4-methylhistamine | 27796-42-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-methylhistamine
• 英文别名: 4-methyl-5-propyl-1(3)H-imidazole；4-Methyl-5-propyl-1(3)H-imidazol；5-Propyl-4-methylimidazol；5-methyl-4-propyl-1H-imidazole
• CAS: 27796-42-5
• 化学式: C₇H₁₂N₂
• mdl: MFCD19218907
• 分子量: 124.186
• InChiKey: DMMJOFFEWKZGST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 亚硝酸乙酯 作用下， 生成 4-methylhistamine
  参考文献：
  名称：

  Kuenne, Chemische Berichte, 1895, vol. 28, p. 2043

  摘要：

  DOI：

文献信息

• Syntheses of polyalkylated imidazoles
  作者：Sigvart Evjen、Anne Fiksdahl

  DOI：10.1080/00397911.2017.1330416

  日期：2017.8.3

  ABSTRACT We have developed improved general simple methods for large-scale preparation of polyalkylated imidazoles by improved multicomponent synthesis from commercially available starting materials. A large range of NH- and N-alkyl-polyalkylimidazoles (40 in total, including novel compounds) has been synthesized. GRAPHICAL ABSTRACT

  摘要我们已经开发了改进的通用简单方法，通过改进的多组分合成从市售原料大规模制备聚烷基化咪唑。已经合成了多种 NH-和 N-烷基-聚烷基咪唑（共 40 种，包括新型化合物）。图形概要
• Nicotinamide Derivatives
  申请人：Blake Tanisha D.

  公开号：US20080146569A1

  公开（公告）日：2008-06-19

  The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein the substituents are as defined herein, compositions containing such compounds and the uses of such compounds for the treatment of various diseases and conditions such as asthma.

  本发明涉及公式（I）的化合物及其药用可接受的盐和溶剂化合物，其中取代基如本文所定义，包含这种化合物的组合物以及这种化合物用于治疗各种疾病和状况，如哮喘。
• CXCR4 receptor antagonists
  申请人：Proximagen, LLC

  公开号：US10995091B2

  公开（公告）日：2021-05-04

  The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.

  式（I）化合物是 CXCR4 受体的拮抗剂 其中 R1、X、Y 和 R2 如权利要求中所定义。
• BRIDGED PIPERIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS
  申请人：Merck & Co., Inc.

  公开号：EP1411940B1

  公开（公告）日：2008-10-15
• METHODS AND COMPOSITIONS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION
  申请人：Choong Ingrid C.

  公开号：US20120276050A1

  公开（公告）日：2012-11-01

  Clemizole and clemizole analog compounds, and pharmaceutical compositions of the same, are useful in methods of treating a host infected with a virus from the Flaviviridae family of viruses, methods of inhibiting HCV replication in a host, methods of inhibiting the binding of NS4B polypeptide to the 3′UTR of HCV negative strand RNA in a host, and methods of treating liver fibrosis in a host.