(2-Phenoxy-aethyl)-hydrazin | 3184-38-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2-Phenoxy-aethyl)-hydrazin
• 英文别名: (2-Phenoxyethyl)hydrazine；2-phenoxyethylhydrazine
• CAS: 3184-38-1
• 化学式: C₈H₁₂N₂O
• 分子量: 152.196
• InChiKey: JVQBFZMPFQQOMQ-UHFFFAOYSA-N

物化性质

• 熔点：
  105-110 °C
• 沸点：
  279-281 °C(Press: 764 Torr)
• 密度：
  1.068±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  47.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-Phenoxy-aethyl)-hydrazin 在 氧气 作用下， 以 苯 为溶剂， 生成 5-phenoxypentan-2-one
  参考文献：
  名称：

  Hydroxyalkylation with .alpha.-hydroperoxydiazenes. Alcohols from olefins and carbonyl compounds from enol ethers

  摘要：

  DOI：

  10.1021/jo00176a023
• 作为产物：
  描述：

  2-苯氧乙基溴 在 乙醇 、 一水合肼 作用下， 生成 (2-Phenoxy-aethyl)-hydrazin
  参考文献：
  名称：

  Gabriel, Chemische Berichte, 1914, vol. 47, p. 3030

  摘要：

  DOI：

文献信息

• Synthesis and hypoglycemic activity of N-alkylated hydrazonopropionic acids
  作者：Hans Peter Wolff、Hans F. Kuehnle

  DOI：10.1021/jm00148a011

  日期：1985.10

  A series of N-alkylated 2-hydrazonopropionic acids have been synthesized and evaluated for their hypoglycemic activity. Most of the compounds exhibit a remarkable blood glucose lowering activity in fasted guinea pigs. Some of the structural variables studied were the effects of branching, unsaturation, or substitution on the alkyl side chain and the effect of nuclear substitution on the aralkyl analogues

  已经合成了一系列的N-烷基化的2-肼基丙酸并评估了它们的降血糖活性。大多数化合物在禁食的豚鼠中表现出显着的降血糖活性。研究的一些结构变量是支链，不饱和键或取代基对烷基侧链的影响以及核取代基对芳烷基类似物的影响。从这些化合物中，选择2-[[[（E）-2-甲基-3-苯基-2-丙烯基] azo酰基]丙酸（BM 42.304; 42）进行进一步研究。
• Pyrazol-5-ones
  申请人：Bayer Aktiengesellschaft

  公开号：US03952008A1

  公开（公告）日：1976-04-20

  1-Substituted pyrazole-5-ones of the formula ##SPC1## And pharmaceutically acceptable, nontoxic salts thereof, Wherein R is hydrogen or amino; R.sup.1 is hydrogen, alkyl, alkenyl, unsubstituted or substituted aryl or unsubstituted or substituted aralky; X is A. ethylene, ethylene wherein 1 hydrogen atom on one of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, ethylene wherein 1 hydrogen atom on each of the two carbon atoms is substituted by alkyl of 1 to 4 carbon atoms or said ethylene which is linked to R.sup.2 via an oxygen or sulphur atom; B. propenyl, propenyl wherein 1 hydrogen atom on one, two or three of the carbon atoms is substituted by alkyl of 1 to 4 carbon atoms, said propenyl being linked to the N.sup.1 atom of the pyrazol ring via its methylene moiety; or C. methylene; provided that when X is methylene, R.sup.1 is not hydrogen if R is amino; R.sup.2 is aryl unsubstituted or substituted by: A. 1 or 2 of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms and lower alkoxy; B. cycloalkyl of 5, 6 or 7 carbon atoms or cycloalkenyl of 5, 6 or 7 carbon atoms; C. alkylamino, dialkylamino, cyano, trifluoromethoxy, nitro, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, or said carbamoyl wherein the nitrogen atom is a member of a heterocyclic ring, sulphamyl, alkylsulphamyl, dialkylsulphamyl, or said sulphamyl wherein the nitrogen is a member of a heterocyclic ring, or --SO.sub.n alkyl wherein n is 0, 1 or 2; D. alkylamino, dialkylamino, cyano, trifluoromethoxy, nitro, carbamoyl, alkylcarbamoyl, dialkylcarbamoyl, or said carbamoyl wherein the nitrogen atom is a member of a heterocyclic ring, sulphamyl, alkylsulphamyl, dialkylsulphamyl or said sulphamyl wherein the nitrogen is a member of a heterocyclic ring, or --SO.sub.n alkyl wherein n is 0, 1 or 2, and 1 or 2 of the same or different substituents selected from the group consisting of alkyl, alkenyl, alkoxy, halogen, and trifluoromethyl; or E. a fused, saturated or unsaturated 5-, 6-, or 7-membered ring or said ring containing 1 or 2 oxygen or sulphur atoms; Are useful for their diuretic, saluretic, antihypertensive and antithrombotic effects.

