ε-Oximino-capronsaeure-aethylester | 42586-32-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ε-Oximino-capronsaeure-aethylester
• 英文别名: ω-Oximino-capronsaeureethylester；ω-Oximinocapronsaeure-aethylester；Ethyl 6-hydroxyiminohexanoate；ethyl 6-hydroxyiminohexanoate
• CAS: 42586-32-3
• 化学式: C₈H₁₅NO₃
• 分子量: 173.212
• InChiKey: AVXAXOYULPAUQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  58.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ε-Oximino-capronsaeure-aethylester 在 盐酸 、 原甲酸三乙酯 作用下， 生成 5-氰基戊酸乙酯
  参考文献：
  名称：

  New facile method for conversion of oximes to nitriles. Preparation and acid-catalyzed transformation of aldehyde oxime ortho esters

  摘要：

  DOI：

  10.1021/jo00937a030
• 作为产物：
  描述：

  6-氨基己酸乙酯 在 sodium tungstate 、 双氧水 作用下， 生成 ε-Oximino-capronsaeure-aethylester
  参考文献：
  名称：

  Kahr,K.; Berther,C., Chemische Berichte, 1960, vol. 93, p. 132 - 136

  摘要：

  DOI：

文献信息

• Nitrosation in organic chemistry. Nitrosolysis, a novel carbon-carbon bond cleavage effected through nitrosation. Nitrosolysis of ketones and ketone acetals
  作者：Milorad M. Rogic、John Vitrone、Michael D. Swerdloff

  DOI：10.1021/ja00446a031

  日期：1977.2
• Nitrosation in organic chemistry. Nitrosolysis, a novel carbon-carbon bond cleavage effected through nitrosation. Nitrosolysis of ketones
  作者：Milorad M. Rogic、John Vitrone、Michael D. Swerdloff

  DOI：10.1021/ja00846a066

  日期：1975.6
• Isodicyclopentadienes and related molecules. 53. Unsymmetrical oxidative cleavage of cyclic ketones. Conversion to .omega.-ethoxycarbonyl aldoximes under alkaline conditions
  作者：Cornelis M. Moorhoff、Leo A. Paquette

  DOI：10.1021/jo00002a040

  日期：1991.1

  A useful procedure for effecting the direct unsymmetrical cleavage of an enolizable cyclic ketone to an oximino ester has been developed. The process begins by deprotonation with LDA and is followed by the addition of ethyl nitrite in THF at low temperature. Rapid reaction customarily ensues with resultant overall nitrosolysis. Of particular importance is the facile application of this procedure to substrate ketones that are otherwise sensitive to acidic environments. This feature is exemplified in particular in the case of syn- and anti-sesquinorbornenones 34 and 35, access to which is described for the first time. Since the entire process is executed in a single flask, the methodology is very convenient to implement in practice.
• Kahr,K.; Berther,C., Chemische Berichte, 1960, vol. 93, p. 132 - 136
  作者：Kahr,K.、Berther,C.

  DOI：——

  日期：——
• New facile method for conversion of oximes to nitriles. Preparation and acid-catalyzed transformation of aldehyde oxime ortho esters
  作者：Milorad M. Rogic、Jan F. Van Peppen、Karl P. Klein、Timothy R. Demmin

  DOI：10.1021/jo00937a030

  日期：1974.11