6-aminohexanethiol | 67283-39-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 英文名称: 6-aminohexanethiol
• 英文别名: 6-Aminohexane-1-thiol
• CAS: 67283-39-0
• 化学式: C₆H₁₅NS
• mdl: MFCD19204778
• 分子量: 133.258
• InChiKey: WYYXDSQOPIGZPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-aminohexanethiol 在 双氧水 作用下， 以 水 为溶剂， 以90%的产率得到dithiobis(6-hexaneamine)
  参考文献：
  名称：

  Synthesis of symmetrical thiol-adenosine conjugate and 5′ thiol-RNA preparation by efficient one-step transcription

  摘要：

  A symmetrical transcription initiator containing two adenosines and conjugated thiol functionality (ThioAMP dimer) is chemically synthesized. Transcription in the presence of ThioAMP dimer under the T7 Phi 2.5 promoter yields 5' thiol-labeled RNA (5' HS-RNA) with up to 90% labeling efficiency, depending on the concentration ratio of ThioAMP dimer to ATP. The resulting 5' HS-RNA may be used directly or after thiopropyl Separose 6B affinity column purification. Biotinylation of 5' HS-RNA and formation of gold nanoparticle-RNA nanoplexes are demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.08.097
• 作为产物：
  描述：

  6-碘-1-己烯 在 一水合肼 作用下， 以 甲醇 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 6-aminohexanethiol
  参考文献：
  名称：

  在Au表面上具有自组装的功能化β-环糊精单分子层的对映体的手性鉴别

  摘要：

  设计了一条容易的合成巯基官能化的β-环糊精的合成路线，并将其自行组装到石英晶体微量天平（QCM）的金电极上，以提供一种能够对映异构体进行手性鉴别的耐用传感器。

  DOI：

  10.1016/s0040-4039(02)00267-8

文献信息

• [EN] CHEMOSELECTIVE THIOL-CONJUGATION WITH ALKENE OR ALKYNE-PHOSPHONAMIDATES<br/>[FR] CONJUGAISON CHIMIOSÉLECTIVE D'UN THIOL AVEC DES ALCÈNE- OU ALCYNE-PHOSPHONAMIDATES
  申请人：FORSCHUNGSVERBUND BERLIN EV

  公开号：WO2018041985A1

  公开（公告）日：2018-03-08

  Disclosed are novel conjugates and processes for the preparation thereof. A process for the preparation of alkene- or alkyne-phosphonamidates comprises the steps of (I) reacting a compound of formula (III), with an azide of formula (IV), to prepare a compound of formula (V), reacting a compound of formula (V) with a thiol-containing molecule of formula (VI), resulting in a compound of formula (VII).

  揭示了新颖的结合物和其制备方法。一种制备烯烃或炔烃磷酰胺酯的方法包括以下步骤：(I)将式（III）的化合物与式（IV）的叠氮化合物反应，制备出式（V）的化合物，将式（V）的化合物与式（VI）的含硫醇分子反应，得到式（VII）的化合物。
• [EN] NEW BORANOPHOSPHATE ANALOGUES OF CYCLIC NUCLEOTIDES<br/>[FR] NOUVEAUX ANALOGUES BORANOPHOSPHATES DE NUCLÉOTIDES CYCLIQUES
  申请人：BIOLOG LIFE SCIENCE INST FORSCHUNGSLABOR UND BIOCHEMICA VERTRIEB GMBH

  公开号：WO2012130829A1

  公开（公告）日：2012-10-04

  The present invention relates to novel boranophosphate analogues of cyclic nucleotides. The invention further relates to the use of such compounds as reagents for signal transduction research or as modulators of cyclic nucleotide-regulated binding proteins and isoenzymes thereof, and/or as hydrolysis- and oxidation-resistant ligands for affinity chromatography, for antibody production or for diagnostic applications e.g. on chip surfaces and/or as additive for organ transplantation storage solutions.

  本发明涉及新型硼磷酸酯类环核苷酸类似物。该发明进一步涉及将这类化合物用作信号转导研究的试剂或用作调节环核苷酸调控的结合蛋白和同工酶的调节剂，和/或用作亲和层析的水解和氧化抗性配体，用于抗体生产或诊断应用，例如在芯片表面，和/或作为器官移植保存溶液的添加剂。
• Novel carbapenum derivatives
  申请人：——

  公开号：US20030027809A1

  公开（公告）日：2003-02-06

  An objective of the present invention is to provide carbapenem derivatives which have potent antibiotic activity against MRSA, PRSP, Influenzavirus, and &bgr;-lactamase-producing bacteria and are stable against DHP-1. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts thereof: 1 wherein R 1 represents H or methyl; R 2 and R 3 represent H, a halogen atom, alkyl or the like; and R 4 represents substituted lower alkylthio or the like.

  本发明的目的在于提供对MRSA、PRSP、流感病毒和β-内酰胺酶产生菌具有强大抗菌活性的碳青霉烯衍生物，并且对DHP-1稳定。根据本发明的化合物是由公式(I)表示的化合物或其药物可接受的盐： 1 其中R 1 代表H或甲基；R 2 和R 3 代表H、卤素原子、烷基等；R 4 代表取代的下级烷基硫或类似物。
• [EN] DYE COMPOSITIONS, METHODS OF PREPARATION, CONJUGATES THEREOF, AND METHODS OF USE<br/>[FR] COMPOSITIONS DE COLORANT, PROCÉDÉS DE PRÉPARATION, CONJUGUÉS ASSOCIÉS, ET PROCÉDÉS D'UTILISATION
  申请人：UNIV CORNELL

  公开号：WO2013109859A1

  公开（公告）日：2013-07-25

  Dye compounds of the formula (1) wherein A is a protective agent group that has a characteristic of modifying the singlet-triplet occupancy of the shown cyanine moiety, and M is a reactive crosslinking group or a group that can be converted to a reactive crosslinking group. Methods for synthesizing the dye compounds and applications for their use are also described.

  化合物的染料的公式（1），其中A是一种保护剂基团，具有修改所示青菁基团的单三态占据特性，而M是一种反应性交联基团或可转化为反应性交联基团的基团。还描述了合成染料化合物的方法以及它们的用途。
• CHEMICAL FILM ON SUBSTRATE AND METHOD OF FORMING THE SAME, METHOD OF FORMING PARACYCLOPHANE CONTAINING FUNCTIONAL GROUND WITH DISULFIDE BOND
  申请人：MAY-HWA ENTERPRISE CORPORATION

  公开号：US20170166520A1

  公开（公告）日：2017-06-15

  The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3′-dithiodipropionic acid (DPDPA) and N-ethyl-N′-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.

  本发明提供了一种形成含二硫醚官能团的对环辛苯的方法。通过将3,3′-二硫代丙酸（DPDPA）和N-乙基-N′-(3-（二甲基氨基）丙基)碳二亚胺（EDC）加入4-氨甲基[2,2]对环辛苯制备对环辛苯。本发明还提供了一种化学膜和形成该化学膜的方法。该化学膜含有具有二硫醚官能团的聚对-二甲苯，并通过化学气相沉积过程在基底上形成。