glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycine | 18861-82-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycine
• 英文别名: Glycyl->glycyl->glycyl->glycyl->glycyl->glycyl->glycin；Hexaglycylglycin；Heptaglycin；H-Gly-Gly-Gly-Gly-Gly-Gly-Gly-OH；2-[[2-[[2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetic acid
• CAS: 18861-82-0
• 化学式: C₁₄H₂₃N₇O₈
• 分子量: 417.379
• InChiKey: OZJLPHDWZPCDDP-UHFFFAOYSA-N

物化性质

• 沸点：
  1184.5±65.0 °C(Predicted)
• 密度：
  1.421±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -6.2
• 重原子数：
  29
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  238
• 氢给体数：
  8
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycine 在 盐酸 、 sodium hydroxide 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Affinity electrophoresis in multisectional polyacrylamide slab gels is a useful and convenient technique for measuring binding constants of aryl sulfonamides to bovine carbonic anhydrase B

  摘要：

  This paper describes convenient preparations of heterogeneous multisectional polyacrylamide slab gels and the protocols that use these gels to measure protein-ligand binding constants [using bovine carbonic anhydrase B (CAB) as a model system]. Unlike procedures for affinity electrophoresis using tube gels, all binding information concerning protein-ligand interactions was encoded in a single multisectional gel: the procedure involving for measuring binding constants required no postelectrophoresis manipulation of gels. Use of these types of gels improves the accuracy of affinity gel electrophoresis (AGE) by providing reliable internal protein standards. Binding constants measured by AGE agree with those determined in homogeneous solution by spectrophotometric measurements. This technique has been used to investigate the influence of the length of the spacer separating the ligand and the polyacrylamide backbone on the binding constants. Dissociation constants obtained using the affinity gels approach the values measured in free solution, when the spacer is sufficiently long (greater-than-or-equal-to 18 angstrom); affinity ligands having short spacers give high apparent dissociation constants.

  DOI：

  10.1021/ac00058a004
• 作为产物：
  描述：

  N-chloroacetyl-glycyl=>glycyl=>glycyl=>glycine 在 氨 作用下， 生成 glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycyl=>glycine
  参考文献：
  名称：

  Abderhalden; Weil, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1920, vol. 109, p. 295

  摘要：

  DOI：

文献信息

• Mechanochemical Prebiotic Peptide Bond Formation**
  作者：Tomislav Stolar、Saša Grubešić、Nikola Cindro、Ernest Meštrović、Krunoslav Užarević、José G. Hernández

  DOI：10.1002/anie.202100806

  日期：2021.6

  still unclear as most oligomerization approaches rely on thermodynamically disfavored reactions in solution. Now, a combination of prebiotically plausible minerals and mechanochemical activation enables the oligomerization of glycine at ambient temperature in the absence of water. Raising the reaction temperature increases the degree of oligomerization concomitantly with the formation of a commonly

  益生元地球上存在的氨基酸，无论是源自内源性化学途径还是由陨石传递，都是公认的。由于大多数寡聚化方法依赖于溶液中的热力学不利反应，因此从灭活氨基酸到肽的益生元合理途径仍不清楚。现在，益生元似是而非的矿物质和机械化学活化的组合能够在无水的情况下在环境温度下进行甘氨酸寡聚化。升高反应温度会增加低聚度，同时形成通常不需要的环状甘氨酸二聚体 (DKP)。然而，DKP 是甘氨酸机械化学低聚中的生产中间体。
• Compositions and methods for the prevention or treatment of cancer and bone loss associated with cancer
  申请人：Amgen Inc.

  公开号：EP1800691A2

  公开（公告）日：2007-06-27

  The present invention relates to compositions and methods for the prevention and/or treatment of bone loss associated with cancer. More particularly, the invention relates to OPG compositions and methods for the prevention and/or treatment of bone loss comprising said compositions. The invention also relates to the use of OPG compositions for the treatment of multiple myeloma.

  本发明涉及预防和/或治疗与癌症相关的骨质流失的组合物和方法。更具体地说，本发明涉及 OPG 组合物和利用所述组合物预防和/或治疗骨质流失的方法。本发明还涉及使用 OPG 组合物治疗多发性骨髓瘤。
• Methods and compositions for the prevention and treatment of anemia
  申请人：Amgen Inc.

  公开号：EP1961425A2

  公开（公告）日：2008-08-27

  Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematrocrit and treat anemia. Also disclosed are new hyperglycosylated erythropoietin analogs, methods of production of the analogs, and compositions comprising the analogs.

  本发明公开了提高和维持哺乳动物血细胞比容的方法，包括施用红细胞生成素的高糖基化类似物。与等摩尔量的重组人促红细胞生成素相比，可减少类似物的给药次数，以获得可比的目标血细胞比容并治疗贫血。另外，也可以施用较低摩尔量的高糖基化类似物，以获得相当的目标血细胞比容和治疗贫血。还公开了新的高糖基化促红细胞生成素类似物、类似物的生产方法和包含类似物的组合物。
• Combinations for the treatment of cancer
  申请人：IGNYTA, INC.

  公开号：US10869864B2

  公开（公告）日：2020-12-22

  Described herein are combinations comprising a therapeutically effective amount of a first agent and a therapeutically effective amount of a second agent, wherein the first agent is an inhibitor of ALK, ROS1, TrkA, TrkB, or TrkC activity, or a combination thereof, and methods of using such combinations in the treatment of patients having cancer.

  本文描述了包含治疗有效量的第一种制剂和治疗有效量的第二种制剂的组合物，其中第一种制剂是ALK、ROS1、TrkA、TrkB或TrkC活性的抑制剂，或其组合，以及使用这种组合物治疗癌症患者的方法。
• Abderhalden; Neumann, Fermentforschung, 1933, vol. 13, p. 382,385, 392
  作者：Abderhalden、Neumann

  DOI：——

  日期：——