N^α,N^ε-Di-tert.-butyloxycarbonyl-lysin-hydrazid | 2592-20-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N^α,N^ε-Di-tert.-butyloxycarbonyl-lysin-hydrazid
• 英文别名: N^α,N^ε-Di-tert.-butyloxycarbonyl-L-lysin-hydrazid；tert-butyl N-[(2S)-1-hydrazinyl-6-[(2-methylpropan-2-yl)oxycarbonylamino]-1-oxohexan-2-yl]carbamate
• CAS: 2592-20-3
• 化学式: C₁₆H₃₂N₄O₅
• 分子量: 360.454
• InChiKey: AWSVTCFVPQJRHC-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N^α,N^ε-Di-tert.-butyloxycarbonyl-lysin-hydrazid 在 一水合肼 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 Boc-Lys(Boc)-Glu(tBu)-Thr-NHNH2
  参考文献：
  名称：

  Scoffone,E. et al., Gazzetta Chimica Italiana, 1964, vol. 94, p. 743 - 759

  摘要：

  DOI：
• 作为产物：
  描述：

  L-赖氨酸盐酸盐 在 sodium carbonate 、 一水合肼 作用下， 反应 2.0h， 生成 N^α,N^ε-Di-tert.-butyloxycarbonyl-lysin-hydrazid
  参考文献：
  名称：

  多肽的研究。二十九。与牛胰核糖核酸酶A的N末端有关的合成肽（位置1-7）。

  摘要：

  DOI：

  10.1021/ja01081a039

文献信息

• 1,6- Diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
  申请人：Patel Mahesh Vithalbhai

  公开号：US20140148431A1

  公开（公告）日：2014-05-29

  Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.

  公式（I）的化合物，其制备和在预防或治疗细菌感染中的应用被披露。
• [EN] 1,3,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS<br/>[FR] COMPOSÉS 1,3,4-OXADIAZOLES ET THIADIAZOLES UTILISÉS COMME IMMUNOMODULATEURS
  申请人：AURIGENE DISCOVERY TECH LTD

  公开号：WO2016142852A1

  公开（公告）日：2016-09-15

  The present invention relates to 1,3,4-oxadiazole and thiadiazole compounds of formula (I) and their use to inhibit the programmed cell death 1 (PD-1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.

  本发明涉及式(I)的1,3,4-噁二唑和噻二唑化合物，以及它们用于抑制程序性细胞死亡1（PD-1）信号通路和/或通过抑制由PD-1、PD-L1或PD-L2诱导的免疫抑制信号治疗疾病。
• Nitrogen containing compounds
  申请人：PATEL Mahesh Vithalbhai

  公开号：US20150005285A1

  公开（公告）日：2015-01-01

  Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.

  本发明揭示了公式（I）的化合物，它们的制备以及在预防或治疗细菌感染方面的用途。
• NITROGEN CONTAINING COMPOUNDS
  申请人：PATEL Mahesh Vithalbhai

  公开号：US20150174133A1

  公开（公告）日：2015-06-25

  Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.

  公开了化学式(I)的化合物的制备和在预防或治疗细菌感染中的应用。
• Universal Peptidomimetics
  作者：Eunhwa Ko、Jing Liu、Lisa M. Perez、Genliang Lu、Amber Schaefer、Kevin Burgess

  DOI：10.1021/ja1071916

  日期：2011.1.26

  This paper concerns peptidomimetic scaffolds that can present side chains in conformations resembling those of amino acids in secondary structures without incurring excessive entropic or enthalpic penalties. Compounds of this type are referred to here as minimalist mimics. The core hypothesis of this paper is that small sets of such scaffolds can be designed to analogue local pairs of amino acids (including noncontiguous ones) in any secondary structure; i.e., they are universal peptidomimetics. To illustrate this concept, we designed a set of four peptidomimetic scaffolds. Libraries based on them were made bearing side chains corresponding to many of the protein-derived amino acids. Modeling experiments were performed to give an indication of kinetic and thermodynamic accessibilities of conformations that can mimic secondary structures. Together, peptidomimetics based on these four scaffolds can adopt conformations that resemble almost any combination of local amino acid side chains in any secondary structure. Universal peptidomimetics of this kind are likely to be most useful in the design of libraries for high-throughput screening against diverse targets. Consequently, data arising from submission of these molecules to the NIH Molecular Libraries Small Molecule Repository (MLSMR) are outlined.