Zn-Met₂ | 64364-41-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Zn-Met₂
• 英文别名: bis(DL-methionato-N,O-)-zinc；methionine zinc complex；DL-methionine zinc salt；ZINC;2-amino-4-methylsulfanylbutanoate
• CAS: 64364-41-6
• 化学式: C₁₀H₂₀N₂O₄S₂Zn
• 分子量: 361.802
• InChiKey: CNMFGFBWPBBGKX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -2.37
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  183
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  DL-蛋氨酸 生成 Zn-Met₂
  参考文献：
  名称：

  SIZOV, S. YU.;RAZMEROVA, N. N., XIMIYA I TEXNOL. EHLEMENTOORGAN. POLUPRODUKTOV I POLIMEROV, VOLGOGRAD, 19+

  摘要：

  DOI：

文献信息

• ENERGY-EFFICIENT SOLVENT-FREE METHOD FOR PRODUCING METAL CHELATES
  申请人：TECHNISCHE UNIVERSITAT CLAUSTHAL

  公开号：US20210309674A1

  公开（公告）日：2021-10-07

  The invention relates to a method for producing, amongst other things, amino-acid and/or hydroxycarboxylic-acid metal chelates, a solvent-free mixture of at least one metal oxide, metal hydroxide, metal carbonate or oxalate, and the solid organic acid is subjected to intensive mechanical stress. According to the invention, this is done in that the reaction partners are introduced in particle form into a fluid stream of a fluid-bed countercurrent mill operating without grinding elements, wherein mechanical activation of at least one of the reaction partners is effected by collision processes within a reaction chamber formed in a region of the fluid stream, and a solid body reaction to form the metal chelate is triggered. The novel method operates very energy-efficiently and with a high specific yield. It leads to a product having compact particles in the small, single-digit micrometer range having a comparatively narrow particle size distribution and a large surface. The product is homogenous and very pure. Thermal loading or decomposition of the organic chelate ligands, in particular of the amino acids, is likewise avoided, as are contaminants from milling and grinding element abrasion.

  该发明涉及一种制备氨基酸和/或羟基羧酸金属螯合物的方法，其中包括无溶剂的至少一种金属氧化物、金属氢氧化物、金属碳酸盐或草酸盐的混合物，以及将固体有机酸受到强烈机械应力。根据该发明，通过将反应物以颗粒形式引入无磨粒元素运行的流化床逆流磨中，其中至少一个反应物的机械活化通过在流体流动区域内形成的反应室内的碰撞过程来实现，并触发形成金属螯合物的固体体反应。这种新方法运行非常节能，并具有高特定产量。它导致产物具有在小型、个位数微米范围内的致密颗粒，具有相对较窄的颗粒大小分布和大表面。该产品是均匀且非常纯净的。同时也避免了有机螯合配体（特别是氨基酸）的热负荷或分解，以及来自磨削和磨粒元素磨损的污染物。
• METHIONINE-METAL CHELATE AND MANUFACTURING METHOD THEREOF
  申请人：CJ CHEILJEDANG CORPORATION

  公开号：US20200157121A1

  公开（公告）日：2020-05-21

  The present disclosure relates to a preparation method of a methionine-metal chelate, and the methionine-metal chelate, which is prepared by first reacting Ca(OH) 2 and methionine and adding metal chloride salts, can be used as feeds and feed additives.

  本公开涉及一种蛋氨酸-金属螯合物的制备方法，首先通过将Ca(OH)2和蛋氨酸反应，然后加入金属氯化盐制备蛋氨酸-金属螯合物，可用作饲料和饲料添加剂。
• The inhibitory effect of the amino acid complexes of Zn(II) on the growth of Aspergillus flavus and aflatoxin B1 production
  作者：Marzieh Daryanavard、Nafiseh Jarrah

  DOI：10.1007/s13738-018-01581-3

  日期：2019.5

  coordinated in 1 and 2, respectively. Furthermore, the antifungal activity of the synthesized complexes was investigated against the Aspergillus flavus fungus. The aqueous solutions of the zinc(II) amino acid complexes at various concentrations were added to the potato dextrose agar (PDA) medium containing spores of Aspergillus flavus, and the mixtures were then incubated at 25–30 °C for 6 days. The

