α-isobutyric acid methyl ester | 135765-47-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: α-isobutyric acid methyl ester
• 英文别名: methyl 2-[(2-chloro-2-methylpropyl)-methoxyamino]-2-methylpropanoate
• CAS: 135765-47-8
• 化学式: C₁₀H₂₀ClNO₃
• 分子量: 237.727
• InChiKey: IZYJEXOBMFVWTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.82
• 重原子数：
  15.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  38.77
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  methyl ester of α-(N-chloro-N-methoxyamino)isobutyric acid 在 二氧化硫 、 异丁烯 作用下， 以26%的产率得到α-isobutyric acid methyl ester
  参考文献：
  名称：

  Reactions of N-chloro-N-alkoxy-tert-alkylamines with isobutylene and methanol

  摘要：

  The addition of N-chloro-N-methoxy-tert-alkylamines to an olefin, which is assumed to proceed with the participation of alkoxynitrenium ions, was carried out for the first time. The methanolysis of N-chloro-N-alkoxy-tert-alkylamines in the presence of Et3N gives dialkoxyamines, and depending on the type of the N-alkyl substituent is accompanied by side reactions.

  DOI：

  10.1007/bf00961356

文献信息

• SHTAMBURG, V. G.;RUDCHENKO, V. F.;GRINEV, V. M.;DMITRENKO, A. A.;PLESHKOV+, IZV. AN CCCP. CEP. XIM.,(1991) N, S. 1069-1072
  作者：SHTAMBURG, V. G.、RUDCHENKO, V. F.、GRINEV, V. M.、DMITRENKO, A. A.、PLESHKOV+

  DOI：——

  日期：——
• Reactions of N-chloro-N-alkoxy-tert-alkylamines with isobutylene and methanol
  作者：V. G. Shtamburg、V. F. Rudchenko、V. M. Grinev、A. A. Dmitrenko、A. P. Pleshkova、R. G. Kostyanovskii

  DOI：10.1007/bf00961356

  日期：1991.5

  The addition of N-chloro-N-methoxy-tert-alkylamines to an olefin, which is assumed to proceed with the participation of alkoxynitrenium ions, was carried out for the first time. The methanolysis of N-chloro-N-alkoxy-tert-alkylamines in the presence of Et3N gives dialkoxyamines, and depending on the type of the N-alkyl substituent is accompanied by side reactions.