5-aminolevulinic acid p-toluenesulfonate salt | 865112-23-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-aminolevulinic acid p-toluenesulfonate salt
• 英文别名: 5-amino-4-oxopentanoic acid toluenesulfonate；5-aminolevulinic acid p-toluenesulfonate；Pentanoic acid, 5-amino-4-oxo-, 4-methylbenzenesulfonate；5-amino-4-oxopentanoic acid;4-methylbenzenesulfonic acid
• CAS: 865112-23-8
• 化学式: C₅H₉NO₃*C₇H₈O₃S
• 分子量: 303.336
• InChiKey: DMSRJJQJLOCKOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.62
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  143
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-氨基乙酰丙酸盐酸盐 、 对甲苯磺酸 在 氨 作用下， 以 水 为溶剂， 生成 5-aminolevulinic acid p-toluenesulfonate salt
  参考文献：
  名称：

  [EN] 5-AMINOLEVULINIC ACID SALT, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
  [FR] SEL D'ACIDE 5-AMINOLEVULINIQUE, MÉTHODE DE FABRICATION DUDIT PRODUIT ET UTILISATION DE CELUI-CI

  摘要：

  这是一段关于5-氨基乙酸盐在微生物、发酵、动物、医疗、植物等领域中的有用性，以及其制造方法、医疗用组成物和植物活力剂组成物的描述。

  公开号：

  WO2005100300A1

文献信息

• [EN] ACID ADDITION SALTS OF 5-AMINOLEVULINIC ACID OR ITS DERIVATIVES<br/>[FR] SELS D'ADDITION ACIDE D'ACIDE 5-AMINOLEVULINIQUE OU DE SES DERIVES
  申请人：PHOTOCURE ASA

  公开号：WO2005092838A1

  公开（公告）日：2005-10-06

  The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.

  本发明提供了一种5-氨基戊酸（5-ALA）或5-ALA衍生物（例如5-ALA酯）的酸加成盐，所述酸具有大约5或更低的pKa值，优选大约3或更低的pKa值，但该酸不包括盐酸。特别优选的盐是来源于选自磺酸及其衍生物，氢溴酸，硫酸，硝酸和磷酸组成的酸的盐。根据本发明的盐特别适用于用作诊断和光化疗治疗身体内外表面的疾病或异常的光敏剂。
• Acid Addition Salts Of-5-Aminolevulinic Acid Or Its Derivatives
  申请人：Braenden Jon Erik

  公开号：US20080064752A1

  公开（公告）日：2008-03-13

  The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.

  本发明提供了5-氨基戊酸（5-ALA）或5-ALA衍生物（例如5-ALA酯）与具有pKa约为5或更低的酸（优选约为3或更低），但该酸不是盐酸的酸加成盐。特别优选的盐是由选自磺酸及其衍生物、氢溴酸、硫酸、硝酸和磷酸的酸所衍生的盐。本发明的盐特别适用于作为诊断和光化学治疗身体内部或外部表面的疾病或异常的光敏剂。
• 5-Aminolevulinic Acid Salt, Process For Producing The Same And Use Thereof
  申请人：Tachiya Naohisa

  公开号：US20070203027A1

  公开（公告）日：2007-08-30

  A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.

  一种5-氨基乙酰丙酸盐，可用于微生物、发酵、动物、药物、植物等领域；一种生产该盐的过程；包含该盐的医用组合物；以及包含该盐的植物活化剂组合物。
• 5-aminolevulinic acid salt, process for producing the same and use thereof
  申请人：Cosmo Oil Co., Ltd

  公开号：US08173839B2

  公开（公告）日：2012-05-08

  A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.

  一种5-氨基乙酰丙酸盐，可用于微生物、发酵、动物、药品、植物等领域；一种生产该盐的方法；一种包含该盐的医药组合物；以及一种包含该盐的植物活化剂组合物。
• 5-AMINOLEVULINIC ACID SALT, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
  申请人：TACHIYA Naohisa

  公开号：US20120172227A1

  公开（公告）日：2012-07-05

  A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.

  一种5-氨基乙酰丙酸盐，在微生物、发酵、动物、药物、植物等领域中有用；一种生产其的方法；一种包含其的医药组合物；以及一种包含其的植物活化剂组合物。