2-[(3,4-dibromophenyl)methylene]hydrazine carboximidamide hydrochloride | 849335-02-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(3,4-dibromophenyl)methylene]hydrazine carboximidamide hydrochloride
• 英文别名: 2-[(3,4-dibromophenyl)methylene]hydrazinecarboximidamide hydrochloride；2-(3,4-dibromobenzylidene)hydrazinecarboximidamide hydrochloride；AC-263093；1-(3,4-Dibromobenzylideneamino)guanidine Hydrochloride；2-[(3,4-dibromophenyl)methylideneamino]guanidine;hydrochloride
• CAS: 849335-02-0
• 化学式: C₈H₈Br₂N₄*ClH
• 分子量: 356.447
• InChiKey: JBDICMYLSPJKNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.24
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  76.8
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,4-二溴苯甲醛 、 肼甲酰亚胺酰胺一氯化氢 以to give the title compound (3093) as a white powder (655 mg, 92%)的产率得到2-[(3,4-dibromophenyl)methylene]hydrazine carboximidamide hydrochloride
  参考文献：
  名称：

  Treating neuropathic pain with neuropeptide FF receptor 2 agonists

  摘要：

  以下所描述的发明涉及到发现了介导急性痛觉和慢性神经病理性疼痛的神经肽FF受体亚型、与该受体亚型有选择性相互作用的化合物以及治疗急性疼痛和慢性神经病理性疼痛的方法。

  公开号：

  US20050136444A1

文献信息

• Discovery of Selective Nonpeptidergic Neuropeptide FF2 Receptor Agonists
  作者：Gilles Gaubert、Fabio Bertozzi、Nicholas M. Kelly、Jan Pawlas、Audra L. Scully、Norman R. Nash、Luis R. Gardell、Jelveh Lameh、Roger Olsson

  DOI：10.1021/jm9011998

  日期：2009.11.12

  We report the discovery and initial characterization of a novel class of selective NPFF2 agonists. HTS screening using R-SAT, a whole cell based functional assay, identified a class of aryliminoguanidines as NPFF1 and NPFF2 ligands. Subsequent optimization led to molecules exhibiting selective NPFF2 agonistic activity. Systemic administration showed that selective NPFF2 agonists (1 and 3)are active in various pain models in vivo, whereas administration of it nonselective NPFF1 and NPFF2 agonist (9) increases sensitivity to noxious and non-noxious stimuli.
• Treating neuropathic pain with neuropeptide FF receptor 2 agonists
  申请人：Scully L. Audra

  公开号：US20050136444A1

  公开（公告）日：2005-06-23

  The invention described below relates to the discovery of the neuropeptide FF receptor subtype that mediates acute nociception and chronic neuropathic pain, compounds that selectively interact with this receptor subtype and methods for treating acute pain and chronic neuropathic pain.

  以下所描述的发明涉及到发现了介导急性痛觉和慢性神经病理性疼痛的神经肽FF受体亚型、与该受体亚型有选择性相互作用的化合物以及治疗急性疼痛和慢性神经病理性疼痛的方法。