clindamycin hydrochloride monohydrate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: clindamycin hydrochloride monohydrate
• 英文别名: (2S,4R)-2-(N-{(1S,2S)-2-chloro-1-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)perhydropyran-2-yl]propyl}aminocarbonyl)-4-propylpyrrolidinium chloride monohydrate；(2S,4R)-N-[(1S,2S)-2-chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidin-1-ium-2-carboxamide;chloride;hydrate
• 化学式: C₁₈H₃₃ClN₂O₅S*ClH*H₂O
• 分子量: 479.466
• InChiKey: KWMXKEGEOADCEQ-WNNJHRBUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.01
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  129
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  clindamycin hydrochloride monohydrate 以95的产率得到Clindamycin 3,4-isopropylidene
  参考文献：
  名称：

  一种克林霉素磷酸酯的制备方法

  摘要：

  本发明属于化学合成技术领域，涉及一种克林霉素磷酸酯的制备方法。本发明的方法以盐酸克林霉素醇化物为原料制备克林霉素异丙叉碱，再以三氯氧磷为磷酯化剂、1,2,4‑三氮唑作缚酸剂，发生磷酯化反应，得异丙叉克林霉素磷酸酯，最后经混合酸水解脱保护得克林霉素磷酸酯。本发明的方法通过有机酸水解一步法制备克林霉素磷酸酯，该方法节能环保，所得克林霉素磷酸酯的收率高、纯度好、成本低，能直接得到成品，无须后续再对产品进行精制，使得克林霉素磷酸酯的摩尔收率可达96.15％，且产品晶型好(堆密度、流动性)，非常有利于无菌分装。

  公开号：

  CN107652332A
• 作为产物：
  描述：

  盐酸林可霉素 以 水 为溶剂， 以86%的产率得到clindamycin hydrochloride monohydrate
  参考文献：
  名称：

  Synthesis of 7-halo-7-deoxylincomycins

  摘要：

  一种改进的制备7-卤代-7-去氧林可霉素及其类似物的工艺。制备出的化合物具有抗菌活性。

  公开号：

  US04568741A1

文献信息

• MULTIFUNCTIONAL (METH)ACRYLATE MANUFACTURING METHOD
  申请人：TOAGOSEI CO., LTD.

  公开号：US20170204044A1

  公开（公告）日：2017-07-20

  [Problem] The purpose of the present invention is to obtain a multifunctional (meth)acrylate with good yield by an ester exchange reaction of a polyhydric alcohol such as pentaerythritol or dipentaerythritol with a monofunctional (meth)acrylate. [Solution] A multifunctional (meth)acrylate manufacturing method characterized in that when manufacturing a multifunctional (meth)acrylate by an ester exchange reaction of a polyhydric alcohol with a monofunctional (meth)acrylate, catalyst (A) and catalyst (B) are used together. Catalyst (A): One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure or salts or complexes thereof, amidines or salts or complexes thereof, and compounds with a pyridine ring or salts or complexes thereof. Catalyst (B): One or more kinds of compounds selected from a group consisting of zinc-containing compounds.

  [问题] 本发明的目的是通过多元醇（如戊三醇或二戊三醇）与单官能基（甲基）丙烯酸酯的酯交换反应，获得产率高的多功能（甲基）丙烯酸酯。[解决方案] 一种多功能（甲基）丙烯酸酯制备方法，其特征在于，在通过多元醇与单官能基（甲基）丙烯酸酯的酯交换反应制备多功能（甲基）丙烯酸酯时，同时使用催化剂（A）和催化剂（B）。催化剂（A）：选自具有氮杂双环结构的环三胺或其盐或络合物、酰胺或其盐或络合物以及吡啶环或其盐或络合物组成的群中的一种或多种化合物。催化剂（B）：选自含锌化合物组成的群中的一种或多种化合物。
• Preparing clindamycin and analogues thereof
  申请人：THE UPJOHN COMPANY

  公开号：EP0161794A2

  公开（公告）日：1985-11-21

  A process for preparing 7-halo-7-deoxylincomycin or an analogue thereof, which comprises (a) reacting a starting compound selected from lincomycin and analogues thereof, with an amide halide having the formula wherein each Hal is bromine or chlorine, and either Ri and R2 are independently selected from aryl and C1-8 alkyl or NR1R2 is morpholino or a heterocyclic ring containing 4 to 8 ring atoms selected from carbon and nitrogen, to form an adduct; (b) heating the adduct, to form a 7-halo-7-deoxy adduct; and (c) hydrolysing the 7-halo-7-deoxy adduct with an aqueous base.

