2-methyl-nonanedioic acid | 88107-08-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methyl-nonanedioic acid
• 英文别名: 2-Methyl-nonandisaeure；2-methylnonanedioic acid
• CAS: 88107-08-8
• 化学式: C₁₀H₁₈O₄
• 分子量: 202.251
• InChiKey: XWVFEDFALKHCLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  癸二酸 在 一氧化碳 、 bismuth iodide and carbon monoxide 、 碘 、 镍 作用下， 250.0 ℃ 、19.61 MPa 条件下， 生成 2-methyl-nonanedioic acid
  参考文献：
  名称：

  DE1070164

  摘要：

  公开号：

文献信息

• ELECTROLYTE SALT AND ELECTROLYTE FOR ELECTRICITY STORAGE DEVICE, AND ELECTRICITY STORAGE DEVICE
  申请人：NISSHINBO HOLDINGS INC.

  公开号：US20150291633A1

  公开（公告）日：2015-10-15

  Provided is an electrolyte salt comprising a quaternary ammonium cation indicated by formula (1) and a trimethylsilyl alkanesulfonate anion indicated by formula (2). (In the formula, R 1 -R 4 each independently indicate a C1-4 alkyl group or an alkoxyalkyl group indicated by —(CH 2 ) n —OR. Any two among R 1 -R 4 can mutually bond and form a ring together with a nitrogen atom to which same have bonded. The remaining two can mutually bond and form a spiro ring having a nitrogen atom as the spiro atom therefor. R indicates a methyl group or an ethyl group. n indicates 1 or 2 and m indicates 2 or 3.)

  提供的是一种电解质盐，包括由式（1）表示的季铵阳离子和由式（2）表示的三甲基硅烷烷磺酸盐阴离子。（在式中，R1-R4分别表示一个C1-4烷基或一个由—(CH2)n—OR表示的烷氧基烷基。R1-R4中的任意两个可以相互结合，并与它们结合的氮原子一起形成一个环。其余的两个可以相互结合，并形成一个以氮原子为螺旋原子的螺环。R表示一个甲基或一个乙基。n表示1或2，m表示2或3。）
• Protein Binding Compounds
  申请人：Klaveness Jo

  公开号：US20070259889A1

  公开（公告）日：2007-11-08

  The present invention provides a prodrug compound comprising a therapeutically effective moiety coupled via a metabolically cleavable bond to a blood protein binding moiety.

  本发明提供了一种前药化合物，其包括通过代谢可被切断的键与血液蛋白结合基团耦合的治疗有效基团。
• Compounds
  申请人：Klaveness Jo

  公开号：US20080103110A1

  公开（公告）日：2008-05-01

  The invention provides a water-soluble prodrug compound comprising a therapeutically effective moiety coupled via a metabolically cleavable bond to a protein binding moiety, wherein said therapeutically effective moiety has an anticancer, antiinflammatory, antiinfective or antipain effect, said protein binding moiety binds non-covalently to blood proteins, and the protein binding of said compound is at least 100% higher than that of the therapeutically effective moiety itself, with the exclusion of (i) the monoester of gemcitabine with azelaic acid, (ii) the monoester of dideoxycytidine with 1,12-dodecanedicarboxylic acid, (iii) 2-amino-1,9-dihydro-9(2′-(1-(10-acetyl-decanoyloxy)ethoxymethyl))-guanine, (iv) 5′-cytarabine monoester with 1,4-phenylene diacetic acid, (v) the monoester of metronidazole with 1,4-butanedicarboxylic acid, and (vi) the monoester of metronidazole with 1,6-phenylene diacetic acid; and pre-prodrugs metabolizable thereto.

