glycerol-1-lactate | 26855-41-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: glycerol-1-lactate
• 英文别名: Glycerin-1-lactat；Milchsaeure-(2,3-dihydroxy-propylester)；Glycerin-α-lactat；α-Monolactin；Glycerinmonolactat；Glycerin-(1)-lactat；Glycerol monolactate；2,3-dihydroxypropyl 2-hydroxypropanoate
• CAS: 26855-41-4
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: RSGINGXWCXYMQU-UHFFFAOYSA-N

物化性质

• LogP：
  -1.890 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  glycerol-1-lactate 、 乙酸酐 在 吡啶 作用下， 生成 glycerol-1.2-diacetat-3-(2-acetoxy propionate)
  参考文献：
  名称：

  Feldmann; Fischer, Archives of Biochemistry, 1947, vol. 14, p. 117,119

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 作用下， 生成 glycerol-1-lactate
  参考文献：
  名称：

  Feldmann; Fischer, Archives of Biochemistry, 1947, vol. 14, p. 117,119

  摘要：

  DOI：

文献信息

• [EN] CATALYSTS FOR THE TRANSFORMATION OF CARBON DIOXIDE AND GLYCEROL TO FORMIC ACID AND LACTIC ACID AND METHODS OF MAKING THE SAME<br/>[FR] CATALYSEURS POUR LA TRANSFORMATION DE DIOXYDE DE CARBONE ET DE GLYCÉROL EN ACIDE FORMIQUE ET EN ACIDE LACTIQUE ET LEURS PROCÉDÉS DE FABRICATION
  申请人：UNIV GEORGE WASHINGTON

  公开号：WO2018213821A1

  公开（公告）日：2018-11-22

  Catalysts and methods for transformation of glycerol and a carbon feedstock, such as CO2, a carbonate salt or a bicarbonate salt, are described herein. Homogeneous catalysts include compounds of formula M[NHC-R-linker]aLbXc, where M is a transition metal, NHC is an N-heterocyclic carbene ligand, R is an alkyl or aryl group, linker is a polar group, L is a neutral ligand, X is an anionic ligand, a ranges from 1-3, b ranges from 0-3, and c ranges from 0-3. Heterogeneous catalysts include a solid support with a catalytically active compound immobilized on the solid support, where the catalytically active compound has the formula M[NHC-R-linker]aLbXc where M is a transition metal, NHC is an N-heterocyclic carbene ligand, R is an alkyl or aryl group; linker is a polar group, L is a neutral ligand, X is an anionic ligand, a ranges from 1-3, b ranges from 0-3, and c ranges from 0-3.

  本文描述了用于转化甘油和碳原料（如CO2、碳酸盐或碳酸氢盐）的催化剂和方法。均相催化剂包括具有M[NHC-R-linker]aLbXc式化合物的化合物，其中M是过渡金属，NHC是N-杂环卡宾配体，R是烷基或芳基，linker是极性基团，L是中性配体，X是阴离子配体，a范围为1-3，b范围为0-3，c范围为0-3。非均相催化剂包括具有固体支撑物的催化活性化合物固定在固体支撑物上，其中催化活性化合物具有M[NHC-R-linker]aLbXc式化合物，其中M是过渡金属，NHC是N-杂环卡宾配体，R是烷基或芳基；linker是极性基团，L是中性配体，X是阴离子配体，a范围为1-3，b范围为0-3，c范围为0-3。
• APPLICATIONS OF BIOBASED GLYCOL COMPOSITIONS
  申请人：Binder Thomas Paul

  公开号：US20080103340A1

  公开（公告）日：2008-05-01

  A biobased replacement for propylene glycol and ethylene glycol derived from petrochemical sources is presented. The product mixture from the hydrogenolysis of certain polyols from biobased renewable resources may replace propylene glycol and ethylene glycol products from petrochemical sources. Applications and methods of the biobased hydrogenolysis product mixture are disclosed. The compositions and methods provide a feedstock for industrial use which has a 13 C/ 12 C isotope ratio characteristic of bioderived material.

  提出了一种基于生物的替代品，用于丙二醇和乙二醇，这些替代品源自石化来源。从基于生物可再生资源中的某些多元醇的氢解反应产生的产物混合物可以替代石化来源的丙二醇和乙二醇产品。公开了基于生物氢解产物混合物的应用和方法。这些组合物和方法提供了一个13C/12C同位素比特征为生物衍生材料的工业用原料。
• Topical Delivery System for Cosmetic and Pharmaceutical Agents
  申请人：Gupta K. Shyam

  公开号：US20060110415A1

  公开（公告）日：2006-05-25

  This invention relates to topical compositions containing esters of hydroxy acids and their application in the deep-penetration delivery of beneficial cosmetic and pharmaceutical agents.