  式为## SPC1 ##的1-取代吡唑-5-酮及其药学上可接受的、无毒的盐，其中R为氢或氨基；R.sup.1为氢、烷基、烯基、未取代或取代的芳基或未取代或取代的芳基烷基；X为A.乙烯，其中一个碳原子上的1个氢原子被1-4个碳原子的烷基取代，两个碳原子上的每个氢原子都被1-4个碳原子的烷基取代，或通过氧或硫原子与R.sup.2连接的乙烯；B.丙烯基，其中一个、两个或三个碳原子上的1个氢原子被1-4个碳原子的烷基取代，该丙烯基通过其亚甲基部分与吡唑环的N.sup.1原子连接；或C.亚甲基；但当X为亚甲基时，若R为氨基，则R.sup.1不为氢；R.sup.2为未取代或取代的芳基，该芳基被以下1种或2种相同或不同的取代基取代：A.卤素、三氟甲基、1-8个碳原子的烷基、2-8个碳原子的烯基和较低的烷氧基中的1种或2种；B.5、6或7个碳原子的环烷基或5、6或7个碳原子的环烯基；C.烷基氨基、二烷基氨基、氰基、三氟甲氧基、硝基、氨基甲酰基、烷基氨甲酰基、二烷基氨甲酰基或其中的氮原子是杂环环的羧酰基，磺酰氨基、烷基磺酰氨基、二烷基磺酰氨基或其中的磺酰氨基是杂环环的，或--SO.sub.n烷基，其中n为0、1或2；D.烷基氨基、二烷基氨基、氰基、三氟甲氧基、硝基、氨基甲酰基、烷基氨甲酰基、二烷基氨甲酰基或其中的氮原子是杂环环的羧酰基，磺酰氨基、烷基磺酰氨基、二烷基磺酰氨基或其中的磺酰氨基是杂环环的，或--SO.sub.n烷基，其中n为0、1或2，以及来自以下群组中1种或2种相同或不同的取代基：烷基、烯基、烷氧基、卤素和三氟甲基；或E.融合的、饱和的或不饱和的5、6或7元环，或含有1或2个氧或硫原子的环，具有利尿、盐利尿、降压和抗血栓作用。
• O-Alkyl-O-[5-chloro-1,2,4-triazol(3)yl]-thiono(thiol)-phosphoric
  申请人：Bayer Aktiengesellschaft

  公开号：US04081535A1

  公开（公告）日：1978-03-28

  O-Alkyl-O-[5-chloro-1,2,4-triazol(3)yl]-thiono(thiol)-phosphoric (phosphonic) acid esters and ester-amides of the formula ##STR1## in which R is alkyl with 1 to 6 carbon atoms, R.sub.1 is alkyl, alkoxy, alkylthio or monoalkylamino each with 1 to 6 carbon atoms, and R.sub.2 is alkylthioalkyl with 1 to 4 carbon atoms per alkyl radical, alkenyl with 2 to 5 carbon atoms, carbalkoxyalkyl with 1 to 4 carbon atoms per alkyl radical, 1-methyl-2-cyanoethyl, or phenoxyalkyl with 1 to 4 carbon atoms in the alkyl radical and optionally substituted on the phenyl radical by at least one of halogen, cyano, or alkylthio or alkyl each with 1 to 4 carbon atoms, Which possess arthropodicidal and nematicidal properties.

  该文本描述的是一类具有节肢动物杀虫和线虫杀虫特性的化合物，其化学式为：##STR1## 其中R为1至6个碳原子的烷基，R.sub.1为1至6个碳原子的烷基、烷氧基、烷基硫基或单烷基氨基，R.sub.2为每个烷基基团含有1至4个碳原子的烷基硫基烷基、2至5个碳原子的烯基、每个烷基基团含有1至4个碳原子的羧甲氧基烷基、1-甲基-2-氰基乙基或每个烷基基团含有1至4个碳原子的苯氧基烷基，且苯基基团上可选地被至少一种卤素、氰基或1至4个碳原子的烷基硫基或烷基取代。这些化合物是O-烷基-O-[5-氯-1,2,4-三唑(3)基]-硫代(硫醇)-磷酸(膦酸)酯和酯酰胺。
• 3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation
  作者：Fortuna Haviv、James D. Ratajczyk、Robert W. DeNet、Francis A. Kerdesky、Roland L. Walters、Steven P. Schmidt、James H. Holms、Patrick R. Young、George W. Carter

  DOI：10.1021/jm00117a010

  日期：1988.9

  3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural test these compounds were effective in reducing exudate volume and accumulation of white blood cells. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin. The structural requirements for inhibiting the Arthus reactions were studied by systematic chemical modification of 1. These structure-activity relationship studies revealed that nitrogen 1' of the hydrazino group is essential for activity and must be electron rich, whereas chemical modifications of other sites of 1 had only a modest effect on activity.
• Aryloxyalkylaminoguanidines. Their Synthesis and Biological Properties
  作者：J. Augstein、S. M. Green、A. M. Monro、T. I. Wrigley、A. R. Katritzky、G. J. T. Tiddy

  DOI：10.1021/jm00315a024

  日期：1967.5