3-(10H-phenothiazin-10-yl)propan-1-ol | 63397-92-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 3-(10H-phenothiazin-10-yl)propan-1-ol
• 英文别名: β-(10-Phenothiazyl)propanol；10-(3-hydroxypropyl)phenothiazine；3-phenothiazin-10-yl-propan-1-ol；10-<3-Hydroxy-propyl>-phenthiazin；3-phenothiazin-10-ylpropan-1-ol
• CAS: 63397-92-2
• 化学式: C₁₅H₁₅NOS
• mdl: MFCD12073837
• 分子量: 257.356
• InChiKey: LWGBAJWQEZJNLO-UHFFFAOYSA-N

物化性质

• 沸点：
  160 °C(Press: 0.01 Torr)
• 密度：
  1.236±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  48.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(10H-phenothiazin-10-yl)propan-1-ol 在 吡啶 、 三氯氧磷 作用下， 以 氯仿 为溶剂， 反应 3.5h， 以65.2%的产率得到[β-(10-Phenothiazyl)propoxy]phosphonic acid dichloride
  参考文献：
  名称：

  Ultrafast Electrochromic Windows Based on Redox-Chromophore Modified Nanostructured Semiconducting and Conducting Films

  摘要：

  Described is the construction of an ultrafast electrochromic window. One electrode of this window is based on a transparent nanostructured TiO2 (anatase) film (4.0 mum. thick) supported on conducting glass (F-doped tin oxide, 10 Ohm cm(-2), 0.5 mum thick) and modified by chemisorption of a monolayer of the redox chromophore bis(2-phosphonoethyl)-4,4'-bipyridinium dichloride. The other electrode is based on a transparent nanostructured SnO2 film (3.0 mum thick) supported on conducting glass (F-doped tin oxide, 10 Ohm cm-2, 0.5 mum thick) and modified by chemisorption of a monolayer of the redox chromophore [beta-(10-phenothiazyl)propoxy]phosphonic acid. The electrolyte used is LiClO4 (0.2 mol dm(-3)) in gamma -butyrolactone. The excellent performance of a 2.5 cm x 2.5 cm window over 10 000 electrochromic test cycles-switching times (coloring and bleaching) of less than 250 ms, coloration efficiency of 270 cm(2) C-1, steady-state currents (colored and bleached) of less than 6 muA cm(-2), and memory of greater than 600 s (time required for low end transmittance to increase by 5%)-suggest a practical technology.

  DOI：

  10.1021/jp001763b
• 作为产物：
  描述：

  β-(10-Phenothiazyl)propionic acid ethyl ester 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以88.4%的产率得到3-(10H-phenothiazin-10-yl)propan-1-ol
  参考文献：
  名称：

  吩噻嗪衍生物作为新型抗结核药物的合成与生物评价

  摘要：

  设计并合成了两个吩噻嗪衍生物系列。测试所有化合物对结核分枝杆菌H37RV的抗结核活性。与氯丙嗪的母体化合物相比，化合物6e显示出有希望的抗结核活性，而哺乳动物细胞的细胞毒性要小得多，化合物6e值得作为新的抗结核剂进行进一步的研究。

  DOI：

  10.1016/j.cclet.2015.03.027

文献信息

• Electrochromic compound
  申请人：NTERA limited

  公开号：US07358358B2

  公开（公告）日：2008-04-15

  A compound for use in electrochromic devices. The compound includes (1) β-(10-phenothiazyl)propoxy phosphonic acid; (2) β-(10-phenothiazyl)propyl-phosphonic acid; and (3) β-(10-phenothiazyl)propionate phosphonic acid.

  用于电致变色器件的化合物。 该化合物包括（1）β-(10-苯并噻吩基)丙氧基膦酸；（2）β-(10-苯并噻吩基)丙基膦酸；和（3）β-(10-苯并噻吩基)丙酸膦酸。
• Method for dyeing dry hair
  申请人：Novozymes A/S

  公开号：US20020007524A1

  公开（公告）日：2002-01-24

  The present invention relates to methods for dyeing keratinous fibers, without significantly damaging the hair. According to the method of the present invention the fibers are treated in a dry state by contacting said fibers with at least one oxidoreductase and at least one dye precursor. In this way it is possible to dye, e.g. human hair, in a simple and efficient manner.

  本发明涉及一种染色角蛋白纤维的方法，而不会显着损伤头发。根据本发明的方法，通过将纤维与至少一种氧化还原酶和至少一种染料前体接触，以干燥状态处理纤维。通过这种方式，可以简单高效地染色，例如人类头发。
• Modification of polysaccharides by means of a phenol oxidizing enzyme
  申请人：Novozymes A/S

  公开号：US20010055794A1

  公开（公告）日：2001-12-27

  The present invention deals with a process for oxidation of a hydroxy group of C 1 and/or C 2 and/or C 3 and/or C 4 and/or C 5 and/or C 6 of a sugar monomer of an oligo- or a polysaccharide comprising contacting, in an aqueous medium, the oligo- or the polysaccharide with a phenol oxidizing enzyme and an enhancing agent, whereby an oligo- or a polysaccharide with altered characteristics compared to the native oligo- or polysaccharide is created.

  本发明涉及一种氧化 C 1 和/或 C 2 和/或 C 3 和/或 C 4 和/或 C 5 和/或 C 6 低聚糖或多糖的糖单体，包括在水介质中将低聚糖或多糖与苯酚氧化酶和增强剂接触，从而产生特性与原生低聚糖或多糖相比有所改变的低聚糖或多糖。
• Antimicrobial peroxidase compositions
  申请人：Novozymes A/S

  公开号：US20020119136A1

  公开（公告）日：2002-08-29

  Enzymatic compositions comprising a Coprinus peroxidase, hydrogen, peroxide or a source of hydrogen peroxide, and an enhancing agent such as an electron donor, e.g., phenothiazine-10-propionic acid; 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate); acetosyringate; C 1-8 -alkylsyringate; or a water-soluble halide or thiocynate salt such as potassium iodide, have antimicrobial properties useful e.g., for inhibiting or killing microorganizms present in laundry, on human or animal skin, hair, mucous membranes, oral cavities, teeth, wounds, bruises, and on hard surfaces, and can be used as disinfectant, a preservative for cosmetics, and for cleaning, disinfecting or inhibiting microbial growth on process equipment used for e.g. water treatment, food processing, chemical or pharmaceutical processing, paper pulp processing, and water sanitation.

  酵素组合物，包括科普林纳斯过氧化物酶、过氧化氢或过氧化氢源，以及一种增强剂，如电子供体，例如吩噻嗪-10-丙酸；2,2′-偶氮双（3-乙基苯并噻唑啉-6-磺酸）；乙酰丁酸；C......；C......；C......。 1-8 -或水溶性卤化物或硫代氰酸盐，如碘化钾，具有抗菌特性，例如可用作消毒剂、化妆品防腐剂，以及用于水处理、食品加工、化学或制药加工、纸浆加工和水卫生等工艺设备的清洁、消毒或抑制微生物生长。
• The Preparation of Some Derivatives of β-(10-Phenothiazinyl)propionic Acid and β-(2-Chloro-10-phenothiazinyl)propionic Acid
  作者：ERIK F. GODEFROI、EUGENE L. WITTLE

  DOI：10.1021/jo01116a027

  日期：1956.10