N-Pentadecyl-acrylamide | 132102-07-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-Pentadecyl-acrylamide
• 英文别名: N-pentadecylprop-2-enamide
• CAS: 132102-07-9
• 化学式: C₁₈H₃₅NO
• 分子量: 281.482
• InChiKey: IDCPRXXDMHJHRU-UHFFFAOYSA-N

物化性质

• 沸点：
  416.9±18.0 °C(Predicted)
• 密度：
  0.861±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-Pentadecyl-acrylamide 、 β-丙氨酸 在 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 12.0h， 以49%的产率得到3-(2-Pentadecylcarbamoyl-ethylamino)-propionic acid
  参考文献：
  名称：

  Allikmaa, V. O.; Kuusk, A. E., Journal of applied chemistry of the USSR, 1989, vol. 62, # 22, p. 322 - 326

  摘要：

  DOI：

文献信息

• Amine-containing lipids and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：EP2476756A1

  公开（公告）日：2012-07-18

  Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

  本文介绍了通过胺与丙烯酸酯、丙烯酰胺或其他与电子萃取基团共轭的碳碳双键的共轭加成制备含氮脂质的方法。此外，还提供了利用市售起始材料制备这些脂质的方法。这些含胺脂质或其盐类最好具有生物降解性和生物相容性，可用于各种给药系统。考虑到这些脂质的氨基，它们特别适用于多核苷酸的递送。已制备出含有本发明脂质和多核苷酸的复合物或纳米颗粒。本发明脂质还可用于制备给药微粒。由于本发明脂质具有缓冲周围环境 pH 值的能力，因此特别适用于递送易溶剂。
• OPTICAL FIBRE COATING WITH NON-RADIATION-CURABLE ACRYLIC HARD-SOFT BLOCK COPOLYMER
  申请人：Corning Inc.

  公开号：EP3092277A2

  公开（公告）日：2016-11-16
• THERAPEUTIC COMPOSITIONS
  申请人：Tzianabos Arthur

  公开号：US20110052673A1

  公开（公告）日：2011-03-03

  Therapeutic compositions containing therapeutic agents and nitrogen-containing lipids are described. These tertiary amine-containing polymers are preferably biodegradable and biocompatible. Nanoparticles, microparticles, and complexes containing lipid/therapeutic agent complexes are also described.
• US20140341524A1
  申请人：——

  公开号：US20140341524A1

  公开（公告）日：2014-11-20
• METHOD FOR PRODUCING RESIN COMPOSITION AND RESIN COMPOSITION
  申请人：CANON KABUSHIKI KAISHA

  公开号：US20140323659A1

  公开（公告）日：2014-10-30

  A method for producing a resin composition, comprising the step of: subjecting a radical copolymerization of a first radical polymerizable monomer which is free from any crystalline molecular chain, and a second radical polymerizable monomer having a crystalline molecular chain, in the presence of a radical polymerization initiator, wherein the second radical polymerizable monomer is the following compound, and (wherein R 1 denotes a hydrogen atom or a methyl group, and R 2 denotes an alkyl group having at least 17 carbon atoms) the first radical polymerizable monomer has a particular reactivity ratio.