2-(diethylamino)-N-(2,6-dimethylphenyl)-N-methylacetamide | 31058-85-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(diethylamino)-N-(2,6-dimethylphenyl)-N-methylacetamide
• 英文别名: N-Methyl-2-diethylamino-2',6'-acetoxylidid
• CAS: 31058-85-2
• 化学式: C₁₅H₂₄N₂O
• 分子量: 248.368
• InChiKey: FAKFWYFBBKAMIF-UHFFFAOYSA-N

物化性质

• 沸点：
  360.3±30.0 °C(Predicted)
• 密度：
  1.005±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(diethylamino)-N-(2,6-dimethylphenyl)-N-methylacetamide 在 吡啶 、 盐酸 作用下， 以 水 、 1,2-二氯乙烷 为溶剂， 反应 27.33h， 生成
  参考文献：
  名称：

  Janus颗粒由有机非典型不对称双子表面活性剂自组装而成

  摘要：

  已经制备了一系列具有两性碳酸酯基团（–O–CO–O–）的非典型非对称双子表面活性剂。这些化合物中的一些可以在水中自组装成葫芦形的Janus颗粒（JPs）。初步结果表明，JPs的形成极有可能与它们的非典型双子表面活性剂结构有关。据我们所知，这是关于JP的第一份报告，这些JP是由一种小有机分子自组装而成的。我们相信我们的结果将在许多领域得到利用。

  DOI：

  10.1039/c7cc03973e
• 作为产物：
  描述：

  利多卡因 、 四甲基氟化铵 以 甲苯 为溶剂， 反应 12.0h， 以88%的产率得到2-(diethylamino)-N-(2,6-dimethylphenyl)-N-methylacetamide
  参考文献：
  名称：

  酰胺，N-杂环，硫醇和醇与四甲基氟化铵的选择性甲基化。

  摘要：

  我们在此公开了四甲基氟化铵（TMAF）作为各种酰胺，吲哚，吡咯，咪唑，醇和硫醇的直接和选择性甲基化剂的用途。该方法的特点是操作简单，范围广，纯化容易。我们的计算研究表明，一致的甲基化-去质子化是优选的反应途径。

  DOI：

  10.1021/acs.orglett.9b04400

文献信息

• Multi-API Loading Prodrugs
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20160024011A1

  公开（公告）日：2016-01-28

  The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam-amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.
• [EN] MACROMOLECULAR PRODRUGS FOR LIGHT-EMITTING DIODES AND USES THEREOF<br/>[FR] PROMÉDICAMENTS MACROMOLÉCULAIRES POUR DIODES ÉLECTROLUMINESCENTES ET LEURS UTILISATIONS
  申请人：CHILDRENS MEDICAL CENTER

  公开号：WO2021146553A1

  公开（公告）日：2021-07-22

  Provided herein are compositions comprising macromolecular photocleavable prodrug compounds of Formula (I), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, and isotopically enriched derivatives thereof. Also provided are methods, uses, pharmaceutical compositions, and kits involving the inventive compounds or compositions for treating and/or preventing a disease and/or condition (e.g., inflammatory disease, infectious disease, pain) in a subject, optionally comprising illumination of the compound, composition, or pharmaceutical composition with light of an absorption wavelength sufficient to cleave the bonds between each instance of L and each instance of X upon illumination with the light (e.g., light between approximately 200 nm to 500 nm).
• Janus particles self-assembled from a small organic atypical asymmetric gemini surfactant
  作者：Lei Tang、Jun Yang、Qinqin Yin、Linghui Yang、Deying Gong、Feng Qin、Junyang Liu、Qin Fan、Jiahong Li、Wenling Zhao、Weiyi Zhang、Jiyu Wang、Tao Zhu、Wensheng Zhang、Jin Liu

  DOI：10.1039/c7cc03973e

  日期：——

  A series of atypical asymmetric gemini surfactants with an amphiphilic carbonate group (–O–CO–O–) have been prepared. Some of these compounds could self-assemble in water into gourd-shaped Janus particles (JPs). Initial results suggested that the formation of JPs was highly likely to be related to their atypical gemini surfactant structure. To our knowledge, this is the first report on JPs that are

  已经制备了一系列具有两性碳酸酯基团（–O–CO–O–）的非典型非对称双子表面活性剂。这些化合物中的一些可以在水中自组装成葫芦形的Janus颗粒（JPs）。初步结果表明，JPs的形成极有可能与它们的非典型双子表面活性剂结构有关。据我们所知，这是关于JP的第一份报告，这些JP是由一种小有机分子自组装而成的。我们相信我们的结果将在许多领域得到利用。
• Selective Methylation of Amides, <i>N</i>-Heterocycles, Thiols, and Alcohols with Tetramethylammonium Fluoride
  作者：Hong-Gang Cheng、Maoping Pu、Gourab Kundu、Franziska Schoenebeck

  DOI：10.1021/acs.orglett.9b04400

  日期：2020.1.3

  We herein disclose the use of tetramethylammonium fluoride (TMAF) as a direct and selective methylating agent of a variety of amides, indoles, pyrroles, imidazoles, alcohols, and thiols. The method is characterized by operational simplicity, wide scope, and ease of purification. Our computational studies suggest a concerted methylation-deprotonation as the preferred reaction pathway.

  我们在此公开了四甲基氟化铵（TMAF）作为各种酰胺，吲哚，吡咯，咪唑，醇和硫醇的直接和选择性甲基化剂的用途。该方法的特点是操作简单，范围广，纯化容易。我们的计算研究表明，一致的甲基化-去质子化是优选的反应途径。