N-(3-oxobutyl)ellipticinium bromide | 1452593-21-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(3-oxobutyl)ellipticinium bromide
• 英文别名: 1-(5,11-dimethyl-6H-pyrido[4,3-b]carbazol-2-ium-2-yl)propan-2-one;bromide
• CAS: 1452593-21-3
• 化学式: Br*C₂₀H₁₉N₂O
• 分子量: 383.288
• InChiKey: ZWRDXQDSINXMRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.97
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  36.7
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  椭圆玫瑰树碱 、 溴丙酮 以 丙酮 为溶剂， 反应 3.0h， 以85%的产率得到N-(3-oxobutyl)ellipticinium bromide
  参考文献：
  名称：

  Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates

  摘要：

  Polymer conjugates of anticancer drugs have shown high potential for assisting in cancer treatments. The pH-labile spacers allow site-specific triggered release of the drugs. We synthesized and characterized model drug conjugates with hydrazide bond-containing poly[N-(2-hydroxypropyl)methacrylamide] differing in the chemical surrounding of the hydrazone bond-containing spacer to find structure-drug release rate relationships. The conjugate selected for further studies shows negligible drug release in a pH 7.4 buffer but released 50% of the ellipticinium drug within 24 h in a pH 5.0 phosphate saline buffer. The ellipticinium drug retained the antiproliferative activity of the ellipticine. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.07.038

文献信息

• Fine tuning of the pH-dependent drug release rate from polyHPMA-ellipticinium conjugates
  作者：Ondřej Sedláček、Martin Studenovský、David Větvička、Karel Ulbrich、Martin Hrubý

  DOI：10.1016/j.bmc.2013.07.038

  日期：2013.9

  Polymer conjugates of anticancer drugs have shown high potential for assisting in cancer treatments. The pH-labile spacers allow site-specific triggered release of the drugs. We synthesized and characterized model drug conjugates with hydrazide bond-containing poly[N-(2-hydroxypropyl)methacrylamide] differing in the chemical surrounding of the hydrazone bond-containing spacer to find structure-drug release rate relationships. The conjugate selected for further studies shows negligible drug release in a pH 7.4 buffer but released 50% of the ellipticinium drug within 24 h in a pH 5.0 phosphate saline buffer. The ellipticinium drug retained the antiproliferative activity of the ellipticine. (C) 2013 Elsevier Ltd. All rights reserved.