  一种制备 7-卤代-7-脱氧辛霉素或其类似物的工艺，包括 (a) 将选自林可霉素及其类似物的起始化合物与酰胺卤化物反应，酰胺卤化物的 式为 其中每个 Hal 是溴或氯，Ri 和 R2 独立地选自芳基和 C1-8 烷基，或 NR1R2 是吗啉基或含有 4 至 8 个选自碳和氮的环原子的杂环，以形成加合物； (b) 加热加合物，形成 7-卤代-7-脱氧加合物；和 (c) 用水基水解 7-卤代-7-脱氧加合物。
• Preparing 7-halo-7-deoxylincomycins
  申请人：THE UPJOHN COMPANY

  公开号：EP0183505A2

  公开（公告）日：1986-06-04

  A process for preparing a 7-halodeoxylincomycin or an analogue thereof, which comprises reacting lincomycin or an analogue thereof with a thionyl halide and dimethylformamide, under mild conditions.

  一种制备 7-卤代乙酰林可霉素或其类似物的工艺，包括在温和条件下使林可霉素或其类似物与亚硫酰卤和二甲基甲酰胺反应。
• Multifunctional (meth)acrylate manufacturing method
  申请人：TOAGOSEI CO., LTD.

  公开号：US10035752B2

  公开（公告）日：2018-07-31

  [Problem] The purpose of the present invention is to obtain a multifunctional (meth)acrylate with good yield by an ester exchange reaction of a polyhydric alcohol such as pentaerythritol or dipentaerythritol with a monofunctional (meth)acrylate. [Solution] A multifunctional (meth)acrylate manufacturing method characterized in that when manufacturing a multifunctional (meth)acrylate by an ester exchange reaction of a polyhydric alcohol with a monofunctional (meth)acrylate, catalyst (A) and catalyst (B) are used together. Catalyst (A): One or more kinds of compounds selected from a group consisting of cyclic tertiary amines with an azabicyclo structure or salts or complexes thereof, amidines or salts or complexes thereof, and compounds with a pyridine ring or salts or complexes thereof. Catalyst (B): One or more kinds of compounds selected from a group consisting of zinc-containing compounds.

  [问题]本发明的目的是通过季戊四醇或季戊四醇等多元醇与单官能团（甲基）丙烯酸酯的酯交换反应，获得收率高的多官能团（甲基）丙烯酸酯。 [解]一种多功能（甲基）丙烯酸酯的制造方法，其特征在于通过多元醇与单官能（甲基）丙烯酸酯的酯交换反应制造多功能（甲基）丙烯酸酯时，催化剂（A）和催化剂（B）一起使用。催化剂 (A)：一种或多种化合物，选自具有氮杂双环结构的环状叔胺或其盐或络合物、脒或其盐或络合物以及具有吡啶环的化合物或其盐或络合物组成的组。催化剂 (B)：一种或多种选自含锌化合物组的化合物。
• Curable composition
  申请人：TOAGOSEI CO., LTD.

  公开号：US10611856B2

  公开（公告）日：2020-04-07

  Provided is a method for making a curable composition that has low viscosity and rapid curing ability in the form of thin film, further has excellent resistance to emulsification and preservation stability, and has high hardness in the form of cured film, thereby achieving excellent alkali developability, which is preferably an active energy beam-curable composition, is provided. The made curable composition includes a mixture (A) of a compound having two or more (meth)acryloyl groups, and is obtained by conducting a transesterification reaction of diglycerin and/or glycerin and a compound having one (meth)acryloyl group under the presence of the following catalysts X and Y: catalyst X: a compound that is at least one member selected from the group consisting of cyclic tertiary amine having an azabicyclo structure or a salt or complex thereof, amidine or a salt or complex thereof, and a compound having a pyridine ring or a salt or complex thereof; and catalyst Y: a compound including zinc.

  本发明提供了一种固化组合物的制造方法，该固化组合物以薄膜的形式具有低粘度和快速固化能力，进一步具有优异的抗乳化性和保存稳定性，以固化薄膜的形式具有高硬度，从而实现优异的碱显影性，该固化组合物优选为活性能量束固化组合物。制成的可固化组合物包括具有两个或两个以上（甲基）丙烯酰基的化合物的混合物 (A)，该混合物是在以下催化剂 X 和 Y 的存在下，通过二甘油和/或甘油与具有一个（甲基）丙烯酰基的化合物进行酯交换反应而得到的：催化剂 X：至少一种选自以下组别的化合物：具有氮杂双环结构的环状叔胺或其盐或络合物、脒或其盐或络合物、具有吡啶环的化合物或其盐或络合物；以及催化剂 Y：包括锌的化合物。