2-(2'-furanyl)pyrrole | 63122-43-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-(2'-furanyl)pyrrole
• 英文别名: 2-(furan-2-yl)-1H-pyrrole；2-furan-2-yl-1H-pyrrole；2-(furan-2-yl)pyrrole；2-(2'-furyl)pyrrole；2-(2-furyl)pyrrole；2-furan-2-yl-pyrrole；Furan, 2-(2-pyrrolyl)-
• CAS: 63122-43-0
• 化学式: C₈H₇NO
• mdl: MFCD01649245
• 分子量: 133.15
• InChiKey: BYBZIJZNTITRID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2'-furanyl)pyrrole 在 盐酸 、 四丁基氟化铵 、 potassium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.33h， 生成 2-<5-<1-(2H-pyrrol-2-ylidene)ethyl>-2-furanyl>-1H-pyrrole hydrochloride
  参考文献：
  名称：

  A Second Generation Synthesis of Roseophilin and Chromophore Analogues

  摘要：

  A concise, flexible, and high-yielding synthesis of the macrocyclic compound 4 is outlined which served as a key intermediate in a previous total synthesis of the antitumor active alkaloid roseophilin 1. The key steps of this approach consist of a Pd(0)-catalyzed reaction of vinyloxirane 6 with sulfone 7 and in a subsequent ring closing metathesis (RCM) reaction for the formation of the 13-membered ring catalyzed by the ruthenium carbene Cl-2(PCy3)(2)Ru=CHCH=CPh2 introduced by Grubbs. Moreover, nitrile ylide cycloaddition reactions are used for the preparation of roseophilin side chain mimics. Finally, the synthesis of various chromophore analogues of 1 is reported, including deschloro-desmethoxyroseophilin 12 which is the most elaborate derivative of this complex target reported so far.

  DOI：

  10.1021/jo982088t
• 作为产物：
  描述：

  1-乙烯基-2-(呋喃-2-基)吡咯 在 sodium tetrahydroborate 、 mercury(II) diacetate 作用下， 生成 2-(2'-furanyl)pyrrole
  参考文献：
  名称：

  Trofimov; Korostova; Shevchenko, Russian Journal of Organic Chemistry, 1996, vol. 32, # 6, p. 865 - 867

  摘要：

  DOI：

文献信息

• Expedient one-pot synthesis of pyrroles from ketones, hydroxylamine, and 1,2-dichloroethane
  作者：Boris A. Trofimov、Al'bina I. Mikhaleva、Andrei V. Ivanov、Viktoria S. Shcherbakova、Igor' A. Ushakov

  DOI：10.1016/j.tet.2014.11.031

  日期：2015.1

  2- and 2,3-Substituted pyrroles are readily synthesized in a one-pot procedure from ketones, hydroxylamine hydrochloride, and 1,2-dichloroethane in the KOH/DMSO system (120 °C, 2–4 h), the yields of pyrroles ranging 11–85%. Aliphatic, cycloaliphatic, aromatic, and heteroaromatic ketones tolerate the reaction conditions.

  在KOH / DMSO系统中（120°C，2-4 h），可通过酮，盐酸羟胺和1,2-二氯乙烷的一锅法轻松合成2-和2,3-取代的吡咯。吡咯含量为11–85％。脂族，脂环族，芳族和杂芳族酮可耐受反应条件。
• [EN] MACROCYCLIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS MACROCYCLIQUES ET UTILISATIONS DE CES COMPOSÉS
  申请人：TP THERAPEUTICS INC

  公开号：WO2019023417A1

  公开（公告）日：2019-01-31

  The present disclosure relates to certain macrocyclic compounds that inhibit SRC and MET, and/or CSF1R, pharmaceutical compositions containing such compounds, and methods of using such compounds to treat cancer.

  本公开涉及抑制SRC和MET，和/或CSF1R的特定大环化合物，含有这些化合物的药物组合物，以及使用这些化合物治疗癌症的方法。
• Pyrrole-Type compounds, compositions, and methods for treating cancer or viral diseases
  申请人：Gemin X Biotechnologies Inc.

  公开号：US20040014987A1

  公开（公告）日：2004-01-22

  The present invention relates to novel Pyrrole-Type compounds, compositions comprising Pyrrole-Type compounds, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering a composition comprising a Pyrrole-Type compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell. The present invention also relates to novel Pyrrole-Type compounds, compositions, and methods useful for treating or preventing a viral infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the replication and/or infectivity of a virus.

  本发明涉及新型吡咯烷类化合物，包含吡咯烷类化合物的组合物，以及用于治疗或预防癌症或肿瘤性疾病的方法，包括给予含有吡咯烷类化合物的组合物。本发明的化合物、组合物和方法还可用于抑制癌细胞或肿瘤细胞的生长。本发明还涉及新型吡咯烷类化合物、组合物和用于治疗或预防病毒感染的方法。本发明的化合物、组合物和方法还可用于抑制病毒的复制和/或传染性。
• Silylamines in organic synthesis: preparation and some reactions of N,C-dilithiosilylamines
  作者：Stephanie A. Burns、Robert J.P. Corriu、Vilam Huynh、Joël J.E. Moreau

  DOI：10.1016/s0022-328x(00)99805-x

  日期：1987.10

  The dimetallation of some olefinic and aromatic N-trimethylsilylamines has been examined. Treatment with a two molar proportion of n-butyllithium gives organodimetallic reagents, which react with trimethylchlorosilane to give N,N,C-tris(trimethylsilyl)amines in 45 to 65% yields. The dianonic reagent obtained from (trimethylsilyl)(allyl)amine reacts with benzoyl chloride, N,N-dimethylformamide, eth

  已经研究了一些烯烃和芳族N-三甲基甲硅烷基胺的双金属化。用二摩尔比例的正丁基锂处理得到有机二金属试剂，其与三甲基氯硅烷反应以45％至65％的产率得到N，N，C-三（三甲基甲硅烷基）胺。由（三甲基甲硅烷基）（烯丙基）胺获得的二元试剂与苯甲酰氯，N，N-二甲基甲酰胺，-2-呋喃甲酸乙酯和苯甲react反应，得到取代的吡咯和吡啶。
• [EN] MACROCYCLES FOR USE IN TREATING DISEASE<br/>[FR] MACROCYCLES DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT D'UNE MALADIE
  申请人：TURNING POINT THERAPEUTICS INC

  公开号：WO2020257165A1

  公开（公告）日：2020-12-24

  The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

  本公开涉及某些手性二芳基大环衍生物，包含它们的药物组合物，以及使用它们治疗癌症、疼痛、神经疾病、自身免疫疾病和炎症的方法。