Maryam Kamalzare

  DOI：10.1039/c3ra47366j

  日期：——

  An environmentally benign and clean biopolymer-based heterogeneous nanocatalyst was prepared and its properties and morphology were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and X-ray diffraction (XRD). Then, its catalytic activity was investigated in two important organic reactions. In these reactions, efficient and selective syntheses of 1,2-disubstituted benzimidazole and 1,5-benzodiazepine derivatives were carried out using 1,2-diamines and aldehydes or ketones in the presence of a catalytic amount of magnetically recoverable chitosan-supported iron oxide nanoparticles (Fe3O4/chitosan), as a biodegradable nanocomposite, in ethanol at ambient temperature in high yields. The Fe3O4/chitosan nanocatalyst can be recovered easily and reused without any significant loss of the catalytic activity.

  制备了一种环境友好且清洁的生物聚合物基异质纳米催化剂，并通过扫描电子显微镜（SEM）、能量色散X射线光谱（EDX）和X射线衍射（XRD）对其性质和形态进行了表征。随后，研究了其在两种重要有机反应中的催化活性。在这些反应中，使用1,2-二胺和醛或酮在催化量的可磁回收壳聚糖支持铁氧化物纳米颗粒（Fe3O4/壳聚糖）的存在下，在室温下的乙醇中高效且选择性地合成了1,2-取代的苯并咪唑和1,5-苯并二氮杂卓衍生物。Fe3O4/壳聚糖纳米催化剂可以轻松回收并重复使用，且没有显著的催化活性损失。
• An efficient method for the synthesis of 1,5-benzodiazepine derivatives under microwave irradiation without solvent
  作者：Minothora Pozarentzi、Julia Stephanidou-Stephanatou、Constantinos A Tsoleridis

  DOI：10.1016/s0040-4039(02)00115-6

  日期：2002.2

  synthesized in solvent-free conditions from o-phenylenediamines and ketones in the presence of a catalytic amount of acetic acid, under microwave irradiation. This method is a very easy, rapid and high yielding reaction for the synthesis of 1,5-benzodiazepine derivatives.

  在无溶剂条件下，在微波辐射下，在催化量的乙酸存在下，由邻苯二胺和酮合成了2,3-二氢-1 H -1,5-苯并二氮杂s。该方法是合成1，5-苯并二氮杂pine衍生物的非常容易，快速和高产率的反应。
• Aluminum Dodecatungstophosphate Promoted Synthesis of 1,5-Benzodiazepine Derivatives under Solvent-Free Conditions
  作者：Razieh Fazaeli、Hamid Aliyan、Shahram Tangestaninejad

  DOI：10.3987/com-06-10948

  日期：——

  Solid heteropoly acids (A1TP and A1MP) are easily used as efficient catalyst for conversion of o-phenylenediamines and ketones to their corresponding 2,3-dihydro-1H-1,5-benzodiazepines at room temperature under solvent-free conditions. The method is an easy, rapid, and high yielding reaction for the synthesis of 1,5-benzodiazepine derivatives and is applicable to both cyclic or acyclic ketones without significant difference.
• An efficient synthesis of 1,5-benzodiazepine derivatives catalyzed by a solid superacid sulfated zirconia
  作者：Benjaram M. Reddy、Pavani M. Sreekanth

  DOI：10.1016/s0040-4039(03)01034-7

  日期：2003.6

  2.3-Dihydro-1H-1.5-benzodiazepiiies are synthesized by the condensation of o-phenylendiamine and various ketones in the presence of a versatile solid superacid catalyst 'sulfated zirconia' under solvent free conditions. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Kumar, S. Ramesh; Venkateshwarulu; Leelavathi, Asian Journal of Chemistry, 2011, vol. 23, # 4, p. 1611 - 1614
  作者：Kumar, S. Ramesh、Venkateshwarulu、Leelavathi

  DOI：——

  日期：——