benzamidomethyl 4-hydroxyphenyl ether | 247195-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzamidomethyl 4-hydroxyphenyl ether
• 英文别名: N-[(4-hydroxyphenoxy)methyl]benzamide
• CAS: 247195-17-1
• 化学式: C₁₄H₁₃NO₃
• 分子量: 243.262
• InChiKey: QQWGVAIRPLWXDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (benzamidomethyl)triethylammonium chloride 、 benzamidomethyl 4-hydroxyphenyl ether 在 TEA 作用下， 以 水 、 丙酮 为溶剂， 以82.39%的产率得到benzamidomethyl 4-(benzamidomethoxy)phenyl ether
  参考文献：
  名称：

  Simple Method for Benzamidomethylation of Phenols in Water Solution

  摘要：

  Benzamidomethyl ethers ROCH(2)NHBz (5) (R = aryl, cyclohexyl and benzyl) were obtained in high yields in reactions of ROH (4) with (benzamidomethyl)triethylammonium chloride 3 as a benzamidomethylation agent. Reactions occurred in water, except reactions of cyclohexyl and benzyl alcohol with 3 that occurred in CHCl3.

  DOI：

  10.1080/00397919908085975
• 作为产物：
  描述：

  N-氯甲基-苯甲酰胺 、 alkaline earth salt of/the/ methylsulfuric acid 在 TEA 作用下， 以 水 、 丙酮 为溶剂， 反应 0.5h， 生成 benzamidomethyl 4-hydroxyphenyl ether
  参考文献：
  名称：

  Simple Method for Benzamidomethylation of Phenols in Water Solution

  摘要：

  Benzamidomethyl ethers ROCH(2)NHBz (5) (R = aryl, cyclohexyl and benzyl) were obtained in high yields in reactions of ROH (4) with (benzamidomethyl)triethylammonium chloride 3 as a benzamidomethylation agent. Reactions occurred in water, except reactions of cyclohexyl and benzyl alcohol with 3 that occurred in CHCl3.

  DOI：

  10.1080/00397919908085975

文献信息

• Simple Method for Benzamidomethylation of Phenols in Water Solution
  作者：Emil Popovski、Ljiljana Klisarova、Dražen Vikič-Topić

  DOI：10.1080/00397919908085975

  日期：1999.10

  Benzamidomethyl ethers ROCH(2)NHBz (5) (R = aryl, cyclohexyl and benzyl) were obtained in high yields in reactions of ROH (4) with (benzamidomethyl)triethylammonium chloride 3 as a benzamidomethylation agent. Reactions occurred in water, except reactions of cyclohexyl and benzyl alcohol with 3 that occurred in CHCl3.