1-(1,1-Dimethylethyl) (2R)-2-(aminomethyl)propanedioate | 348081-49-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-(1,1-Dimethylethyl) (2R)-2-(aminomethyl)propanedioate
• 英文别名: (2R)-2-(aminomethyl)-3-[(2-methylpropan-2-yl)oxy]-3-oxopropanoic acid
• CAS: 348081-49-2
• 化学式: C₈H₁₅NO₄
• 分子量: 189.21
• InChiKey: OWTIJNGQRFCGIO-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• (Hetero) Bicyclymethanesulfonylamino-substituted hydroxamic acid derivatives
  申请人：——

  公开号：US20030199571A1

  公开（公告）日：2003-10-23

  Compounds of formula (I) wherein R is hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R 1 is bicyclyl or heterobicyclyl; are useful in the treatment and prophylaxis of conditions mediated by s-CD23 or TNF.

  式（I）中的化合物，其中R是氢，烷基烯基，炔基，芳基，杂芳基或杂环烷基；R1是双环烷基或杂双环烷基；在通过s-CD23或TNF介导的疾病的治疗和预防中是有用的。
• (Hetero) bicyclymethanesulfonylamino-substituted hydroxamic acid derivates
  申请人：SmithKline Beecham p.l.c.

  公开号：US20040225006A1

  公开（公告）日：2004-11-11

  Compounds of formula (I) wherein R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R 1 is bicyclyl or heterobicyclyl; are useful in the treatment and prophylaxis of conditions mediated by s-CD23 or TNF. 1

  式(I)的化合物中，其中R为氢、烷基、烯基、炔基、芳基、杂芳基或杂环基；而R1为双环烷基或杂双环烷基；可用于治疗和预防由s-CD23或TNF.1介导的疾病。
• (HETERO)BICYCLYLMETHANESULFONYLAMINO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES
  申请人：SmithKline Beecham plc

  公开号：EP1244616A1

  公开（公告）日：2002-10-02
• [EN] (HETERO)BICYCLYMETHANESULFONYLAMINO-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES<br/>[FR] NOUVEAUX COMPOSES ET PROCESSUS
  申请人：SMITHKLINE BEECHAM PLC

  公开号：WO2001047874A1

  公开（公告）日：2001-07-05

  Compounds of formula (I) wherein R is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl or heterocyclyl; and R1 is bicyclyl or heterobicyclyl; are useful in the treatment and prophylaxis of conditions mediated by s-CD23 or TNF.