1-(2-aminoethylamino)anthracene-9,10-dione | 69940-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-(2-aminoethylamino)anthracene-9,10-dione
• 英文别名: 1-(2-aminoethylamino)anthraquinone；1-<(2-aminoethyl)amino>anthraquinone；1-(2-aminoethylamino)-9,10-anthraquinone；1-[N-(2-aminoethyl)amino]anthraquinone；2-aminoethylaminoanthracene-9,10-dione；1-(2-aminoethyl)aminoanthraquinone；1-(2-Amino-ethylamino)-anthraquinone
• CAS: 69940-76-7
• 化学式: C₁₆H₁₄N₂O₂
• 分子量: 266.299
• InChiKey: UXFYNFPNBZUUIB-UHFFFAOYSA-N

物化性质

• 熔点：
  146-148 °C
• 沸点：
  517.2±50.0 °C(Predicted)
• 密度：
  1.340±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-aminoethylamino)anthracene-9,10-dione 在 sodium hydroxide 、 sodium hydride 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 34.0h， 生成 1-{2-[1,3-(oxytetraethylenoxy)-3,5,5-tri(phenyloxy-2-carboxaldehyde)cyclotriphosphazatrien-1-yl]aminoethylamino}anthraquinone
  参考文献：
  名称：

  一些新的1,3-（氧四亚乙基氧基）环三磷腈衍生物的合成和体外抗白血病活性。

  摘要：

  具有2-氯乙胺或水杨醛（2-羟基苯甲醛）或其席夫碱（在与2-氯乙胺缩合后）单元并且还具有2-萘基或蒽醌基团作为取代基的一系列新的1,3-（氧四乙氧基）环三磷腈衍生物合成的。已经研究了这些化合物对四种癌细胞系的体外细胞毒性活性。在合成试剂的国际标准（4微克/毫升）的范围内，大多数化合物对选择用于测试的MOLT4，L 1210，HL-60和P388细胞系均具有抗增殖活性。

  DOI：

  10.1021/jm0490078
• 作为产物：
  描述：

  1-氯蒽醌 、 乙二胺 反应 2.0h， 以75%的产率得到1-(2-aminoethylamino)anthracene-9,10-dione
  参考文献：
  名称：

  DNA Intercalators Bearing Metal Chelating Moiety. Ternary Complexes of Polyamine Containing Anthraquinone Derivative-DNA-Cu(II) and Its DNA Cleavage Activity

  摘要：

  与 Cu(II) 和 ds-DNA 连接的多胺 DNA 介导物形成了稳定的三元络合物，其中一些可诱导 ds-DNA 链的裂解。反应活性与配合物的立体化学特征有关。

  DOI：

  10.1246/cl.1994.1053

文献信息

• Symmetrical diazo compounds containing 2-pyridinium groups and a cationic or non-cationic linker, compositions comprising them, method of coloring, and device
  申请人：David Herve

  公开号：US20060156488A1

  公开（公告）日：2006-07-20

  The present disclosure relates to symmetrical cationic diazo compounds of formula (I), the resonance forms, and also the acid addition salts and/or the solvates thereof: The present disclosure further relates to dyeing compositions comprising such compounds as a direct dye in a medium appropriate for the dyeing of keratin fibers, and also to a method of coloring keratin fibers that employs this composition, and a multi-compartment kit containing such compositions.

  本公开涉及公式（I）的对称阳离子重氮化合物，其共振式形式，以及其酸盐和/或溶剂化合物：本公开还涉及包含此类化合物作为直接染料的染料组合物，在适用于染色角蛋白纤维的介质中，以及使用该组合物进行染色角蛋白纤维的方法，以及包含这种组合物的多室套件。
• Pseudo-Dumbbell-Type Molecular Beacon Probes Bearing Modified Deoxyuridine Derivatives and a Silylated Pyrene as a Fluorophore
  作者：Jakir Ahmed Chowdhury、Tomohisa Moriguchi、Kazuo Shinozuka

  DOI：10.1246/bcsj.20140372

  日期：2015.3.15

  We have recently reported a novel pseudo-dumbbell-type molecular beacon probe (Probe 1) possessing polyamine-connected deoxyuridine (U) and silylated pyrene. The probe showed weak fluorescence signal while it stayed alone. Fluorescence signal of the probe was increased in the presence of the complementary DNA. In this study, we prepared new molecular beacons, Probe 2 and Probe 3, possessing the elongated stem portion of Probe 1. In addition, one U in Probe 2 is substituted by anthraquinone-bearing deoxyuridine residue (Y) in Probe 3. Probe 4 is essentially the same as Probe 1 but one deoxyguanosine in the loop portion of Probe 1 is substituted by deoxyinosine in Probe 4. In Probe 5, 3′-terminal deoxycytidine of Probe 3 is substituted by deoxyadenosine. The fluorescence signal of these probes is effectively quenched in the absence of target DNA. Among all, Probe 3 shows the most effective quenching. On the other hand, the signal is substantially increased in the presence of complementary DNA. The ratio of signal to background in case of Probe 3 is the highest. All these probes also recognize single nucleotide alternation in the target DNA to a different extent. The sequence recognition ability of Probe 3 is also the highest among all the probes.

