Disuccinimidyl malate | 675594-68-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Disuccinimidyl malate
• 英文别名: bis(2,5-dioxopyrrolidin-1-yl) 2-hydroxybutanedioate
• CAS: 675594-68-0
• 化学式: C₁₂H₁₂N₂O₉
• 分子量: 328.235
• InChiKey: ZYIRJQHIDRZHAA-UHFFFAOYSA-N

物化性质

• 沸点：
  514.6±60.0 °C(Predicted)
• 密度：
  1.68±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  148
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 苹果酸 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 24.0h， 生成 Disuccinimidyl malate
  参考文献：
  名称：

  Biological cross-linked high-molecular weight derivative

  摘要：

  公开号：

  EP1548004B1

文献信息

• TISSUE ADHESIVE FILM AND METHOD FOR PRODUCING SAME
  申请人：National Institute for Materials Science

  公开号：EP2626087A1

  公开（公告）日：2013-08-14

  The present invention addresses the problem of providing: a tissue adhesive film having high adhesive strength and high biocompatibility; and a method for producing the tissue adhesive film. This problem can be solved by using a tissue adhesive film comprising an integration of gelatin and cross-linking reagents, wherein the gelatin is provided with an amino group on the side chain thereof and has a molecular weight of 50,000 or higher and 100,000 or lower, and the cross-linking reagents have two or more active ester groups or an anhydride.

  本发明所要解决的问题是：提供一种具有高粘合强度和高生物相容性的组织粘合膜；以及一种生产该组织粘合膜的方法。这个问题可以通过使用一种由明胶和交联试剂整合而成的组织胶膜来解决，其中明胶的侧链上带有氨基，分子量在 50,000 或更高和 100,000 或更低之间，交联试剂具有两个或两个以上的活性酯基或酸酐。
• ADHESIVE BONE FILLER AND ADHESIVE BONE FILLER KIT
  申请人：National Institute for Materials Science

  公开号：EP2974752A1

  公开（公告）日：2016-01-20

  Provided is an adhesive bone filling agent which adheres to bone tissue and hardens, and the adhesive bone filling agent is prepared by mixing a liquid component composed of a buffer solution comprising a water-soluble biocompatible polymer with a powder component comprising calcium phosphate and an organic acid-based crosslinking agent.

  本发明提供了一种可粘附在骨组织上并硬化的粘合骨填充剂，该粘合骨填充剂的制备方法是将由水溶性生物相容性聚合物组成的缓冲溶液构成的液体成分与由磷酸钙和有机酸基交联剂构成的粉末成分混合。
• Tissue Adhesive Film and Method for Producing Same
  申请人：Taguchi Tetsushi

  公开号：US20130211048A1

  公开（公告）日：2013-08-15

  The present invention addresses the problem of providing: a tissue adhesive film having high adhesive strength and high biocompatibility; and a method for producing the tissue adhesive film. This problem can be solved by using a tissue adhesive film comprising an integration of gelatin and cross-linking reagents, wherein the gelatin is provided with an amino group on the side chain thereof and has a molecular weight of 50,000 or higher and 100,000 or lower, and the cross-linking reagents have two or more active ester groups or an anhydride.
• ADHESIVE BONE FILLING AGENT AND ADHESIVE BONE FILLING AGENT KIT
  申请人：NATIONAL INSTITUTE FOR MATERIALS SCIENCE

  公开号：US20160008507A1

  公开（公告）日：2016-01-14

  Provided is an adhesive bone filling agent which adheres to bone tissue and hardens, and the adhesive bone filling agent is prepared by mixing a liquid component composed of a buffer solution comprising a water-soluble biocompatible polymer with a powder component comprising calcium phosphate and an organic acid-based crosslinking agent.
• CONTROLLED HEAT DELIVERY COMPOSITIONS
  申请人：BAMBU VAULT LLC

  公开号：US20220218878A1

  公开（公告）日：2022-07-14

  The disclosure describes a heat delivery medium and composition for biomedical applications with controlled conversion of energy from an exogenous source to heat.