but-3-enoic anhydride | 1760-48-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: but-3-enoic anhydride
• 英文别名: but-3-enoyl but-3-enoate
• CAS: 1760-48-1
• 化学式: C₈H₁₀O₃
• 分子量: 154.166
• InChiKey: OZQBDSLJTSETCK-UHFFFAOYSA-N

物化性质

• 沸点：
  186.8±29.0 °C(Predicted)
• 密度：
  1.018±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  10-Deacetylbaccatine III 、 but-3-enoic anhydride 在 cerium(III) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 20.0h， 以91%的产率得到
  参考文献：
  名称：

  Selective protection of the C(7) and C(10) hydroxyl groups in 10-deacetyl baccatin III

  摘要：

  New protocols for the selective protection of the C(7) and C(10) hydroxyl groups of 10-deacetyl baccatin III are described, leading to more efficient semisyntheses of taxol and taxol analogs. The C(10) hydroxyl group of 10-DAB can be highly selectively acylated or silylated, and subsequent selective protection of the C(7) hydroxyl group then becomes straightforward. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00424-9
• 作为产物：
  描述：

  乙烯基乙酸 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 but-3-enoic anhydride
  参考文献：
  名称：

  酰胺连接到烯烃上的硝酮的分子内环加成

  摘要：

  由相关的酮1-3与N-甲基]-和苄基羟胺原位制备了6个通过酰胺与烯烃连接的硝酮。硝基分子内添加到烯烃中，环加成反应使6-内酰胺4–9立体选择性和区域特异性。化学相关性，CMR光谱和两次X射线晶体学分析确定，六个环加合物4-9的相对立体化学是相同的。

  DOI：

  10.1016/s0040-4020(01)98890-8

文献信息

• Conformationally Driven Two- and Three-Photon Cascade Processes in the Stereoselective Photorearrangement of Pyrroles
  作者：Paul J. Koovits、Jonathan P. Knowles、Kevin I. Booker-Milburn

  DOI：10.1021/acs.orglett.6b02829

  日期：2016.11.4

  A TBSO group has been shown to exert a high degree of stereocontrol during the two-photon photocycloaddition/rearrangement of N-butenylpyrroles to complex tricyclic aziridines. Moreover, this and other bulky groups have been shown to change the outcome of the reaction, promoting a new two-photon sequence to tricyclic imines and an unprecedented stereoselective three-photon sequence to azabicyclo[3

  已显示TBSO基团在N-丁烯基吡咯的二光子光环加成/重排成复杂的三环氮丙啶的过程中具有高度的立体控制。而且，已经表明该基团和其他庞大的基团改变了反应的结果，将新的两光子序列促进为三环亚胺，并将空前的立体选择性三光子序列促进为氮杂双环[3.3.1]壬烷。
• Indium mediated allylation of glyoxylate oxime ethers, esters and cyanoformates
  作者：Dougal J. Ritson、Russell J. Cox、John Berge

  DOI：10.1039/b402764g

  日期：——

  An indium mediated procedure has been developed for the allylation of activated O-functionalised oximes and nitriles as exemplified by a variety of glyoxylate derivatives. This method gives the corresponding free (or protected) amine in a one pot-process. The method is regiospecific and is carried out under remarkably mild conditions so that even oxime esters can be subjected to the typical reaction conditions.

  已开发出一种铟介导的方法，用于活化的O-官能化肟和腈的烯丙基化，如多种甘油酸衍生物的实例所示。该方法可在一步反应中获得相应的自由（或保护）胺。该方法具有区域选择性，并在非常温和的条件下进行，因此即使是肟酯也可以承受典型的反应条件。
• Synthesis and method of purification of cyclic nucleotide derivatives
  申请人：——

  公开号：US20040186282A1

  公开（公告）日：2004-09-23

  The present invention relates to methods for the synthesis and purification of cyclic nucleotide derivatives. The present invention provides a method for separating a cyclic nucleotide derivative from a mixture resulting from a chemical reaction to produce a cyclic nucleotide derivative from a cyclic nucleotide. In one embodiment, this mixture may comprise a cyclic nucleotide derivative, a pyridine solvent, and at least one of an alkyl carboxylic acid, an alkyl acid halide, or an alkyl carboxylic acid anhydride. In another embodiment, this mixture may comprise a cyclic nucleotide derivative and at least one of an alkyl carboxylic acid, an alkyl acid halide, or an alkyl carboxylic acid anhydride.

  本发明涉及用于合成和纯化环核苷酸衍生物的方法。本发明提供了一种从化学反应产生的混合物中分离环核苷酸衍生物的方法，以产生从环核苷酸中得到的环核苷酸衍生物。在一种实施例中，该混合物可能包括环核苷酸衍生物、吡啶溶剂和至少一种烷基羧酸、烷基酸卤或烷基羧酸酐。在另一种实施例中，该混合物可能包括环核苷酸衍生物和至少一种烷基羧酸、烷基酸卤或烷基羧酸酐。
• PRODUCTION OF IONIC LIQUIDS
  申请人：Buchanan Charles Michael

  公开号：US20080194834A1

  公开（公告）日：2008-08-14

  Ionic liquids and processes and apparatus for their production. The ionic liquids can be low sulfur and low halide carboxylated ionic liquids. The ionic liquids can be produced via formation of at least one intermediate carboxylated ionic liquid, and thereafter subjecting the intermediate carboxylated ionic liquid to at least one anion exchange process.

  离子液体及其生产的方法和装置。这些离子液体可以是低硫和低卤代羧酸盐离子液体。这些离子液体可以通过形成至少一种中间羧酸盐离子液体，然后将中间羧酸盐离子液体经过至少一次阴离子交换过程来生产。
• TRIAZINE COMPOUNDS AND PHARMACEUTICAL USE THEREOF
  申请人：Japan Tobacco Inc.

  公开号：US20150266834A1

  公开（公告）日：2015-09-24

  Provided is a compound having an mPGES-1 inhibitory activity and useful for the prophylaxis or treatment of pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma and cancer including colorectal cancer. A compound represented by the formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the SPECIFICATION.

  提供一种具有mPGES-1抑制活性的化合物，可用于预防或治疗疼痛、风湿病、骨关节炎、发热、阿尔茨海默病、多发性硬化症、动脉硬化、青光眼、眼压增高、缺血性视网膜疾病、全身性硬皮病和包括结肠癌在内的癌症。该化合物由式[I]表示，或其药用可接受的盐：其中每个符号如规范中定义。