tris[2-(4-formylphenoxy)ethyl]amine | 153897-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: tris[2-(4-formylphenoxy)ethyl]amine
• 英文别名: 2,2',2''-tris[(4-formylphenoxy)ethyl]amine；4-[2-[Bis[2-(4-formylphenoxy)ethyl]amino]ethoxy]benzaldehyde；4-[2-[bis[2-(4-formylphenoxy)ethyl]amino]ethoxy]benzaldehyde
• CAS: 153897-40-6
• 化学式: C₂₇H₂₇NO₆
• 分子量: 461.514
• InChiKey: FNCVPGIEAVLKGT-UHFFFAOYSA-N

物化性质

• 熔点：
  80-82 °C
• 沸点：
  660.0±55.0 °C(Predicted)
• 密度：
  1.230±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  34
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  82.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  tris[2-(4-formylphenoxy)ethyl]amine 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 20.0h， 生成 tris{2-[4-(N-methylamino)methylphenoxy]ethyl}amine
  参考文献：
  名称：

  A Self-Assembled Multivalent Pseudopolyrotaxane for Binding Galectin-1

  摘要：

  A self-assembled pseudopolyrotaxane consisting of lactoside-displaying cyclodextrin (CD) "beads" threaded onto a linear polyviologen "string" was investigated for its ability to inhibit galectin-1-mediated T-cell agglutination. The CDs of the pseudopolyrotaxane are able to spin around the axis of the polymer chain as well as to move back and forth along its backbone to alter the presentation of its ligand. This supramolecular superstructure incorporates all the advantages of polymeric structures, such as the ability to span large distances, along with a distinctively dynamic presentation of its lactoside ligands to afford a neoglycoconjugate that can adjust to the relative stereochemistries of the lectin's binding sites. The pseudopolyrotaxane exhibited a valency-corrected 10-fold enhancement over native lactose in the agglutination assay, which was greater than the enhancements observed for lactoside-bearing trivalent glycoclusters and a lactoside-bearing chitosan polymer tested using the same assay. The experimental results indicate that supramolecular architectures, such as the pseudo polyrotaxane, provide tools for investigating protein-carbohydrate interactions.

  DOI：

  10.1021/ja0491073
• 作为产物：
  描述：

  三(2-氯乙基)胺盐酸盐 、 对羟基苯甲醛 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以75%的产率得到tris[2-(4-formylphenoxy)ethyl]amine
  参考文献：
  名称：

  以Cs（I）离子为模板通过[2 + 3] Schiff碱缩合合成具有三位受体位点的穴状配体

  摘要：

  据报道，通过[2 + 3]三醛1或2与1,2-二氨基苯的席夫碱缩合，然后用NaBH 4还原，可以合成两个三位受体L 1和L 2。在以Cs（I）离子为模板的情况下，反应平稳进行。

  DOI：

  10.1016/s0040-4039(00)73901-3

文献信息

• Study of electronic and vibronic contributions to cooperative enhancement of two-photon absorption in multibranched structures
  作者：Jianqiang Xue、Yuxia Zhao、Jie Wu、Feipeng Wu、Xiangyun Fang

  DOI：10.1039/b814013h

  日期：——

  synthesized. Their one- and two-photon photophysical properties were systematically studied in comparison with corresponding triphenylamine derivatives. Electronic coupling and vibronic coupling contributions to cooperative enhancement of two-photon absorption in multibranched structure were revealed. The results showed that the crucial contribution for this enhancement was from electronic coupling effect among

  一系列多支 亚苄基环戊酮合成具有非共轭中心部分的染料。与相应的三苯胺衍生物比较，系统地研究了它们的一光子和二光子光物理性质。揭示了电子耦合和振动耦合对多支化结构中双光子吸收协同增强的贡献。结果表明，这种增强的关键贡献来自分支之间的电子耦合效应。另外，未观察到振动耦合的贡献。此外，通过单光子聚合研究了这些化合物对光敏效率的多支化效应，结果表明电子偶联效应也有利于它们的光敏效率。
• Preparation, spectroscopic, and electrochemical properties of four novel trinuclear Ru(II) polypyridyl complexes containing diazafluorene
  作者：Feixiang Cheng、Ning Tang、Jishu Chen、Longhai Chen、Lei Jia、Guang Chen