  我们最近报告了一种新型伪哑铃型分子探针（探针1），它由聚胺连接的脱氧尿苷（U）和硅化的芘组成。探针在单独存在时显示出较弱的荧光信号。在存在互补DNA的情况下，探针的荧光信号增强。在本研究中，我们制备了新的分子探针，探针2和探针3，它们具有探针1的延长茎部分。此外，探针2中的一个U被含有蒽醌的脱氧尿苷残基（Y）替代了。在探针4中，基本上与探针1相同，但探针1环部分的一个脱氧鸟苷被探针4中的脱氧次黄嘌呤替代。在探针5中，探针3的3′末端脱氧胞苷被脱氧腺苷替代。这些探针在没有靶DNA的情况下，荧光信号有效淬灭。在所有探针中，探针3的淬灭效果最强。另一方面，在存在互补DNA的情况下，信号显著增强。探针3的信号与背景的比率最高。所有这些探针还以不同程度识别靶DNA中的单核苷酸变异。探针3的序列识别能力在所有探针中也是最高的。
• Cationic diazo compounds, compositions comprising them as direct dye, process for dyeing keratin fibers and device therefor
  申请人：Greaves Andrew

  公开号：US20060005327A1

  公开（公告）日：2006-01-12

  The present disclosure relates to cationic diazo compounds chosen from those of formula (I) and the acid addition salts thereof: Dye1-LK-Dye2 (I); and to dye compositions comprising the the compounds as direct dye, and also to a process for dyeing keratin fibers using this composition and a multi-compartment device.

  本公开涉及选择自式(I)的阳离子重氮化合物及其酸盐：Dye1-LK-Dye2（I）；以及包含这些化合物作为直接染料的染料组合物，还涉及使用该组合物和多室装置染色角蛋白纤维的方法。
• Polycationic monochromophoric hydrazone compounds, dye compositions comprising such polycationic compounds and dyeing process using them
  申请人：David Herve

  公开号：US20080263785A1

  公开（公告）日：2008-10-30

  The present disclosure relates to polycationic monochromophoric hydrazone compounds of following formula (I): wherein W 1 is a heteroaromatic radical comprising 5 or 6 ring members, optionally condensed with an aromatic ring comprising 6 ring members, comprising a quaternized nitrogen atom and optionally another heteroatom which may or may not be identical to nitrogen; X, which may or may not be identical, is a nitrogen atom or a CR 2 group; Z is a cationic group comprising at least one quaternized nitrogen atom. The present disclosure also relates to a composition for dyeing human keratin fibers comprising the polycationic compounds disclosed herein, and to a dyeing process using the composition of the present disclosure, and even further to multicompartment device.

  本公开涉及以下式（I）的多阳离子单色基醛肼化合物： 其中W1是包括5或6个环成员的杂环芳基，可选择地与包括6个环成员的芳香环融合，包括一个季铵化氮原子和可选择的可能与氮不同的另一个杂原子；X，可能相同也可能不同，是一个氮原子或一个CR2基团；Z是包括至少一个季铵化氮原子的阳离子基团。 本公开还涉及一种用于染色人类角蛋白纤维的组合物，包括本公开披露的多阳离子化合物，以及使用本公开的组合物进行染色的过程，甚至进一步涉及多室装置。
• Coloring composition comprising at least one azomethine compound with a pyrazolinone unit
  申请人：Fadli Aziz

  公开号：US20090044348A1

  公开（公告）日：2009-02-19

  The present disclosure relates to a composition for coloring keratin fibers which comprises, in an appropriate dyeing medium, at least one compound chosen from leuco compounds of formula (I), azomethine dyes with a pyrazolinone unit of formula (II), their mesomeric forms, acid addition salts and solvates thereof: and dyeing methods and multicompartment devices for use thereof.

  本公开涉及一种用于染色角蛋白纤维的组合物，该组合物包括至少选自配方(I)的亚亚化合物、配方(II)带有吡唑啉酮单元的偶氮亚甲基染料、它们的共振式形式、酸盐和溶剂化合物，以及用于使用的染色方法和多室装置。