  锌（II）与氨基酸作为配体的Zn（Gln）2（1），[Zn（Arg）2（OAc）] OAc·3H 2 O（2），Zn（His）2（3）， Zn（Gly）2（4），Zn（Met）2（5）和Zn（Cys）2（6）（Gln =谷氨酰胺，Arg =精氨酸，His =组氨酸，Gly =甘氨酸，Met =蛋氨酸和Cys =半胱氨酸）已在水溶液中合成，并通过元素分析和光谱学方法进行了表征。此外，固态结构1和2已经通过单晶X射线晶体学确定。X射线分析表明，中心Zn（II）原子在1和2中分别为6和5配位。此外，研究了合成的复合物对黄曲霉真菌的抗真菌活性。将各种浓度的锌（II）氨基酸复合物的水溶液添加到含有黄曲霉孢子的马铃薯葡萄糖琼脂（PDA）培养基中，然后将混合物在25–30°C下孵育6天。使用酶联免疫吸附测定（ELISA）测量体外产生的黄曲霉毒素B 1。这些复合物浓度的增加降低了因此，黄曲霉和黄曲霉毒素B
• SINGLE POT PROCESS FOR PREPARING METAL PICOLINATES FROM ALPHA PECOLINE
  申请人：——

  公开号：US20020177584A1

  公开（公告）日：2002-11-28

  The present invention relates to a single pot process for the preparation of metal picolinates useful as dietary supplement from alpha picoline, said process comprising hydrosulphonation of alpha picoline with sulphuric acid; heating the reaction mixture thus obtained between the range of 150° to 210 ° C. followed by oxidation with any suitable oxidizing agent to obtain alpha picolinic acid sulphate, and treating the thus obtained alpha picolinic acid sulphate with a metal salt solution to obtain corresponding metal picolinate.

  本发明涉及一种单锅法制备金属吡啶酸盐的方法，该方法从α-吡啶酮中制备出有用的膳食补充剂。该方法包括将α-吡啶酮通过硫酸进行氢磺化反应，然后将所得的反应混合物在150℃至210℃的范围内加热，然后用任何合适的氧化剂进行氧化，以得到α-吡啶酸硫酸盐，并将得到的α-吡啶酸硫酸盐与金属盐溶液处理，以得到相应的金属吡啶酸盐。
• Multifunction "Crown Complexes" from Amino Acids and Peptides for Skin and Hair Restoration
  申请人：Gupta K Shyam

  公开号：US20070099886A1

  公开（公告）日：2007-05-03

  This invention relates to Schiff's bases derived from amino acids and hydroxyaryl alkyl ketones, or a plant extract containing the same, having general chemical structure in FIG. 1 for topical application. This invention also relates to certain metal complex of said Schiff's bases, which have a crown-like appearance in their three-dimensional chemical structure, as in FIG. 2 . The Schiff's bases and their metal complexes of the present invention are useful for the modulation of metal-activated enzymes and metalloenzymes, such as Phenylalanine Hydroxylase, Tyrosine Transaminase, Phenylalanine Transaminase, Tyrosinase, various MMP (Matrix metalloproteases), Superoxide dismutase, 5-Alpha Reductase, and citrate lyase. These are further suitable for multifunctional topical methods for skin whitening, skin wrinkles reduction, skin antiaging, collagen synthesis, acne control, hair loss prevention, hair graying control, and facial oil control.

  本发明涉及从氨基酸和羟基芳基烷基酮衍生的席夫碱，或含有该类化合物的植物提取物，其具有图1中的一般化学结构，用于局部应用。本发明还涉及所述席夫碱的某些金属配合物，其在三维化学结构中呈冠状外观，如图2所示。本发明的席夫碱及其金属配合物对于调节金属活化酶和金属酶，例如苯丙氨酸羟化酶、酪氨酸转氨酶、苯丙氨酸转氨酶、酪氨酸酶、各种基质金属蛋白酶、超氧化物歧化酶、5α-还原酶和柠檬酸裂解酶具有用途。此外，它们还适用于多功能局部方法，如美白肌肤、减少皮肤皱纹、抗衰老、胶原蛋白合成、控制痤疮、预防脱发、控制白发和面部油脂控制。