methoxy-prop-2-enoate | 139378-53-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methoxy-prop-2-enoate
• 英文别名: methoxypropaneenoate；2-methoxy acrylate；2-Methoxyacrylate；methoxypropenoate；methoxy-acrylate；methoxyacrylate；2-methoxyprop-2-enoate
• CAS: 139378-53-3
• 化学式: C₄H₅O₃
• 分子量: 101.082
• InChiKey: LQAQMOIBXDELJX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methoxy-prop-2-enoate 在 高氯酸 作用下， 生成 丙酮酸
  参考文献：
  名称：

  5-烯醇丙酮酸莽草酸酯 3-磷酸酯 (EPSP) 的酸催化水解及其乙烯基醚官能团的一些简单模型

  摘要：

  在浓和稀无机酸溶液、羧酸和缓冲液中测量了 5-烯醇丙酮酸莽草酸酯 (EPSP)、α-甲氧基丙烯酸和 α-甲氧基丙烯酸甲酯的乙烯基醚官能团的水解速率，并构建了速率曲线如此获得的数据

  DOI：

  10.1021/ja00033a039

文献信息

• NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：HECKEL Armin

  公开号：US20130143892A1

  公开（公告）日：2013-06-06

  The present invention relates to compounds of general formula I, wherein R 1 , L P , HetAr, Ar, and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

  本发明涉及一般式I的化合物，其中R1，LP，HetAr，Ar和n如本申请中所定义，具有有价值的药理学性质，特别是与GPR119受体结合并调节其活性。
• N-CYCLOPROPYL-N-PIPERIDINYL-AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF
  申请人：HIMMELSBACH Frank

  公开号：US20140031369A1

  公开（公告）日：2014-01-30

  The present invention relates to compounds of general formula I, wherein R 1 , L P , (Het)Ar 1 , (Het)Ar 2 and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

  本发明涉及一般式I的化合物，其中R1，LP，（Het）Ar1，（Het）Ar2和n如申请中所定义，具有有价值的药理学性质，特别是能够结合到GPR119受体并调节其活性。
• N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions containing them and uses thereof
  申请人：Himmelsbach Frank

  公开号：US08927726B2

  公开（公告）日：2015-01-06

  The present invention relates to compounds of general formula I, wherein R1, LP, (Het)Ar1, (Het)Ar2 and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

  本发明涉及一般式I的化合物，其中R1，LP，（Het）Ar1，（Het）Ar2和n如本申请所定义，具有有价值的药理学特性，特别是结合到GPR119受体并调节其活性。
• N-cyclopropyl-N-piperidinyl-amide derivatives, pharmaceutical compositions and uses thereof
  申请人：Heckel Armin

  公开号：US08921398B2

  公开（公告）日：2014-12-30

  The present invention relates to compounds of general formula I, wherein R1, LP, HetAr, Ar, and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

  本发明涉及一般式I的化合物，其中R1、LP、HetAr、Ar和n如本申请所定义，具有有价值的药理学特性，特别是能够结合GPR119受体并调节其活性。
• Acid-catalyzed hydrolysis of 5-enolpyruvylshikimate 3-phosphate (EPSP) and some simple models of its vinyl ether functional group
  作者：A. Jerry Kresge、Mordechai Leibovitch、James A. Sikorski

  DOI：10.1021/ja00033a039

  日期：1992.3

  Rates of hydrolysis of the vinyl ether functional groups of 5-enolpyruvylshikimate 3-phosphate (EPSP), α-methoxyacrylic acid, and methyl α-methoxyacrylate were measured in concentrated and dilute mineral acid solutions and carboxylic and buffers, and rate profiles were constructed from the data so obtained

  在浓和稀无机酸溶液、羧酸和缓冲液中测量了 5-烯醇丙酮酸莽草酸酯 (EPSP)、α-甲氧基丙烯酸和 α-甲氧基丙烯酸甲酯的乙烯基醚官能团的水解速率，并构建了速率曲线如此获得的数据