  本发明涉及含有羟基酸酯的局部组成物，以及它们在深层渗透输送有益的化妆品和药物剂的应用。
• Topical Delivery System for Phytosterols
  申请人：GUPTA SHYAM K.

  公开号：US20090042846A1

  公开（公告）日：2009-02-12

  This invention relates to certain sugar esters of phytosterols of formula (I). These esters are useful for topical application, and for the treatment of skin condition, including age spots, acne, loss of cellular antioxidants, collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles including fine lines, oxidation, damage from radiation, malfunction of matrix metalloproteases, malfunction of tyrosinases, damage from free radicals, damage from UV, dry skin, xerosis, ichthyosis, dandruff, brownish spots, keratoses, melasma, lentigines, liver spots, pigmented spots, dark circles under the eyes, skin pigmentation including darkened skin, blemishes, oily skin, warts, eczema, pruritic skin, psoriasis, inflammatory dermatoses, topical inflammation, disturbed keratinization, skin changes associated with aging, nail or skin requiring cleansers, conditioning or treatment, and hair or scalp requiring shampooing or conditioning, and combinations thereof; Wherein, n=0, 1, 2, or 3; and R=H, —CH 2 OH, —CH(OH)—CH 2 OH, —CH(OH)—CH(OH)—CH 2 OH; and R 1 =Substituent selected from a sapogenin, steroid, or terpenoid.

  本发明涉及公式（I）的植物甾醇糖酯，这些酯类适用于局部应用，并用于治疗皮肤状况，包括老年斑、痤疮、细胞抗氧化剂的丧失、胶原蛋白的丧失、皮肤柔韧性的丧失、皮肤柔软性的丧失、皮肤皱纹包括细纹、氧化、辐射损伤、基质金属蛋白酶的功能障碍、酪氨酸酶的功能障碍、自由基的损伤、紫外线的损伤、干燥皮肤、角化病、鱼鳞病、头皮屑、褐色斑点、角化病、黄褐斑、肝斑、色素斑点、眼圈黑色素沉着、皮肤色素沉着包括皮肤变黑、瑕疵、油性皮肤、疣、湿疹、瘙痒性皮肤、银屑病、炎症性皮肤病、局部炎症、角化异常、与衰老相关的皮肤变化、需要清洁剂、调理剂或治疗剂的指甲或皮肤，以及需要洗发水或护发素的头发或头皮，以及其组合；其中，n = 0、1、2或3；R = H、—CH2OH、—CH（OH）—CH2OH、—CH（OH）—CH（OH）—CH2OH；R1 = 从皂甙、类固醇或萜类中选择的取代基。
• Process for producing polyol fatty acid monoesters
  申请人：LION CORPORATION

  公开号：EP0407959A2

  公开（公告）日：1991-01-16

  A polyol fatty acid monoester can be produced with an industrial advantage at high synthesis ratio upon (1) mixing and reacting a saturated or unsaturated fatty acid having 6 to 22 carbon atoms or an ester of such a fatty acid with a lower alcohol having 1 to 3 carbon atoms and a polyol selected from glycerol and its derivatives, polyglycerol and its derivatives, ethylene glycol, polyethylene glycol, propylene glycol and polypropylene glycol or (2) mixing and reacting a glyceride oil or fat comprising a saturated or unsaturated fatty acid having 6 to 22 carbon atoms as the constituent fatty acid and one or more of the above polyols, wherein an enzymatic reaction is conducted by using an immobilized thermostable lipase under the presence of a secondary or tertiary alcohol.

  (1) 将具有 6 至 22 个碳原子的饱和或不饱和脂肪酸或这种脂肪酸的酯与具有 1 至 3 个碳原子的低级醇和选自甘油及其衍生物、聚甘油及其衍生物、乙二醇、聚乙二醇、丙二醇和聚丙二醇的多元醇混合并反应，或 (2) 将由具有 6 至 22 个碳原子的饱和或不饱和脂肪酸组成的甘油酯油或脂肪与选自甘油及其衍生物、聚甘油及其衍生物、乙二醇、聚乙二醇、丙二醇和聚丙二醇的多元醇混合并反应，可以高合成比生产具有工业优势的多元醇脂肪酸单酯、聚乙二醇、丙二醇和聚丙二醇，或 (2) 混合甘油酯油或脂肪并使其反应，甘油酯油或脂肪的组成脂肪酸为具有 6 至 22 个碳原子的饱和或不饱和脂肪酸，以及一种或多种上述多元醇，其中酶反应是在仲醇或叔醇存在下通过使用固定化恒温脂肪酶进行的。