3,7-Dimethyl-7-methoxy-octen-(2)-saeure-aethylester | 2218-79-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3,7-Dimethyl-7-methoxy-octen-(2)-saeure-aethylester
• 英文别名: 7-Methoxy-3,7-dimethyl-Δ²-octensaeureethylester；7-Methoxy-3,7-dimethyl-oct-2t-en-1-saeure-ethylester；Ethyl 7-methoxy-3,7-dimethyloct-2-enoate；ethyl 7-methoxy-3,7-dimethyloct-2-enoate
• CAS: 2218-79-3
• 化学式: C₁₃H₂₄O₃
• 分子量: 228.332
• InChiKey: IHOUMNYDOHZGKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,7-Dimethyl-7-methoxy-octen-(2)-saeure-aethylester 在 lithium aluminium tetrahydride 作用下， 以 甲醇 、 乙醚 为溶剂， 生成 spirilloxanthin
  参考文献：
  名称：

  Total Synthesis of Spirilloxanthin, Dehydrolycopene, and 1,1'-Dihydroxy-1,2,1',2'-tetrahydrolycopene¹

  摘要：

  DOI：

  10.1021/jo01045a057
• 作为产物：
  描述：

  6-甲基-5-庚烯-2-酮 在 吡啶 、 硫酸 、 potassium bromide 、 锌 、 三氯氧磷 作用下， 以 甲苯 、 苯 为溶剂， 生成 3,7-Dimethyl-7-methoxy-octen-(2)-saeure-aethylester
  参考文献：
  名称：

  Total Synthesis of Spirilloxanthin, Dehydrolycopene, and 1,1'-Dihydroxy-1,2,1',2'-tetrahydrolycopene¹

  摘要：

  DOI：

  10.1021/jo01045a057

文献信息

• COMPOSITION FOR USE IN A METHOD FOR LOWERING OF LDL-CHOLESTEROL IN PLASMA
  申请人：ezCol B.V.

  公开号：EP3897677A1

  公开（公告）日：2021-10-27
• [EN] COMPOSITION FOR USE IN A METHOD FOR LOWERING OF LDL-CHOLESTEROL IN PLASMA<br/>[FR] COMPOSITION À UTILISER DANS UNE MÉTHODE VISANT À ABAISSER LE TAUX PLASMATIQUE DE CHOLESTÉROL LBD
  申请人：EZCOL B V

  公开号：WO2020130813A1

  公开（公告）日：2020-06-25

  The present invention relates to a (pharmaceutical) composition comprising geranyl-geranyl bacteriopheophytin a, phytyl derivative of bacteriopheophytin a, hydroxyspirilloxanthin, rhodovibrin, 3,4- rhodopin, chloroxanthin, rhodopin, spirilloxanthin, 3,4-spirilloxanthin, ubiquinol-10, ubiquinone-9, ubiquinone-10 and rhodoquinone-10, for use in a method for the lowering of LDL-cholesterol in subjects in need thereof. Furthermore, the invention relates to a foodstuff comprising a food supplement, wherein the food supplement has cholesterol-lowering properties and comprises compounds geranyl-geranyl bacteriopheophytin a, phytyl derivative of bacteriopheophytin a, hydroxyspirilloxanthin, rhodovibrin, 3,4- rhodopin, chloroxanthin, rhodopin, spirilloxanthin, 3,4-spirilloxanthin, ubiquinol-10, ubiquinone-9, ubiquinone-10 and rhodoquinone-10. For the pharmaceutical composition and the composition and the food supplement the proviso is that the (pharmaceutical) composition is not, and the compounds are not provided as, a petroleum ether extract of Rhodospirillum rubrum obtainable by extraction of Rhodospirillum rubrum cells with a mixture of petroleum ether with a boiling point of between 60°C and 80°C and methanol comprising sodium chloride, wherein the extract is obtained by extraction for between 10 minutes and 48 hours at between 8°C and 37°C, while mixing the cells with the mixture, and wherein the Rhodospirillum rubrum cells are extracted with the mixture in a volume ratio of between 10:1 and 1:10 of petroleum ether with a boiling point of between 60°C and 80°C and methanol comprising sodium chloride. Furthermore, the (pharmaceutical) composition and compounds are not comprising or provided as whole R.rubrum cells or as a membrane fraction of R.rubrum.
• Total Synthesis of Spirilloxanthin, Dehydrolycopene, and 1,1'-Dihydroxy-1,2,1',2'-tetrahydrolycopene¹
  作者：Joseph D. Surmatis、Alfred Ofner

  DOI：10.1021/jo01045a057

  日期：1963.10