4-Methylpentyl 3,4,5-trihydroxybenzoate | 1026229-21-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Methylpentyl 3,4,5-trihydroxybenzoate
• CAS: 1026229-21-9
• 化学式: C₁₃H₁₈O₅
• 分子量: 254.283
• InChiKey: GQQHYDOASGECII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-甲基-1-戊醇 、 没食子酸 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 4-Methylpentyl 3,4,5-trihydroxybenzoate
  参考文献：
  名称：

  Antifungal activity of alkyl gallates against plant pathogenic fungi

  摘要：

  The antifungal activity of alkyl gallates against plant pathogenic fungi was evaluated. All of the fungi tested in this study were susceptible to some alkyl gallates, and the effect of linear alkyl gallates against plant pathogenic fungi was similar to the previously reported effects against Gram-negative and Gram-positive bacteria. We found that branched alkyl gallates showed stronger activity than did linear alkyl gallates with similar log P values. In addition, the antifungal activity of alkyl gallates was correlated with gallate-induced inhibition of the activity of mitochondrial complex II. The antifungal activity of alkyl gallates likely originates, at least in part, from their ability to inhibit the membrane respiratory chain. (c) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.02.017

文献信息

• METHOD FOR MEASURING ACTIVATED PARTIAL THROMBOPLASTIN TIME AND REAGENT KIT FOR ACTIVATED PARTIAL THROMBOPLASTIN TIME MEASUREMENT
  申请人：SYSMEX CORPORATION

  公开号：EP3798635A1

  公开（公告）日：2021-03-31

  Disclosed is a method for measuring activated partial thromboplastin time, the method comprising: mixing: a blood sample; a first reagent comprising an ellagic acid compound and a compound represented by Formula (I); and a second reagent comprising a calcium ion; and measuring activated partial thromboplastin time using the mixture prepared in the mixing step, wherein the compound represented by Formula (I) is shown below wherein X is a hydrogen atom, -(C=O)-Y, or -(C=O)-OZ, Y is a hydroxyl group, a hydrogen atom, a linear or branched alkyl group having a carbon number of 1 or more and 6 or less, or a phenyl group, and Z is an alkali metal.

  公开了一种测量活化部分凝血活酶时间的方法，该方法包括：混合：血液样本；第一试剂，包括鞣花酸化合物和由式（I）代表的化合物；以及第二试剂，包括钙离子；以及使用混合步骤中制备的混合物测量活化部分凝血活酶时间，其中由式（I）代表的化合物如下所示 其中 X 是氢原子、-(C=O)-Y 或 -(C=O)-OZ，Y 是羟基、氢原子、碳数为 1 或 1 以上 6 或以下的直链或支链烷基或苯基，Z 是碱金属。
• COMPOSITIONS COMPRISING S-ADENOSYLMETHIONINE AND A GALLIC ACID ESTER
  申请人：Methylation Sciences International SRL

  公开号：EP2753336B1

  公开（公告）日：2015-05-06
• NOVEL ADEMETIONINE FORMULATIONS
  申请人：Methylation Sciences International SRL

  公开号：EP3131557A2

  公开（公告）日：2017-02-22
• Compositions Comprising S-Adenosylmethionine and a Gallic Acid Ester
  申请人：Methylation Sciences International SRL

  公开号：US20140220129A1

  公开（公告）日：2014-08-07

  Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.
• Compositions comprising S-Adenosylmethionine and a gallic acid ester
  申请人：Methylation Sciences International SRL

  公开号：US20190022119A1

  公开（公告）日：2019-01-24

  Provided herein are compositions and formulations comprising S-adenosyl-L-methionine (“SAM-e” or “SAMe”) and one or more gallic acid esters. Also provided herein are methods for improving the delivery of SAMe. Compositions and formulations provided herein increase SAMe plasma concentrations and area under the curve (AUC) values. Also provided herein are methods of treating a disease or disorder in a subject by administering compositions or formulations comprising exogenous SAMe and one or more gallic acid esters.