  本发明提供了一种水溶性前药化合物，其包括通过代谢可裂解键与蛋白结合基团耦合的治疗有效基团，其中所述治疗有效基团具有抗癌、抗炎、抗感染或抗疼痛作用，所述蛋白结合基团与血液蛋白非共价结合，且所述化合物的蛋白结合至少比治疗有效基团本身高100％，不包括（i）阿齐拉酸与吉西他滨的单酯，（ii）1,12-十二烷二羧酸与二脱氧胞苷的单酯，（iii）2-氨基-1,9-二氢-9（2′-（1-（10-乙酰基癸酰氧）乙氧甲基）-鸟嘌呤，（iv）1,4-苯二乙酸单酯的5′-胞嘧啶，（v）1,4-丁二酸单酯的甲硝唑，以及（vi）1,6-苯二乙酸单酯的甲硝唑；以及可代谢为前药的前前药。
• Improved Process for the Production of Derivatives of Saturated Carboxylic Acids
  申请人：Bastioli Catia

  公开号：US20080245995A1

  公开（公告）日：2008-10-09

  A process for the production of carboxylic acids and their derivatives comprising the steps of: (c) reacting a derivative of an unsaturated fatty acid with an oxidizing compound in the presence of a catalyst capable of catalysing the reaction of oxidation of the double olefinic bond of the derivative of the unsaturated fatty acid so as to obtain as intermediate product of reaction a vicinal diol; and (d) reacting said intermediate compound with oxygen, or a compound containing oxygen, in the presence of a catalyst capable of catalysing the reaction of oxidation of the hydroxyl groups of the vicinal diol to carboxylic groups, characterized in that both of the steps (a) and (b) are carried out in the absence of added organic solvent and in that the water/diol ratio in the reaction of step (b) is less than 1:1.

  一种生产羧酸及其衍生物的方法，包括以下步骤：（c）在催化剂的存在下，将不饱和脂肪酸衍生物与氧化剂反应，催化剂能够催化不饱和脂肪酸衍生物的双烯键氧化反应，从而得到邻二醇的中间产物；（d）在催化剂的存在下，将该中间化合物与氧气或含氧化合物反应，催化剂能够催化邻二醇的羟基氧化反应成为羧基，其特征在于步骤（a）和（b）都在无添加有机溶剂的情况下进行，并且步骤（b）中的水/二醇比小于1:1。
• REUSABLE PRINT MEDIUM AND METHOD OF MANUFACTURING THEREOF
  申请人：OCE TECHNOLOGIES B.V.

  公开号：US20130137805A1

  公开（公告）日：2013-05-30

  The present invention relates to a reusable print medium comprising a substrate and a sacrificial layer. The sacrificial layer contains a hotmelt composition at least comprising an amorphous material. The amorphous material is a resin being a reaction product of a first monomer A, said first monomer A being a polyhydroxyl alcohol comprising X hydroxyl functional groups, wherein X≧2, monomer A optionally comprises a primary or secondary amine functionality; a second monomer B, being an aromatic monocarboxylic acid; a third monomer C, said third monomer C being able to form an ester linkage with an alcohol and/or an amide linkage with a primary or secondary amine; and optionally, a fourth monomer D, being an aromatic monocarboxylic acid different from the second monomer B. The sacrificial layer including the printed image may be removed from the substrate by applying heat. A new sacrificial layer may be applied such that the reusable print medium is ready to be reused. The present invention also relates to a method of manufacturing a reusable print medium according to the present invention, a method of printing and recycling such a print medium and an apparatus for printing and recycling such a print medium.

  本发明涉及一种可重复使用的印刷介质，包括基底和牺牲层。牺牲层含有至少包括非晶态材料的热熔组合物。该非晶态材料是一种树脂，是第一单体A的反应产物，第一单体A是一种聚羟基醇，包括X个羟基官能团，其中X≥2，单体A可选包括一种主链或侧链氨基官能团；第二单体B是一种芳香单羧酸；第三单体C能够与醇形成酯键和/或与一种主链或侧链氨基形成酰胺键；可选地，第四单体D是一种与第二单体B不同的芳香单羧酸。可以通过施加热量从基底中去除包括印刷图像的牺牲层。可以应用新的牺牲层，使可重复使用的印刷介质准备好被重用。本发明还涉及一种制造可重复使用的印刷介质的方法，一种印刷和回收这样的印刷介质的方法，以及一种印刷和回收这样的印刷介质的装置。