  DOI：10.1016/j.inoche.2009.11.025

  日期：2010.2

  Abstract Four tripodal ligands 2,2′,2″-tris[4-(4,5-diazafluoren-9-ylhydrazinyl)methylenephenoxyethyl]amine (L1), 1,1,1-tris[4-(4,5-diazafluoren-9-ylhydrazinyl)methylenephenoxymethyl]propane (L2), 1,3,5-tris[4-(4,5-diazafluoren-9-ylhydrazinyl)methylenephenoxymethyl]-2,4,6-trimethylbenzene (L3), 1,3,5-tris[4-(4,5-diazafluoren-9-ylhydrazinyl)methylenephenoxymethyl]benzene (L4), and corresponding Ru(II)

  摘要 四种三足配体 2,2',2"-三[4-(4,5-二氮杂芴-9-基肼基)亚甲基苯氧基乙基]胺 (L1), 1,1,1-三[4-(4,5-二氮杂芴) -9-基肼基)亚甲基苯氧基甲基]丙烷 (L2), 1,3,5-三[4-(4,5-二氮杂芴-9-基肼基)亚甲基苯氧基甲基]-2,4,6-三甲基苯 (L3), 1,3 ,5-三[4-(4,5-二氮杂芴-9-基肼基)亚甲基苯氧基甲基]苯 (L4) 和相应的 Ru(II) 配合物 [(bpy)6L1–4(RuII)3](PF6)6 (Ru -L1-4) 已合成。这些配合物的循环伏安法包括一个以 Ru(II) 为中心的可逆氧化和三个以配体为中心的还原。通过紫外-可见吸收和发光光谱研究光物理行为。这些配合物在约 410 nm 处显示金属到配体的电荷转移吸收，并在约 582 nm 处发射。
• The crystal structure of N5O3 cryptand
  作者：L.-X. Pan、B. Zhang、Y. Su、Z. Ma

  DOI：10.1134/s0022476617030258

  日期：2017.5

  KBH4. There are six unique molecules in the unit. The molecule has a threefold symmetry axis passing through the bridgehead nitrogen atoms in the structure. As a result, only one strand of the cryptand molecule is present in the asymmetric unit. The structure presents an endoendo conformation, with the distance between the two bridgehead nitrogen atoms of 10.030(8) Å.

  标题化合物 1,4,13,22,27-pentaaza-6,9:17,20:29,32-tribenzo-10,16,33-trioxabicyclo[11,11,11]pentatricontane (C33H45N5O3) 是在La(NO3)3·6H2O作为模板剂存在下，通过三醛(4,4′,4″-三甲酰基-三苯氧基三乙胺)与三(2-氨基乙基)胺(tren)的[1+1]三足缩合合成，然后用 KBH4 还原。该单元中有六个独特的分子。该分子具有穿过结构中桥头氮原子的三重对称轴。结果，在不对称单元中仅存在隐窝分子的一条链。该结构呈现内内构象，两个桥头氮原子之间的距离为 10.030(8) Å。
• Designing dendrimers for ocular drug delivery
  作者：Grégory Spataro、François Malecaze、Cédric-Olivier Turrin、Vincent Soler、Carine Duhayon、Pierre-Paul Elena、Jean-Pierre Majoral、Anne-Marie Caminade

  DOI：10.1016/j.ejmech.2009.10.017

  日期：2010.1

  New series of phosphorus-containing dendrimers, having one quaternary ammonium salt as core and carboxylic acid terminal groups have been synthesized from generation 0 (3 carboxylic acid terminal groups) to generation 2 (12 carboxylic acid terminal groups). These dendrimers react with the neutral form of carteolol (an ocular anti-hypertensive drug used to treat glaucoma) to afford ion pair (saline) species. The solubility in water of these charged dendrimers depends on the generation considered: generation 0 (3 carteolol) is well soluble, whereas generation 1 (6 carteolol) and generation 2 (12 carteolol) are poorly soluble. These dendrimers have been tested in vivo, as vehicle for ocular drug delivery of carteolol to rabbits. (C) 2009 Elsevier Masson SAS. All rights reserved.
• Toward dynamic combinatorial libraries of cryptands
  作者：Krzysztof Ziach、Magdalena Ceborska、Janusz Jurczak

  DOI：10.1016/j.tetlet.2011.06.075

  日期：2011.8

  The first examples of dynamic combinatorial libraries of cryptands, created using the chemistry of imines is presented. Experiments, in which two trialdehydes compete for one triamine in a small library, show the full reversibility of cryptand formation, since the library composition is the same irrespective of the sequence of introducing the building blocks to the mixture. (C) 2011 Published by Elsevier Ltd.