2-[5-(1-Adamantylmethoxy)pentyl]propanedioic acid | 1352410-94-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-[5-(1-Adamantylmethoxy)pentyl]propanedioic acid
• CAS: 1352410-94-6
• 化学式: C₁₉H₃₀O₅
• 分子量: 338.444
• InChiKey: XNPYHGURKAPSHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[5-(1-Adamantylmethoxy)pentyl]propanedioic acid 在 盐酸 作用下， 以 水 为溶剂， 反应 72.0h， 生成 7-(1-Adamantylmethoxy)heptanoic acid
  参考文献：
  名称：

  NON-AMPHIPHILE-BASED WATER-IN-WATER EMULSION AND USES THEREOF

  摘要：

  本发明涉及一种非两亲性基材的水包水乳液组合物。该非两亲性基材的水包水乳液组合物包括水溶性聚合物、被水溶性聚合物封装的非两亲性溶致液晶；和水。在一个实施例中，非两亲性溶致液晶包括但不限于溶致色浆液晶，更具体地是无钠 Cromoglicate (DSCG)。在另一个实施例中，水溶性聚合物可以包括但不限于聚丙烯酰胺、聚醇、聚乙烯吡咯烷酮、多糖或水溶性含氟聚合物。本发明还涉及一种用非两亲性基材的水包水乳液制成的多孔水凝胶。本发明进一步涉及使用该乳液和水凝胶用于各种应用。

  公开号：

  US20090269323A1
• 作为产物：
  描述：

  Diethyl 2-[5-(1-adamantylmethoxy)pentyl]propanedioate 在 sodium hydroxide 作用下， 以 水 为溶剂， 以83%的产率得到2-[5-(1-Adamantylmethoxy)pentyl]propanedioic acid
  参考文献：
  名称：

  NON-AMPHIPHILE-BASED WATER-IN-WATER EMULSION AND USES THEREOF

  摘要：

  本发明涉及一种非两亲性基材的水包水乳液组合物。该非两亲性基材的水包水乳液组合物包括水溶性聚合物、被水溶性聚合物封装的非两亲性溶致液晶；和水。在一个实施例中，非两亲性溶致液晶包括但不限于溶致色浆液晶，更具体地是无钠 Cromoglicate (DSCG)。在另一个实施例中，水溶性聚合物可以包括但不限于聚丙烯酰胺、聚醇、聚乙烯吡咯烷酮、多糖或水溶性含氟聚合物。本发明还涉及一种用非两亲性基材的水包水乳液制成的多孔水凝胶。本发明进一步涉及使用该乳液和水凝胶用于各种应用。

  公开号：

  US20090269323A1

文献信息

• Adamantane–platinum conjugate hosted in β-cyclodextrin: Enhancing transport and cytotoxicity by noncovalent modification
  作者：Deepali Prashar、Yi Shi、Debjyoti Bandyopadhyay、James C. Dabrowiak、Yan-Yeung Luk

  DOI：10.1016/j.bmcl.2011.10.006

  日期：2011.12

  This work reports the synthesis of a complex of a carboplatin analog having tethered adamantane that is encapsulated in the hydrophobic cavity of beta-cyclodextrin (beta CD) and its cytotoxic activity towards human neuroblastoma cells (SK-N-SH). We found that this inclusion complex of bCD adamantane carboplatin analog exhibited higher cytotoxicity towards SK-N-SH cells than carboplatin itself, and the inclusion complex exhibited a higher binding to plasmid pBR322 deoxyribonucleic acid (DNA) than carboplatin. Confocal fluorescence images of SK-N-SH cells treated with beta CD having an attached fluorescein isothiocyanate (FITC)-tag exhibited fluorescence in the vicinity of the nuclei of the neuroblastoma cells. Direct measurements of the platinum content in SK-N-SH cells using inductively coupled plasma mass spectrometry (ICP-MS) indicated that the uptake rate of carboplatin was about 4 times higher than beta CD adamantane carboplatin analog inclusion complex. When compared to carboplatin, we believe that the higher cytotoxicity of inclusion complex towards SK-N-SH cells is due to its higher DNA binding ability as compared to carboplatin, and more efficient delivery to the nucleus of the cell. This work suggests that the advantage of deliberate noncovalent modification with beta CD through host-guest chemistry may also be broadly applicable to other anticancer agents as well. (C) 2011 Elsevier Ltd. All rights reserved.
• US9150788B2
  申请人：——

  公开号：US9150788B2

  公开（公告）日：2015-10-06
• NON-AMPHIPHILE-BASED WATER-IN-WATER EMULSION AND USES THEREOF
  申请人：LUK Yan-Yeung

  公开号：US20090269323A1

  公开（公告）日：2009-10-29

  The present invention relates to a non-amphiphile-based water-in-water emulsion composition. The non-amphiphile-based water-in-water emulsion composition includes a water-soluble polymer, a non-amphiphilic lyotropic mesogen encapsulated by the water-soluble polymer; and water. In one embodiment, the non-amphiphilic lyotropic mesogen includes, without limitation, a lyotropic chromonic liquid crystal, and more specifically disodium cromoglycate (DSCG). In another embodiment, the water-soluble polymer can include, without limitation, a polyacrylamide, a polyol, a polyvinylpyrrolidone, a polysaccharide, or a water-soluble fluoride-bearing polymer. The present invention also relates to a porous hydrogel made with the use of the non-amphiphile-based water-in-water emulsion. The present invention further relates to using the emulsion and hydrogel for various applications.

  本发明涉及一种非两亲性基材的水包水乳液组合物。该非两亲性基材的水包水乳液组合物包括水溶性聚合物、被水溶性聚合物封装的非两亲性溶致液晶；和水。在一个实施例中，非两亲性溶致液晶包括但不限于溶致色浆液晶，更具体地是无钠 Cromoglicate (DSCG)。在另一个实施例中，水溶性聚合物可以包括但不限于聚丙烯酰胺、聚醇、聚乙烯吡咯烷酮、多糖或水溶性含氟聚合物。本发明还涉及一种用非两亲性基材的水包水乳液制成的多孔水凝胶。本发明进一步涉及使用该乳液和水凝胶用于各种应用。