3-(4-pyridinylmethylene)-1-phenyl-2H-indolin-2-one | 154479-62-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(4-pyridinylmethylene)-1-phenyl-2H-indolin-2-one
• 英文别名: (3E)-1-phenyl-3-(pyridin-4-ylmethylidene)indol-2-one
• CAS: 154479-62-6
• 化学式: C₂₀H₁₄N₂O
• 分子量: 298.344
• InChiKey: HMXDQCMVHFYIDF-NBVRZTHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-pyridinylmethylene)-1-phenyl-2H-indolin-2-one 在 sodium hydroxide 、 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 利诺吡啶
  参考文献：
  名称：

  A Large Scale Preparation of the Cognitive Enhancer Linopirdine

  摘要：

  Linopirdine is a pharmacologically potent drug which stimulates central nervous system neurotransmitter release. A facile process used to synthesize linopirdine on a commercial manufacturing scale consisting of seven chemical steps with only a single isolated intermediate is described.

  DOI：

  10.1080/00397919308011258
• 作为产物：
  描述：

  1,3-二氢-3-羟基-1-苯基-3-(吡啶基甲基)-2H-吲哚-2-酮 以 溶剂黄146 、 异丙醇 为溶剂， 反应 2.0h， 生成 3-(4-pyridinylmethylene)-1-phenyl-2H-indolin-2-one
  参考文献：
  名称：

  A Large Scale Preparation of the Cognitive Enhancer Linopirdine

  摘要：

  Linopirdine is a pharmacologically potent drug which stimulates central nervous system neurotransmitter release. A facile process used to synthesize linopirdine on a commercial manufacturing scale consisting of seven chemical steps with only a single isolated intermediate is described.

  DOI：

  10.1080/00397919308011258

文献信息

• A Large Scale Preparation of the Cognitive Enhancer Linopirdine
  作者：Walter M. Bryant、George F. Huhn、James H. Jensen、Michael E. Pierce、C. Stammbach

  DOI：10.1080/00397919308011258

  日期：1993.6

  Linopirdine is a pharmacologically potent drug which stimulates central nervous system neurotransmitter release. A facile process used to synthesize linopirdine on a commercial manufacturing scale consisting of seven chemical steps with only a single isolated intermediate is described.